Dosing of Metformin – Rapamycin Longevity Information

Gastrointestional unintended effects can subside should you give it a couple of weeks or so.

In my n of 1, I didn’t discover that to be true. Continued intestinal points with acarbose if I eat carbs, particularly fruit.

“Additionally, I’ve had an amazing success switching from Metformin to Acarbose. Metformin made me gassy and gave me diarrhea. “

I discover that mind-boggling. Nonetheless, I believe Acarbose has little of the gassy unintended effects for folks on a low-carb food plan. I haven’t had or recognized anybody who had gassy side-effects from metformin.

That’s humorous as a result of nearly everybody I’ve met on it – usually for diabetes have comparable issues – no less than initially. With the dangerous critiques on metformin and inhibiting skeletal muscle mitochondrial respiration and protein synthesis in older adults (62 ± 1 years). From article within the hyperlink above.

So, I’m kinda glad Metformin didn’t agree with me so I didn’t take it recurrently (was on it for 3 months a 12 months in the past and off – then single dose as soon as a month hardly definitely worth the effort).

Actually liking Acarbose… let’s see if after 6 months dosing it takes me again on my organic exams.

You possibly can at all times take each.
“Nonetheless, there’s rising proof that these medicine might have results past their motion on glucose metabolism. For instance, metformin use has been reported to cut back the danger for sure types of most cancers [12,13]. Metformin use has additionally been related to cognitive enchancment in sufferers with specific types of dementia [14]. Acarbose use is related to cardiovascular advantages in diabetic sufferers [15,16] and has been proven to be protecting in opposition to atherosclerosis and myocardial infact in laboratory animal fashions”
One cause to think about taking metformin vs acarbose is due to its superior ant-cancer properties.
“37 research comprising 1,535,636 members, had been chosen when it comes to intervention and knowledge of most cancers incidence or mortality. Amongst metformin customers in contrast with non-users”

“In our meta-analysis, a 78% and a 46% danger discount had been discovered for liver most cancers and pancreatic most cancers incidence respectively, adopted by colorectal most cancers (23%) and breast most cancers (6%)”
That could be a massive cohort.

https://www.tandfonline.com/doi/full/10.1080/20010001.2019.1657756

I believe each Metformin and Acarbose are nice medicine and both is synergistic with Rapamycin. Nonetheless, I’m not certain you must take each. I’m not certain what would occur to your blood sugar ranges and insulin resistance. Is anybody taking each Acarbkse and Metformin with Rapamycin? Any statistics?

N=1
I’m non-diabetic however have borderline excessive fasting glucose ranges. For most individuals, I believe you would need to simply scale back the dosages. I’ve experimented with acarbose 300 mg in divided doses together with 100 mg of metformin morning and evening and it didn’t trigger my blood glucose to drop beneath 81 mm/dL. I finished acarbose due to extreme gassiness however I believe I would attempt to slowly ramp up over time to see if my system will ever alter to it.

Acarbose plus metformin fixed-dose mixture outperforms acarbose monotherapy for kind 2 diabetes – ScienceDirect

That’s the kind of examine I used to be on the lookout for. So it seems that acarbose + metformin + rapamycin may fit out optimally with the suitable dosage of every. Now, if we are able to discover out what that’s…

There are a number of particular person research that reported elevated danger for impaired cognitive efficiency, dementia, Alzheimer’s illness individually with metformin. Might be Vitamin B12 or might be one thing else.

You must truly perceive and skim the research otherwise you’ll miss lots of obtrusive points. The most cancers discount affiliation in diabetics might be no less than partially defined by evaluating metformin vs on insulin/sulfonylureas/no remedy – all of those choices are recognized to extend the danger of most cancers and might not be relevant to wholesome people.

But when the proposed mechanism is in reality true for wholesome people – rapamycin+acarbose shares all of those self same mechanisms/discount of IR with far fewer potential drug-drug interactions and also you don’t want to fret about Vitamin B12 standing, train interferences and so forth. Not solely that, it truly works within the ITP higher and there are fewer uncertainties concerning dosing.

I really like reside longer world. If Brad Stanfield may do what she does (ask clever questions and let the consultants converse), I in all probability wouldn’t canine on him a lot. Ideally, he would lose the pompous of affectations additionally …

I do take metformin and acarbose. However ageless RX is so stingy with the latter. They’ll solely promote me 16 of 25 MG drugs monthly.

Critically? My GP known as the pharmacy.
I’m on Acarbose 3 drugs 50 mg per day …take a capsule while you eat… 90 rely monthly. Price $10.

My physique has no adverse reactions to the three per day dose… no gasoline… no diarrhea… abdomen feels superb.

I haven’t seen my GP since I began all of this insanity. I’m wanting ahead to the go to. He’s the old school form of physician that may spend 45 min – 1 hour with me on my bodily, despite the fact that he in all probability shouldn’t. I’m going to ask him if he’ll prescribe any of the medicine I’m presently taking. If I may get Metformin and Acarbose, that may be a win. I believe I’ll have zero probability on rapamycin, however no less than I’ve Dr. Inexperienced.

Hiya, simply discovered this group, nice useful resource of like-minded folks!

Does anybody have expertise / analysis with respect to taking metformin and berberine together with rapamycin and acarbose all collectively?

I’m an energetic, wholesome, non-diabetic 57 12 months trying to optimize heathspan and lifespan (no medical circumstances).

AgelessRx gives all these medicines to me however I’m questioning if there’s any analysis to information us on the mixture advantages of those medicines?

I’m contemplating stopping metformin whereas retaining berberine, acarbose and rapamycin if the metformin profit(s) aren’t clear.

Admire any suggestions…

Welcome!
Metformin 500 mg capsule (4 occasions a day) was laborious on my intestine system.

The 50 mg Acarbose with every meal previous month and a half… brief time in physique works a lot better for me. Intestine is nice.

Rapamycin 2.5 years superb.

Analysis on Acarbose and Rapamycin combo for all times extension glorious.

Acarbose will be the technique to go primarily based on the ITP knowledge.

Received it, I did verify and ensure the ITP outcomes.

Nonetheless questioning if there’s any synergistic advantage of taking metformin + acarbose + rapamycin mixture therapies.

The TAME examine is metformin alone I perceive so we might not have analysis to information us right here.

Thank-you each.