B/c male intercourse hormones simply SUCK and that i HATE having them
Sinclair posted a tweet displaying that male uncastrated sheep epigenetically age extra shortly.
All of the trans ppl I do know want bica to spiro (spiro may cause spiro our bodies)… Lots of them additionally know supply low-cost bica.
https://hrt.cafe/bicalutamide/
Additionally does estradiol itself suppress testosterone?
athways by which 17aE2 alters mTORC1 perform are unsure, although it’s noteworthy that most of the results of 17aE2 on male mice are absent when this agent is given to males that had been castrated at 3 months of age (Garratt et al., 2017), implying that testosterone or some associated hormone is required for efficient 17aE2 motion.
There’s additionally the research the place Korean eunuchs had an extremely excessive variety of centenarians.
The considered longevity via this technique crossed my thoughts for under a second although.
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Not even for a second…intercourse might be the rationale (or a minimum of one of many causes) many individuals need elevated wholesome longevity 
However sure, most likely efficient for longevity:
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Yeah however some folks can’t get any intercourse, or it’s fully unimportant for them (for me, male intercourse hormones/organs have brought on nothing however pure pure distress). Fortunately it’s not crucial factor bc I don’t appear to be a person, however god I simply wish to be castrated (and I’ve ALWAYS needed to be castrated). The purple tape is simply an excessive amount of for me.
Additionally some simply wish to be accountable for their intercourse drive (one requested me for bica b/c he didn’t wish to have a excessive intercourse drive on a regular basis)
Why Dutasteride over bica?
Retains your prostate wholesome, helps you retain your hair in your head, and lowers intercourse drive…
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However the ITP means that males reply higher to many interventions…
@AlexKChen you have got traditionally ducked this query however what are you doing for resistance and cardio vascular train? Is your BMI under the wholesome vary? Imo, having a sustainable and efficient coaching program ought to supersede any food regimen or drug.
@AlexKChen a brand new paper you could discover attention-grabbing.
Whereas not one thing i might ever take into account, there appears to be a case to be made for males to get “mounted”, whereas youthful after which reverse the method when and if you wish to have youngsters? Although i don’t know if simply slicing the tubes would make any distinction… I ponder if there are surgical choices that may be reversed but in addition decrease getting older (wanting elimination of gonads)
Thanks for the reference – I’ll look into it
Jessica Hoffman has finished necessary analysis on this (see Spaying and neutering canines will help them stay longer – Information | UAB )
Austad and Hoffman say spayed and neutered pets stay longer, more healthy, happier lives as a result of they’ve fewer behavioral points and they’re much less prone to infections, degenerative illnesses, and traumatic/violent causes of loss of life. Spaying additionally protects feminine canines, spayed earlier than their first estrogen cycle, from mammary most cancers.
Oh positively, they’d positively eradicate the struggling and downside of IRL /incels. I most likely misplaced 3-4 complete years to “woman points” alone – “woman points” consists of being in relationships one shouldn’t have ever been by which then makes the time wastage a MUCH MORE relatable downside
(my drive is now so low that I’m fortunately virtually assured to be over them). I’m strongly in favor of elevated eunuchdom.
Extra on eunuchs – https://www.reddit.com/r/AskHistorians/feedback/5ocwv1/in_chinese_literature_it_often_seems_that_eunuchs/
The Weblog Remark That Achieved an Web Miracle – The Atlantic is super-important too. Not everyone seems to be privileged sufficient to have the ability to appeal to a feminine mate. I do know people who find themselves bitter at not having one. All the course of is extremely socially wasteful, and it’s simply higher for the world for there to be castrated (and un-bitter/un-ravenous!) individuals who focuses fully on science/the Web.
There are very very only a few trigger areas I’m keen to donate to (given my restricted funds) – selling voluntary human castration is one among these few areas.
[if only getting castrated in Thailand was easier…]
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Ladies stay longer and we aren’t positive of the entire the explanation why. Osterine and Lgd-4033 are a few molecules that might be helpful for males. They bind to the androgen receptor and assist to develop muscle, bone, and connective tissue. Additionally they trigger the pituitary to decrease luteinizing hormone, testosterone, and intercourse hormone binding globulin. Bodybuilders use/abuse these chemical substances to develop muscle, however in addition they flip off the testes. Castrated males typically undergo from osteoporosis, however lgd-4033 prevents osteoporosis. I’d be involved about coronary heart illness with long run use of those analysis chemical substances. Some testosterone aromatizes into estrogen in a wholesome male and this appears to guard the center. Eunuchs wouldn’t have extra coronary heart illness than common so far as I do know. Does the adrenal cortex regulate estrogen in a castrated male? There are not any long run research of lgd-4033 for the aim of chemical castration in people or animals, nevertheless it looks like a very good candidate. We do know that lgd-4033 halts benign prostate hyperplasia, and should forestall or deal with prostate most cancers… As with so many molecules we’d like good research.
Right here is a few data on castrated canines. They’ve much more hip issues: Golden retriever research suggests neutering impacts canine well being.
Chemical castration appears preferable to elimination of the testes since it’s typically reversible to some extent.
