Thanks for the hyperlinks. I’ll undergo them tomorrow.
Please know, I’m very clear within the data we “don’t” have so my many questions simply go in and course of with all the remainder.
Might I ask what you’ve tried, your dose vary having performed with it “up and down”, and the place you at the moment are? Do you count on to remain at that dose for some time or as a result of we alter/develop, you would possibly amend with every check end result.
What’s highest dose you’ve recognized or heard about
somebody/anybody taking that continues to be useful? Weekly or each different week dosing? Ideas?
What check(s) will assist me keep on high of present dose advantages vs the reversal level I’m seeing right here?
I do know some individuals take med holidays and a few don’t. What’s your considering on it – and/or a great protocol?
My concern is I’ve by no means taken a excessive sufficient dose to cross the BBB with a purpose to achieve advantages. Even when 6 mg isn’t my candy spot, is it doing one thing? Ideas.
What different anti getting old product(s) appear to, or are more likely to, profit synergistically? I examine metformin (unsure of mg) and some others I’m not accustomed to.
Do they add advantages that Rapa alone doesn’t appear to offer? Grapefruit juice? New to me however sounds necessary. Is it necessary to take my dose w/gf juice?
Thanks. Thanks.
I like so as to add others experiences/data to my “mind rapa spot”. I think about all of it and imagine it helps me make higher private selections.
I’ve paused rapamycin use many occasions previously three years after which restart on the similar degree i ended at with no points. I sometimes don’t have any apparent uncomfortable side effects whether or not i dose at 6mg /week or 28mg each 10 days to 2 weeks.
However to be cautious if that is the primary time you’ve gotten paused wouldn’t be a foul factor. I initially when i paused i feel i took two weeks to ramp again as much as my regular degree. However i’ve no proof that that is really efficient.
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Is it necessary to pause?
Ideas on “day without work” at the moment?
Thanks.
Most individuals pause to permit their physique to clear up any uncomfortable side effects they’re experiencing reminiscent of rashes or canker sores. Then they begin once more and their physique often has a greater tolerance for Rapamycin going ahead. Good luck and welcome!
Really I’m dosing each 10 days so my trough can get right down to zero from the 12 ng/mL. dose 2mg x 6 because of GFJ taken with it. I constantly get a multiplication of 6 from one 5 fluid ounces of recent Crimson Grapefruit juice taken with tablet.
There are totally different opinions on the problem of deliberate pulsing (or holidays) from rapamycin. Most docs who prescribe rapamycin, from what I can inform, don’t inform individuals to take these rapamycin holidays.
Peter Attia used to do periodic holidays from rapamycin within the first yr or two he was utilizing rapamycin, however has since (I imagine) stopped doing them.
The overall principle proper now could be that extended, frequent (each day) dosing of rapamycin ultimately causes mTOR2 inhibition, and that this inhibition causes lots of the detrimental uncomfortable side effects – together with immune suppression: Proof that mTORC2 inhibition is detrimental, by Dudley Lamming
However most of us use weekly dosing – with the idea that we don’t affect mTOR2 a lot given the schedule.
Rapamycin inhibits mTOR1 instantly upon oral consumption, which gives (its believed) the longevity advantages.
The take away is if you wish to be extraordinarily cautious you would possibly wish to take rapamycin holidays – however that will additionally lower the profit (because you aren’t taking the rapamycin throughout that interval).
