As somebody right here likes to say…
It’s like discovering a black cat in a darkish room.
Nevertheless when you’ve got a believable idea…
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Its all about perceived danger/reward calculations – largely primarily based off the information from the unique Mannick examine described above: What’s the Rapamycin Dose / Dosage for Anti-Getting old or Longevity? – #8 by RapAdmin
We actually don’t have any new knowledge (thats derived from medical trials). While you learn this whole thread you just about have the most effective data we’ve bought proper now. Its extremely imperfect. Individuals are attempting differing issues, watching their blood work to determine if issues are going the mistaken course, and persons are monitoring the unwanted side effects they discover (pores and skin rashes, and many others. that pop up sometimes) and making their choices (with their medical doctors) as to the most effective plan of action.
We’ve extra folks on the discussion board now, however we actually don’t have any new and good knowledge that may assist us information us on dosing optimization but.
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I moved to tri-weekly dosing.
My first purpose is {that a} 3 week interval ought to wash out the rapamycin between doses, (which doesnt occur with a bi-weekly schedule), so no want for the occasional rapa trip.
Second, my senolytic interval can be tri-weekly, taken towards the tip of the rapa cycle. Since I take curcumin every day apart from these occasions after I dont need to induce CYP3a4 (and intrude with rapamycin and dasatinib dosage) the tri weekly schedule ends in fewer days I have to keep away from curcumin.
Curcurmin is a extremely fascinating molecule. It’s also a HAT (Histone Acetyl Transferase) inhibitor and a HDAC (Histone DeAcetylase) inhibitor (in that it inhibits each opening up genes to transcribe them and shutting them down afterwards). Precisely what the affect of that is I don’t know. Quercetin oddly sufficient can be a each (HAT/HDAC) inhibitor.
It (C) additionally metabolises into Ferulic Acid and Vanillin (no less than in a minor means).
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Imo it’s the most effective schedule as a result of it permits to scrub it out utterly. I switched to 2.5 weeks. Thus far so good: blood markers are excellent, no adverse unwanted side effects, sleep is nice, power is nice too, and as well as gained some very needed kilos 
(from 107lb to 112 inside 3 months).
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Though I’m with you on this I feel one difficulty is the affect on WBC (a lot that in idea a low WBC is an efficient factor – and I’ve that in spades). WBC has a delayed affect due to the common lifespan of White Blood Cells. Therefore it’s not simply getting a discount in Rapa that issues, but additionally the knock on results.
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