A diabetic taking solely Metformin is more healthy than a diabetic who wants metformin plus one other medicine as Metformin is the primary line of protection. When the diabetes illness progresses and the diabetic is in worse form, docs add extra medicine. If the docs add extra medicine because the sufferers well being deteriorates, they’re faraway from the metformin examine as they don’t need sufferers with polypharmacy.
It’s like doing a long life examine and eradicating individuals from the examine once they develop a illness like most cancers, CVD, diabetes, and many others … I assure the group that’s left will dwell very lengthy lives as you’ve gotten eliminated everybody who develops worse well being. It skews the outcomes if you do this. No surprise diabetics on metformin lived longer than non diabetics!
“A diabetic taking solely Metformin is more healthy than a diabetic who wants metformin plus one other medicine as Metformin is the primary line of protection.”
Sure, however a diabetic taking solely Sulphonylurea can be more healthy than a diabetic who wants Sulphonylurea plus one other medicine. The 2 teams had been handled identically.
Additionally the management group of non-diabetics excluded anybody who wanted to begin a brand new diabetic medicine. In order that they too had been handled identically
Your different huge assumption is that metformin was the only first drug within the therapy protocol and that Sulphonylurea was solely used for troublesome or extra extreme instances. Through the interval in query – metformin and Sulphonylurea had been each used as a primary line therapy. It’s solely just lately (primarily as a result of the outcomes for metformin are a lot better) that metformin is used as first line to the exclusion of Sulphonylurea
Sure, you might be right. I’ll agree that Metformin is a good drug for diabetics. It’s additionally nice for these taking Rapamycin.
I believe we’re in all probability fairly near agreeing on a lot of this. I completely settle for that there’s no arduous proof to take metformin for elevated lifespan. However…
Do you agree that diabetics given metformin who don’t go on to wish further diabetes medicine to manage their diabetes dwell longer than non-diabetics who don’t go on to wish further diabetics medicine?
During which case – I recommend it will comply with that both:
- metformin is including to longevity via some non-diabetes associated mechanism (wherein case why wouldn;t it work in non-diabetics?)
- metformin is including to longevity via some diabetes-related mechanism akin to decrease blood sugar or diabetes-induced-inflammation which improves their well being to such an extent they dwell longer than the the non-diabetics. (During which case it means that non-diabetics’ well being could possibly be improved by the same mechanism – particularly if they’re peri-diabetic)
There’s no magic to the extent at which diabetes is recognized. And for somebody with a excessive (however not clinically diabetes) HBa1C there’s a cheap however unproven case for low dose metformin as follows:
Right here’s a proposed pragmatic strategy: In case you are pre-diabetic and have say, gum illness oir another indicators of persistent irritation – then metformin is value a trial as a result of it’d alleviate your gum illness/persistent irritation and scale back your Hba1c.
The uncomfortable side effects from a brief private trial are very low and even when decreasing irritation and HBa1C doesn’t add to your lifespan it ought to enhance healthspan.
Is that one thing you could possibly agree with? I’m genuinely – not simply looking for an argument
I’ve been taking 1000 MG of Metformin. I’m asking my physician for permission to up it 1500 MG. My common glucose for the final 30 days has been 90 MG. 83% of the time I’m inside a 70-110 vary. 10% above 110.
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TAME isn’t purporting to check the drug with the best potential for longevity. Even Nir would admit that. It’s testing a drug that’s demonstrably safer within the eyes of the FDA. Whether it is profitable, then it’ll pave the best way for testing of different longevity medicine, together with rapamycin.
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Talking of Joe R, from the 22 min mark on this podcast, we have now David Sinclair speaking about the entire Metformin and train factor….
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David Sinclair on Joe Rogan, sufficient mentioned.
I’m not a Joe Rogan fan, however loads longevity individuals have been on his present. Peter Attia greater than as soon as.
The Sinclair and Rogan interview is the primary longevity podcast I watched. It was fascinating on the time. It’s a great watch for somebody simply stepping into longevity.
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He’s finished three of them with him now I believe
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