Excessive IGF1 stage – Rapamycin Longevity Information

My blood stage IGF1 stage is excessive, regular vary is between 49 & 209 ng/ml
however mine is 293. i’m on rapamycin Zydus model for previous 3 months on 6mg per week dose.
my put up and pre therapy stage is identical on rapamycin dose.
how lengthy does it take IGF1 to come back down ?
am i able to do anything to carry my IGF1 to inside regular vary.
Endo confirmed i don’t have acromegaly utilizing GH stimulation take a look at

thanks

Hello Imran, thanks for posting. That’s attention-grabbing. When are you testing your IGF1 ranges, with respect to if you find yourself taking the rapamycin?

Rapamycin ought to possible decrease your IGF-1 ranges, at the very least in the course of the first few days after taking it.

What was your IGF-1 stage previous to taking rapamycin? Did you ever take a look at it?

My IGF-1 ranges is all the time been on excessive aspect monitoring for previous 3 yrs, i used to be not sure find out how to deal with it , so i needed to strive rapamycin with no profit thus far.

Earlier than Rapa IGF-1 Oct 2021 – 283 ng (6mg per week)
began rapamycin – 1st week of December 2021 – 21March 2022
After Rapa IGF-1 March twenty first 2022 – 293 ng

I’d take a look at the height sirolimus ranges after a dose to make sure you’re getting it into your bloodstream. See this for the LEF sirolimus take a look at:

Selenium supplementation inhibits IGF-1 signaling and confers methionine restriction-like healthspan advantages to mice | eLife In keeping with this text selenium supplementation lowers IGF-I ranges in rat fashions.

Can’t you could have excessive IGF1 ranges and low IGF1R ranges? The physique could compensate for discount in a single by growing the opposite

let me verify if blood take a look at is out there for IGF1R & Sirolimus take a look at in india and can add selenium to my complement stack
Thanks

You must verify your Selenium stage first – positive, too little impacts capacity to soak up vitamins, however an excessive amount of could be poisonous.
Selenium ranges are extremely variable throughout the entire inhabitants – you may discover you’re completely okay together with your stage.

good level will add selenium to blood take a look at listing

I’ve excessive regular testosterone but I don’t develop a ton of muscle in a short time or have any scientific signs that will recommend an excessive amount of or too little. Excessive-normal serum doesn’t essentially equal irregular.

Examine together with your endocrinologist.

FWIW, have you ever examined your insulin ranges? Excessive IGF1 could be related to diabetes/insulin resistance/metabolic problems. What’s your A1C? I used to have excessive IGF-1 and excessive irritation. What helped me was going low carb and intermittent fasting.

Right here is the impact on IGF1 and Sirolimus blood ranges with LEF blood assessments that I noticed from 15mg Rapamycin each different week:

1. Feb 17 (2 weeks after my final dose of Rapamycin and 12 hours quick) : IGF1 = 167 ng/ml, Sirolimus < 0.5 ng/ml. Fasting Insulin was 4.5uIU/ml, and A1C was 5.6. I’m Sort II diabetic, however take Metformin 2x500mg/day + Mounjaro 5mg/week.

2. Feb 20 (2 hours after 15mg Rapamycin & 12 hours quick, no GFJ or different dietary supplements recognized to enhance absorption of Rapamycin inside 24 hours) : IGF1 = 146 ng/ml, Sirolimus = 13.9 ng/ml

Others have reported peak Sirolimus blood ranges scaling roughly 1ng/ml per 1mg of Rapamycin with out GFJ or different absorption aids. In my case the Rapamycin is the Rapacan model ordered from India from dropshipmd.com.

I’m not positive what the everyday drop in IGF1 is meant to be or if the impact on IGF1 is most when Sirolimus blood stage peaks (usually 1-2 hours after consumption) or takes extra time to completely kick in.

Marvel if additional discount of A1C will assist decrease IGF1. Metformin has proven to cut back IGF1 and you’ve got room to the higher restrict of two,000mg. Can’t inform your physique fats proportion, however there appears to be a correlation. Lengthy water fasting and Keto helped me drop preliminary weight. 2,000mg of metformin helped me drop the ultimate kilos (I’m prediabetic). Sorry, however I’ve not repeated my IGF1 take a look at for over 5 years.

I’m talking off the cuff right here with out doing any analysis, however doesn’t IGF-1 activate/improve Mtor, not the opposite method round? So reducing the downstream goal of IGF-1,MTOR, could not have any impact on decreasing IGf-1…. from my expertise male hormones improve IGF-I, ie testosterone and DHEA, GH will increase it drastically, and carbs improve it, with protein and meals additionally having a slight impact. I don’t really feel like having an all protein weight loss plan will increase it crazily like a few of these individuals say. I even have low IGF-I ranges myself naturally, like 70-ish, And taking 15-25 mg of the DHEA appears to lift it over 100… I personally don’t really feel nearly as good when my IGF-I is that low, it’s arduous to elucidate…

Clearly, having raised ranges isn’t good both. I don’t assume round 150 just like the individual above is horrible, from my recollection these research contain a stage over 200, possibly even 300…

Sorry, didn’t imply to hijack this thread : I’m not the one with the excessive IGF-1 of 293, I simply posted my numbers after taking Rapa, to indicate that it does have a small quick decreasing impact.

I just lately discovered that the the Labcorp IGF1 blood take a look at could be inaccurate if supplementing with Biotin (Vitamin B7), which is current in most multivitamins and Vitamin B formulations : These must be discontinued 72 hours earlier than blood draw to get an correct IGF1 worth. I noticed this warning at marekdiagnostics.com, the positioning advisable in one other thread for the bottom price $59 (Labcorp) blood take a look at for Sirolimus. This additionally impacts most Labcorp hormone assessments (eg T3,T4, Testosterone, Estradiol, FSH, LH, SHBG) aside from the dearer excessive sensitivity variations primarily based on LC-MS know-how.