Aspect Results of Rapamycin (half 2)

Is it attainable so that you can get a blood sirolimus stage take a look at the place you reside? It might be actually fascinating to know what ranges you’re getting out of your mixture. Between the GFJ and EVOO you possibly can be getting from 3 to six X or greater the conventional ranges, so equal to as much as 24mg or extra. Everyone seems to be totally different… I’ve tried as excessive as 28mg equal (with GFJ and EVOO) with no noticeable unintended effects, however then I additionally received a mouth sore at round 6mg as soon as, and used to get rashes each dose once I wore my Fitbit (which I’ve now stopped sporting on account of this subject). Everyone seems to be totally different. It’s possible you’ll be discovering that this dose stage is just too excessive for you (should you don’t need the facet impact).

From what I’ve learn, rapamycin does penetrate the blood-brain barrier, and doubtless the upper you go the better the penetration (although I doubt its from the topically-applied head lotion).

Rashes are such a typical subject with rapamycin, that I think its principally the rapamycin that’s your subject.

Hmmm… positively would cease the hair tonic.

You possibly can preserve your blonde with simply DMSO, minoxidil, reveratrol and EGCG.

I by no means had any reactions… however there’s plenty of totally different meds interactions with that brew.

Cling in there.

To be trustworthy, the rash is simply an eyesore. I don’t wish to lose any well being advantages for a beauty subject. I used to be extra apprehensive in regards to the hand rash, however I wish to discover a answer to the neck one as properly. I’m making an attempt a number of lotions and lotions. Antibacterial ones appear to be working greatest.

As for a blood sirolimus take a look at, I’ll speak to my hospital once I get my subsequent well being check-up.

Additionally, since taking 4 mg + GFJ + EVOO, I’ve developed a longing for hamburgers. I usually should not have this. Is that this an indication that I’ll have affected my MTOR2 pathways since my physique is craving meat?

I assume something is feasible, however I actually haven’t seen this, however then I’m on a comparatively low carbohydrate weight loss plan. I don’t recall having seen this talked about right here or on different boards.

It might be due to the chilly climate or every other issue. I’ve simply had too many hamburgers this month!!! I’m usually a salad or sushi individual.

You actually are the king of anecdote.

Sorry, however my lab is unavailable proper now. When I’ve my group of medical doctors out there to do a full scientific evaluation, I’ll let you recognize. Possibly you’ll be able to share yours within the meantime.

Contemplating what number of tales listed below are anecdotal, together with the one on the entrance web page proper now…

Information isn’t exhausting to amass, all you want is an Oura ring and quarterly blood checks. Try Michael Lustgarten’s youtube channel as a mannequin.

However come on, “Rapamycin made me crave hamburgers…” ???

I used to be questioning if others had skilled the identical factor. If not, then it’s in all probability not the Rapamycin. I simply discovered it odd and out of character for me. The upper dosage is the one large change I’ve made just lately.

I admit, it’s kinda tacky in a cheeseburger type of means…

It looks as if many which can be experiencing sides are additionally utilizing grapefruit juice. Is there a risk that along with growing the blood ranges of rapa, it’s inflicting addition unintended effects in another method? The write up on my prescription particularly states GFJ will improve sides

They’ve executed research on this… they evaluated rapamycin (sirolimus) with GFJ as a result of it significantly will increase the bioavailability (by about 3.5 occasions on common, nevertheless it appears there is usually a very wide selection of responses – from 3X to 6X or greater).

The purpose of making an attempt this, was to truly cut back unintended effects for a given equal dosing… as a result of in Most cancers sufferers they have been testing as excessive as 90mg doses of rapamycin per day and that causes a number of unintended effects like diarrhea, GI points, and so forth.

The reply to your query about does GFJ improve unintended effects is type of sure and type of no. As a result of rapamycin will increase your “efficient dose” by 3 to six X what you take, it does improve the chance of unintended effects. However, should you evaluate the unintended effects (for instance), of taking 30mg dose of rapamycin by way of 30 tablets of 1mg sirolimus, to taking 10mg consisting of 10X1mg tablets of sirolimus with GFJ, then the unintended effects are typically decrease than in case you are taking the 30 tablets.

You possibly can learn all about it at these following hyperlinks:

Right here: Enhance Bioavailability of Rapamycin (2)

And the research right here: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4410974/

Glorious information, thanks

I’ve been doing it with GFJ and coping with cystic zits as a facet impact. I’ve executed a 2 week washout and I’m going to start out a better once-a-week dose with out GFJ to see if that makes a distinction

I’ve upped my dosage to five mg + GFJ + EVOO + metformin on a bi-weekly schedule. Surprisingly the unfavorable unintended effects are diminished. The rashes on my proper hand and neck have reappeared in the identical spots (precisely) however are a lot fainter than earlier than. No canker sores. The euphoric fatigue occurred the day after dosing and was rather more euphoric and fewer fatiguing. This doesn’t make sense to me until my physique is adapting higher to taking Rapamycin. The one main change is that I’ve added extra train into my way of life over the previous two weeks (each day squats) so this might be an element. Even have been getting plenty of sleep as I’ve been on trip for the previous 10 days and been sleeping in an additional 3 hours.

I began at 1 mg every week with citrus juice and doubled each week until I reached 6 mg with citrus juice.

I received a chilly sore on week 2 or 3, which is extremely uncommon for me — I solely received them once I was feeling and consuming and sleeping like utter crap throughout COVID and beneath a ton of stress. That’s latent herpes simplex virus so it’s clearly rearing its head as a result of immunosuppressant impact of rapa.

Additionally final week I received plenty of little pimples on my face. I’ve unusually clear pores and skin so something like that stands out. I handled them with a excessive frequency wand and so they’re gone.

A number of days in the past I additionally felt the slightest trace of a UTI — as a result of I’ve had them a lot previously I’ve a spidey sense for when one is across the nook. Went ballistic on cranberry extract drugs and it appears gone.

The very last thing is elevated resting coronary heart charge the month since I’ve began taking rapa.

This final one is the one factor that actually issues me because it in all probability signifies that I’m taking my subsequent dose earlier than all of the rapa has cleared my system. Haven’t executed any blood checks but to excellent my timing so I’ll attempt switching to biweekly schedule of the identical dosage which remains to be fairly excessive if taken with GJ.

Re: UTI: attempt D-Mannose as an alternative. It’s astonishingly efficient. I might now use d-Mannose over something once I really feel UTI approaching. I’ve discovered it more practical than even Rx antibiotics.