I discovered the part of Morgan Levine’s presentation on the technical reliability of Epigenetic clocks and it’s right here:
What I might add to that is that we don’t know the technical reliability of the publicly obtainable Epi clocks. If the utmost variation (from the video) is 9 years then it does make issues a bit unusuable. Whether or not the statistical technique she refers to can be utilized to scale back the variation or not I don’t know, however all we’ve got (as people) is the uncooked information anyway.
The entire of the presentation is value /listening to.
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Once I did an epigenetic check, the end result was off by 19 years! I doubt it was right. 9 years off can be extremely dependable compared.
The corporate did agree with me and has given me one other check at no cost. I’m awaiting the outcomes!
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The 9 12 months determine was, nevertheless, from the identical pattern.
I do know there are variations on biomarkers as at instances I ship a pattern to 2 labs (and intend doing a 3 lab check presumably this thursday). I wish to know the reliability of the data I’ve and what stage of variation is noise.
Like a lot of this, there may be conflicting details about epigenetic clocks. I’ve used the excel sheet from Mike Lustgarten a number of instances with numerous blood assessments 6 months aside and have calculated my “Morgan Levine age” getting variations as giant as 7 years with no adjustments in weight-reduction plan and way of life throughout the 6 month interval. There have been pretty giant swings up and down seemingly with out trigger. I doubt my organic age modified considerably throughout these six month intervals. I learn Dr. Levine’s ebook hoping to realize an understanding of how simply her chosen handful of blood markers would so precisely predict “organic age” and didn’t get this data. I do know Mike Lustgarten (and lots of others) act as if this epigenetic clock is a exact measurement (as exact as say measuring your waist circumference) of organic age. I additionally know that Matt Kaeberlein believes that such clocks are unproven and primarily present nothing of worth. In a podcast with Matt and Peter Atilla, Atilla appeared to agree with Matt. I’m within the center. I imagine they’re of a lot much less worth than many assume they’re, however, I imagine they’re of some worth.
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I imply, is it bulk rnaseq? Does it depend upon CHANGES IN CELL COMPOSITION that occur? WHAT is the cell sort composition of the cells used for epigenetic clocks?
Even mRNA vaccination reduces epigenetic age – this might merely be as a consequence of adjustments in WHICH BLOOD CELLS ARE BEING PRODUCED
Additionally see Andrei tarkov papers on stochastic DNA methylation that’s usually averaged out in bulk rna seq vs single cell rnaseq
For those who submit the biomarkers earlier than and after I can take a look at explaining the reasoning. I’m, nevertheless, d.runk in the meanwhile so you’ll have to wait a bit
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They need to point out Age plus/minus X but when only one firm do that, folks will simply discover it unusual that there’s just one which do it, so folks will order a check in an different firm.
It seems that it lowers all trigger mortality in Hungary !
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So as a way to promote longevity for our species, we must always push again baby bearing to later in life… Which is type of what society is already doing.
I believed I might add this hyperlink to this thread. It’s one other helpful factor even when written for advertising causes.
https://shoptrud.wpengine.com/silencing-the-noise-open-letter/
