Extra Rapamycin Would possibly Not Be Higher – I upped my Rapamycin Dosage to 38ng mL on common for the previous 7-months
Trying again on my Rapamycin historical past. After dosing on 6mg Rapamycin/Sirolimus for one full 12 months, I made a decision to do a organic take a look at to see if I used to be getting any advantages internally. Primarily based on evaluations, TruMe gave the impression to be a very good one for DNA Methylation via a spit take a look at. My outcomes not solely impressed me, additionally however the CEO of the TruMe Firm with a 12.4 12 months distinction. Organic I used to be 51 years and chronological I used to be 63 years on the time. Explaining to the CEO I used to be taking Rapamycin and Metformin – she felt it was an correct evaluation of my organic age 51 years. Congratulations!
I finished the Metformin on account of on and off diarrhea spells and it making me gassy. I re-tested with TruMe 6-months later – partially to verify that the take a look at was correct the primary time. I used to be not too shocked to see I used to be now organic age of 52 years – chronolgical age was 64 years with a 12 12 months distinction. I had misplaced virtually a half 12 months so a little bit of acceleration, however felt fairly good.
It was throughout this time, based mostly on Mikhail Blagosklonny’s remark to go as excessive as doable with out unintended effects and different customers going for the next dose, that I began utilizing Rapamycin with Grapefruit Juice (GFJ) – I used to be hitting ranges of higher 30’s to 56 ng/mL and having 3-day bouts of diarrhea. I lastly was capable of get some consistency at 6mg Rapamycin and GFJ and hitting 36 ng/mL based mostly on my LabCorp checks. This was my dose regiment (6mg and GFJ) from late July through finish of November.
My third and most up-to-date TruMe take a look at got here again every week in the past and had me 54.2 years organic age to my 64.8 chronological years.
I had misplaced some floor. My organic age elevated virtually 2.5 years within the 6 months. So it will seem that the upper rapamycin dosing has induced me to lose among the anti-aging advantages I gained on a decrease dose. To be 64 chronological years with a 54 organic age is just not unhealthy, a 10-years distinction. However, it was higher once I was doing a decrease dose with an virtually 13 12 months’s distinction between the 2.
Listed below are my TruMe experiences so as from 1st 2nd and third – present.
However learn on – my accelerated getting old on the next dose of Rapamycin will get worse.
TruAge Check by TrueMe previous 3-tests.pdf (123.5 KB)
One other organic getting old take a look at being utilized by the PEARL Rapamycin Human Medical Trials is GlycanAge, so I made a decision to attempt it. This makes use of a blood pattern – extra thorough, extra correct and dearer. I did my first take a look at at age 64 years – I had been on rapamycin at 6mg-8mg solely doses for 1 12 months 8 months. My report got here again that I used to be 37-years organic age based mostly on my glycans and lack of irritation. A 27-year age distinction from my chronological age. As I said, feeling extra Rapamycin could be higher, after that take a look at I considerably upped my Rapamycin dose to 38 ng/ml to 56 ng/mL and took on a really lean/shredded physique look. Little or no physique fats anyplace. After 7-month of the upper Rapamycin dose I re-took the GlycanAge take a look at. I used to be a bit shocked and disillusioned to see I had misplaced 15-years biologically on the upper dosage since my first glycan take a look at. My newest GlycanAge take a look at has me at biologically 52 years and chronological age 64. A 12-year distinction and nothing to complain about. However, it had been a lot better 27-year distinction. I really feel like I received the lottery after which pissed it away. Very irritating. Listed below are my GlycanAge checks.
GlycanAge outcomes November 2022.pdf (92.2 KB)
After I considerably upped my rapamycin, on each my TruMe and GlycanAge checks I had aged quicker prior to now 6 months. My routine is fairly constant in meals, dietary supplements and train. Previously 7 months the one important change to my eating regimen/dietary supplements and train routine has been the numerous elevated Rapamycin dose weekly. Maybe I used to be taking my MTOR1 too low for too lengthy and my MTOR2 has been affected. I don’t know. However, at the least for me it seems extra Rapamycin is just not higher. I wish to attempt to regain again my higher organic age numbers.
I’m re-evaluating my increased dosage regiment and have determined to return to the 6mg dose once more with Acarbose – not Metformin – and no GFJ. I’ve by no means had a rapamycin break prior to now 2.5 years of use. I’ve used Rapamycin each week continuous. I’m pondering of doing a reset. Going off rapamycin for one month and slowly reintroduce it 2mg first week; 4 mg second week and choose 6mg at third week. Possibly take a month break from Rapamycin each 6-months is so as too. I’ll do that new protocol and retest with TruMe and GlycanAge in 7-months and see the place I’m. Hopefully, I’m ready reverse and likewise decelerate the getting old to my prior numbers.
I’m positively a rapamycin believer. My well being points resolved or improved with rapamycin embrace: eradicated choking points (dysphagia); eradicated arthritis; decreased varicose veins; enlarged open veins; thickening of pores and skin (crepe pores and skin gone); important improved reminiscence; elevated power and euphoria; improved gums; elevated muscle energy; diminished visceral and different fats from my physique.
The most effective we are able to do is preserve testing. Discover just a few baselines and take a look at any adjustments we make. I used to be anticipating to have at minimal stalled or gradual my age development with the upper Rapamycin dose.
Seeing an acceleration in getting old on two very totally different checks has me involved about taking increased doses of Rapamycin. In my case, it seems that extra Rapamycin is just not essentially higher. As Drs. Peter Attia & Matt Kaeberlein state, it’s in regards to the dose. Each are Rapamycin customers – neither one doses increased than 8mg and take breaks. On this web site – we guess, we attempt, we study and we share with one another.
