Whereas not precisely what the article is referencing, I can say anecdotally that it’s a lot simpler to maintain my vitamin D ranges above the 30ng/mL threshold (arguably one ought to shoot for increased, however that’s an affordable cutoff between low and regular) after shedding about ~40 lbs. When my weight was within the low 200s, even with 50k IU per week, my ranges had been simply barely about 30ng/mL in the summertime of 2021. Summer time of final yr I examined a bit increased, however with zero supplementation required.
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Excessive dose vitamin D will increase dying fee in randomized trial:
60 000 IU as soon as a month was used within the examine. Which might be 2000 IU a day (!).
I don’t have full entry to the paper. However I feel the blood ranges would most likely be related for each day dosing vs. as soon as a month for vitamin D.
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Ouch, been taking Vit D sparingly right here and there in excessive doses and now possibly i ought to simply cease. That dying enhance is HUGE, not simply important lol.
Vitamin D deficiency is horrible, however mega-dosing can be not good. It’s exhausting to inform how a lot to take and it actually will depend on the individual. This examine was completed on a principally aged Asian inhabitants which tends to be a lot skinnier/thinner and due to this fact extra affected by vitamin D3 supplementation as a consequence of low physique weight on common.
Pre-Diabetics ought to take 4,000 IU each day. 50% of the inhabitants has a vitamin D deficiency. Vitamin D3 is metabolized poorly in chubby people. 4,000 IU helps stop critical outcomes of COVID. 60,000 IU month-to-month results in the next danger of dying. In the event you spend a number of time within the solar, you want much less.
1,000 IU? 2,000 IU? 4,000 IU? 5,000 IU each day? I feel we will all agree that greater than 5,000 IU each day is a nasty thought and 1,000 IU is an effective minimal.
Truthfully, vitamin D is one customized/complicated complement the place one dimension doesn’t match all. I alternate between 1,000 IU and 5,000 IU. I feel I have to be within the 1,000-2,000 IU each day vary from right here on out as I’m poor.
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Me at 50K/week D3 and 120lbs:
It was within the 20-30 vary earlier than supplementation.
After which I see the Stanfield factor and apparently Kaiser is attempting to kill me.
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I did some n=1 experimentation with massive doses of cholecalciferol (d3) taking 24,000 and 12,000 doses. I discovered it disrupted my sleep for a day or three as my liver processed it into 25 hydroxy vitamin d (25ohd). I concluded that it was mildly poisonous as cholecalciferol. I take a upkeep dose of 3000 d3, however that’s inadequate to maintain me at excessive regular. When i wish to enhance my serum ranges i take 25ohd. I wish to preserve serum ranges alongside the highest finish of the conventional vary. I concluded i might metabolise 3000iu per day, however 6,000 was an excessive amount of. These figures might now have shifted, however i proceed to intention to maintain my serum ranges at excessive regular.
I feel I’m going to learn the total paper quickly, however I’m going to verify I get 1000 IU a day, which was extra handy than 2000 IU for me. I heard about 1000 IU from Brad, which was in response to endocrine society pointers.
Do you will have a supply for that? Final time I checked there was no good proof for covid/vitamin d.
If it’s a latest paper, appears no good:
I counsel studying;
By Tiago Henriques
For my part the e book is value studying/ buying{sure, I’ve bought a duplicate earlier a part of final yr]. That is the English translation from the unique, which is in Portuguese.
I do take very massive quantities of D³ 40,000IU plus{80,000IU highest dose I’ve taken] each day for a number of weeks/months at a time, then a break. And my blood ranges don’t go a lot above 50.
If I had a PDF copy accessible I’d put up.
Sure, there was a examine I linked to on this web site about how vitamin D3 prevented COVID. It was a examine completed on 400 healthcare hospital employees in Mexico. The findings had been important.
6.4% vs 24%
It wasn’t completed on 400, however 321, and greater than 30% dropped out throughout the examine. So it ended up being round 100 in every group, and we don’t know what occurred to the 50 in every group.
Additionally the randomization failed, with 6.2% having diabetes within the placebo group, however 1.9% within the vitamin d group. And 23% had been nurses within the placebo group, whereas it was 16.2% within the vitamin D group.
So it’s a weak examine.
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Its convincing sufficient for me when mixed with the opposite accessible info for me to attempt to beat my vitamin D deficiency.
