Lithium Supplementation – Rapamycin Longevity Information

FWIW

Evaluation the next;

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4100432/

I purchase mine from Life Extension for longevity. The serving dimension is 1000 mcg of lithium orotate each day.

I feel the serving is definitely 1000mcg of elemental lithium supplied as orotate.

It seems on the label this fashion: (as lithium orotate). So I see there’s a distinction. I simply didn’t find out about that.

The distinction is in how a lot of the Lithium ion there’s.

Lithium has an atomic weight of 6.941 Lithium Orotate has a molar weight of 162.03g. For this objective, due to this fact, to get a milligram of Lithium you want 162.03/6.941=23.34 milligrams of Lithium Orotate.

Labelling will not be at all times that clear, however you might be in all probability taking 23.34 milligrams (give or take just a few milligrams) in every capsule.

7UP used to include lithium. It was referred to as “lithiated lemon soda”.

In 1949 the Australian psychiatrist John Cade printed research that confirmed that lithium may very well be used to deal with manias and stabilise bipolar issues. [Med J Aust. 1949 Sep 3;2(10):349-52.] Cade wanted a lot increased concentrations of lithium to do that than have been present in 7UP. However when Cade found that even increased concentrations have been poisonous, the producer of 7UP eliminated lithium from its product.

Lithium labored so properly, nonetheless, that Cade initially thought that bipolar issues have been attributable to a scarcity of lithium. This concept led to ‘nutri-criminological’ research which revealed that in areas the place the consuming water contained extra lithium there have been decrease critical crime charges and fewer suicides. [Biol Trace Elem Res. 1990 May;25(2):105-13.]

Inform the mayors of the cities under.

https://worldpopulationreview.com/us-city-rankings/most-violent-cities-in-america

The twenty cities with the very best violent crime charges (variety of incidents per 100,000 individuals) are:

1. St. Louis, MO (2,082)
2. Detroit, MI (2,057)
3. Baltimore, MD (2,027)
4. Memphis, TN (2,003)
5. Little Rock, AR (1,634)
6. Milwaukee, WI (1,597)
7. Rockford, IL (1,588)
8. Cleveland, OH (1,557)
9. Stockton, CA (1,415)
10. Albuquerque, NM (1,369)
11. Springfield, MO (1,339)
12. Indianapolis, IN (1,334)
13. Oakland, CA (1,299)
14. San Bernardino, CA (1,291)
15. Anchorage, AK (1,203)
16. Nashville, TN (1,138)
17. Lansing, MI (1,136)
18. New Orleans, LA (1,121)
19. Minneapolis, MN (1,101)
20. Chicago, IL (1,099)

Lithium is offered in lots of mineral waters all through the world and is extremely bioavailable.
One model bought within the U.S. would solely require you to drink 2 liters a day for 1 mg of bioavailable lithium. After all the opposite minerals may very well be problematic for some. Some German waters include virtually 2 mg/L

Detrimental in mice https://onlinelibrary.wiley.com/doi/full/10.1111/acel.13479

However mice die method an excessive amount of of most cancers, and lithium appears to behave on mechanisms independently of most cancers

I feel the info is pretty convincing that lithium supplementation is nice to your well being, cognition and lifespan. I take lithium orotate each evening.

Yep, I consider there was a case report within the literature involving damaging results from increased dose orotate complement type inflicting a hospitalization someplace if one needs to look into it. It seems to probably be near equal.

Frankly, I’m not even notably satisfied by the prompt results of epi proof for suicide prevention on microdosing lithium at 1-3 mg, however I’m not doubting a possible temper impact on even low doses round 5-15 mg.

My take is ~1 mg (spaced out in water from USP grade lithium carbonate IR, wished I had the advantage of ER model) is extremely, extremely unlikely to trigger vital long-term hurt if any, with a possible shaky profit based mostly on a poorly accomplished trial at a barely decrease microdose on AD (with some lack of key particulars within the trial) that additionally used lithium carbonate. Not notably satisfied but on it having sufficient empircial proof to considerably enhance healthspan or lifespan in people on the dose I’m taking if it even has any impact within the first place, however the mechanistic gamble on this occasion vs potential for hurt appears okay in my private scenario.

I ordered a 1mg lithium orotate complement so as to add to my stack that ought to arrive in the present day. @JuanDaw I’ve lived in one of many cities listed in your submit for the final 28 years so I believe my consumption has been low.

My submit above reveals cities with excessive crime charges per capita. The suggestion of including lithium to metropolis consuming water was in jest, as a result of there is no such thing as a displaying that these cities’ consuming water have low lithium content material. The connection is made based mostly on the untested speculation of Australian psychiatrist John Cade.

This concept led to ‘nutri-criminological’ research which revealed that in areas the place the consuming water contained extra lithium there have been decrease critical crime charges and fewer suicides. [Biol Trace Elem Res. 1990 May;25(2):105-13.]

My lithium orotate arrived yesterday, in time for my weekend dosing of kaempferol, myricetin, and lithium. I began kaempferol and myricetin the weekend previous. That is for my self-experimentation of substitute for rapamycin (or everolimus), and trametinib (a MEK inhibitor and anti-cancer), as posted under.