I discovered the part of Morgan Levine’s presentation on the technical reliability of Epigenetic clocks and it’s right here:
What I might add to that is that we don’t know the technical reliability of the publicly accessible Epi clocks. If the utmost variation (from the video) is 9 years then it does make issues a bit unusuable. Whether or not the statistical methodology she refers to can be utilized to scale back the variation or not I don’t know, however all we have now (as people) is the uncooked knowledge anyway.
The entire of the presentation is value /listening to.
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Once I did an epigenetic check, the consequence was off by 19 years! I doubt it was appropriate. 9 years off could be extremely dependable as compared.
The corporate did agree with me and has given me one other check without spending a dime. I’m awaiting the outcomes!
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The 9 12 months determine was, nonetheless, from the identical pattern.
I do know there are variations on biomarkers as at instances I ship a pattern to 2 labs (and intend doing a 3 lab check presumably this thursday). I wish to know the reliability of the knowledge I’ve and what stage of variation is noise.
Like a lot of this, there’s conflicting details about epigenetic clocks. I’ve used the excel sheet from Mike Lustgarten just a few instances with numerous blood checks 6 months aside and have calculated my “Morgan Levine age” getting variations as massive as 7 years with no modifications in weight-reduction plan and way of life through the 6 month interval. There have been pretty massive swings up and down seemingly with out trigger. I doubt my organic age modified considerably throughout these six month intervals. I learn Dr. Levine’s e book hoping to realize an understanding of how simply her chosen handful of blood markers would so precisely predict “organic age” and didn’t get this info. I do know Mike Lustgarten (and plenty of others) act as if this epigenetic clock is a exact measurement (as exact as say measuring your waist circumference) of organic age. I additionally know that Matt Kaeberlein believes that such clocks are unproven and basically present nothing of worth. In a podcast with Matt and Peter Atilla, Atilla appeared to agree with Matt. I’m within the center. I imagine they’re of a lot much less worth than many assume they’re, however, I imagine they’re of some worth.
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I imply, is it bulk rnaseq? Does it rely upon CHANGES IN CELL COMPOSITION that occur? WHAT is the cell kind composition of the cells used for epigenetic clocks?
Even mRNA vaccination reduces epigenetic age – this might merely be as a result of modifications in WHICH BLOOD CELLS ARE BEING PRODUCED
Additionally see Andrei tarkov papers on stochastic DNA methylation that’s usually averaged out in bulk rna seq vs single cell rnaseq
In case you submit the biomarkers earlier than and after I can take a look at explaining the reasoning. I’m, nonetheless, d.runk in the mean time so you’ll have to wait a bit
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They need to point out Age plus/minus X but when only one firm do that, folks will simply discover it unusual that there’s just one which do it, so folks will order a check in an different firm.
It seems that it lowers all trigger mortality in Hungary !
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