Describing a multi-function drug as soiled simply doesn’t make sense. Many nutritional vitamins and different dietary supplements are multi-function. Why name them soiled? Right here is one other instance of the “soiled” drug metformin’s multi-function:
“Rapamycin/metformin co-treatment normalizes insulin sensitivity and reduces issues of metabolic syndrome in sort 2 diabetic mice”
“Right here, we present that mixture therapy with metformin ameliorates destructive results of rapamycin whereas sustaining its advantages”
https://onlinelibrary.wiley.com/doi/full/10.1111/acel.13666
IMO: This is a vital article to learn absolutely for these taking rapamycin. It addresses the elevated lipids and elevated blood glucose ranges in some topics taking rapamycin.
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That could be a nice article. It’s too dangerous that many individuals don’t learn these articles absolutely.
Is there a point out of the correct dosage of Metformin per mg of Rapamycin?
He simply says that as a result of it has a number of results on the physique and pathways. Matt Ok would say the identical about fasting. One of many issues he likes about rapamycin is that it solely impacts MTor. I can see how that may enchantment to a scientist who has to fret about confounding components. I’m completely happy to take a “soiled” drug!
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The facility of combinatorial approaches in ageing.
exhibits how some medication can synergize with metformin to extend lifespan in C. elegans. Proof of idea for his spin out
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Newest argument towards metformin dosing for non diabetics. I are inclined to agree. Nevertheless since Rapamycin creates Rapamycin diabetes and primarily based on the ITP knowledge, I’ll nonetheless take metformin earlier than switching to acarbose after I run out of metformin.
