Low-frequency ultrasound seems to have rejuvenating results on animals – anti-aging

Bear in mind when Scientific American really did science? Bought Hewlett Packard calculators with RPN logic?

Now they’re speaking about cats and why they purr, they usually don’t even have a solution. This might have been written by any individual in elementary college, or Chat GPT.

However they purr at 100 Hertz and we’re on extra like 1,000,000. I do know it’s a joke, and never your fault, however SA actually went to shit.

Thanks for the article. By this logic, my semi tractor or for that matter all my farm tractors needs to be therapeutic machines. My tendons needs to be like metal.

Had prp on my shoulder final summer season and simply had it performed to my elbow too. It received worse all fall as I did my annual marathon for a pair months of harvest.

Cats are unknown creatures. I actually suppose they’re as prone to eat the man feeding them as they’re to attempt to heal him.

That’s superb, they will explode your tumor with out slicing you open.

My daughter has been working with a physician from MD Anderson, so I’ll see if she will discover out if it would work for her. Don’t wish to bore with particulars.

Ultrasound appears to me like an enormous deal, however frequency and depth and supply are vital and we aren’t getting the small print on this but.

Nice article.

one other writeup on this reseach:

Soaking in an ultrasonic tub tub/sizzling tub/ jacuzzi with adjustable frequency.

From the article: “Her father had suffered for years from important tremor, a motion dysfunction just like Parkinson’s.”

I used to be creating an “important tremor”, the “important” half I think about BS and may simply be addressed as age-related tremor.
In any case, I had been creating “important tremors”. My palms had grow to be shaky when attempting to eat. Like having the peas fall off the fork when attempting to get them into my mouth. Once I began rapamycin I used to be not anticipating that it could have any impact on this syndrome however after a couple of months of rapamycin, I grew to become conscious that my “important tremors” had disappeared.
I’m extraordinarily to listen to if anybody else has seen this end result from taking rapamycin, or am I only a one-off instance?

My uncle has it actually unhealthy and may barely eat. I seen a pair years in the past that it was coming. Extra like if I used to be shaking some salt or one thing my hand would hold shaking on it’s personal. The rapa made me neglect about it. I feel this can be a real factor.

Additionally I used to be getting the swallowing problem that Agetron had. My dad died of Bulbar ALS and I assumed that was what was taking place. This additionally went away.

It’s a tub, confirmed within the full paper.

Aged mice (21-24 months outdated) had been handled in a 4L glass beaker with an inside plastic cylinder of 13 cm peak and 15.2 cm in diameter. A plastic mess (mesh?) was positioned on high the cylinder that supported the mice and enabled them to relaxation with their 4 limbs and physique within the water. Degassed, 32-35°C water was poured into the beaker to a stage of 1 inch above the plastic mesh in order that half of the our bodies of the mice had been in water. As soon as the mice had been positioned within the water, intermittent ultrasound of low frequency and intermediate energy was utilized to the mice. The explanation for placing animals in water was that ultrasound was attenuated dramatically at air-water interfaces. Animals within the ultrasound teams had been handled at 72-96 h intervals for one month (10 therapies). In the course of the ultrasound remedy, we fastidiously noticed mouse exercise and their adaptation to the system. After remedy, the animals had been positioned in a separate cage with tissue paper to dry the animals after which they had been returned to their dwelling cage. Management mice had been positioned in the identical water tub for 30’ with out ultrasonication.

Period appears to be for half-hour per session. Once more, no point out of the ultrasound frequency. Authors are all from the College of Texas at Galveston. Hope any individual right here from the academe can attain out to them, and ask concerning the ultrasound frequency.

The tub could possibly be just like an ultrasonic cleaner, which produces about 43khz of sonification. The paper says:

As a result of ultrasound has been authorized for human publicity at energy ranges ten to hundred-fold greater than the degrees used on this research, we propose that it’s sensible to develop ultrasound-based therapies that might inhibit the rise within the fraction of senescent cells in tissues with getting older and thereby inhibit the onset of many age-related maladies.

So if it’s a hundredfold lower than the 1 to three mhz of economic ultrasound units, it could be within the vary of 10 to 30 khz. Some individuals have tried to supply DIY ultrasonic cleaners. I have a business gadget, for manufacturing of liposomal vitamin C.

I ponder if some rig will be hooked up to the bath, to supply the sonic waves.

I learn this as saying the ability stage is decrease, not the frequency.

“We report right here that low frequency ultrasound (LFU) rejuvenates senescent cells inflicting development…”

So if it’s a hundredfold lower than the 1 to three mhz of economic ultrasound units, it could be within the vary of 10 to 30 khz.

The quote above (I must spend a while studying how you can correctly do a quote since I couldn’t make it work) just isn’t the identical factor as what you quoted, I feel. Energy and frequency are totally different. Energy comes from the quantity management knob, frequency is the pitch, proper?

FYI – I’m undecided if there may be every other commentary on this new analysis by geroscientists – should you see it, please add to this thread:

My second quote comes from the second sentence, first paragraph, of the total paper.

Accumulation of senescent cells in tissue and organs results in getting older abnormalities. Rejuvenating senescent cells supplies a method to ameliorate getting older. We report right here that low frequency ultrasound (LFU) rejuvenates senescent cells inflicting development and lack of senescence markers. With fibroblasts and mesenchymal stem cells, LFU can allow elevated cell growth with out altering phenotype. At a subcellular stage, LFU causes mitochondrial fission and lack of lysosome staining that’s enhanced by rapamycin or Rho kinase inhibition and blocked by Sirtuin1 inhibition, in step with the speculation that LFU prompts autophagy. In vivo, older mice are rejuvenated by LFU as measured by elevated bodily efficiency and decreased ranges of senescent cells in kidney and pancreas measured by three markers. Thus, we propose that LFU alone will increase aged cell and complete animal efficiency.

The very time period repeatedly used LFU (low frequency ultrasound) signifies that it’s the frequency that’s low, not the ability. I concede that the primary quote refers to energy. However that will have been an inaccurate utilization. Between the various (instances LFU was used), versus the one, the error appears to be clear.