IGF-1 inhibitors and lifespan extension?

Is there any research on any drug that inhibit IGF-1 and which has proven good lifespan extension?

IGF1 receptor inhibition amplifies the consequences of most cancers medication by autophagy and immune-dependent mechanisms (2021)

“Right here, we report the identification of picropodophyllin (PPP), a cyclolignan alkaloid derived from the mayapple plant, as a potent inducer of autophagy that acts by means of the inhibition of insulin-like progress factor-1 receptor (IGF1R). When administered to tumor-bearing mice, PPP enhanced the
efficacy of immunogenic chemotherapy mixed with immunotherapy and these results relied on the induction of autophagy in malignant cells… PPP effectively blocked IGF1-induced IGF1R autophosphorylation, the activating phosphorylation of protein kinase B (finest often known as AKT), the phosphorylation of MTOR, and the exercise of MTOR advanced 1 (MTORC1), evaluated by assessing the phosphorylation of the MTORC1 substrates p70S6K and TFEB. Inhibition of IGF1R itself or that of the sign transduction cascade performing downstream of IGF1R (the PI3K/AKT/MTOR pathway) potently stimulates autophagy in addition to different stress-adaptive mechanisms. Certainly, an unlimited literature means that continual inhibition of this pathway by caloric restriction pharmacological inhibitors or loss-of-function mutations has the capability to increase the healthspan and lifespan in mannequin organisms and maybe in people as properly. PPP may very well be changed by one other IGF1R inhibitor, linsitinib, which has undergone analysis in scientific trials”

IGF-1R Inhibitor Ameliorates Neuroinflammation in an Alzheimer’s Illness Transgenic Mouse Mannequin (2020)

Medical setbacks cut back IGF-1 inhibitors to cocktail mixers (2012, current most cancers trial)
https://doi.org/10.1038/nbt1012-906c

“AMG-479’s failure will seemingly be a loss of life knell for the sphere of IGF-1 concentrating on. For the meantime,
although, it appears like trade can be taking a look at mechanisms apart from IGF-1R inhibition
in most cancers drug improvement”

Enclomiphene and clomiphene decrease IGF on the whole and when used as TRT. Apparently exogenous T doesn’t.

https://www.google.com/url?sa=t&rct=j&q=&esrc=s&supply=internet&cd=&cad=rja&uact=8&ved=2ahUKEwir_Mz5n779AhXZjokEHSpGDI8QFnoECAoQAQ&url=httpspercent3Apercent2Fpercent2Fwww.researchgate.netpercent2Fpublicationpercent2F270707189_Abstract_1326_Oral_enclomiphene_citrate_lowers_IGF-1_in_men_with_secondary_hypogonadism_while_raising_testosterone_Implications_for_cancer_prevention&usg=AOvVaw1yzs1wFFyVoHF5idfome0M