Rapamycin and danger of heart problems – rapamycin

The skunk works model offers you >3X the mg for < 1/5 the price
(GoodRx < $20 for 30 50mg tablets), However my query was whether or not there can be any distinction in efficacy v. the compounded pharm. model.

The bempedoic acid research is supportive of the LDL’s causal function in ASCVD. Granted the consequences had been modest (13% relative danger discount, I consider?) however LDL discount was pretty modest as effectively (21% ?) and naturally we’d count on to see bigger danger discount with prolonged durations of time, as with all lipoprotein interventions. Observe this doesn’t imply that irritation isn’t critically necessary, simply that IMO we needs to be attacking ASCVD from each angles.

I’ve up to date strongly to take issues with a grain of salt from anybody who speaks about irritation. Why? The identical folks by no means point out confirmed causal danger components. It’s changing into a quack time period and all remedy panacea at this level, IMO. However I’m not going to be ideological about it. If there’s a drug that lowers irritation and that reduces CVD occasions, and so on, impartial of decreasing LDL, I consider it.

Some postulate that decreasing irritation develop into solely of curiosity at low LDL’s.

In observe, due to this fact, though not but proof based mostly, earlier than contemplating the addition of an anti-inflammatory drug, LDL-C could be lowered to a stage beneath 55 mg/dL (1.42 mmol/L), the brand new goal for very high-risk sufferers within the ESC tips

Did you learn the opinion paper (“false dichotomy”) that you just referenced? It helps precisely what I stated above. It even contains trials with two anti-inflammatory medicine that additional lowered danger above and past decreasing LDL. It’s true – it’s a false dichotomy. It’s not both/or, it’s each.

Sure, I wrote that earlier than I learn it.
My level was about ideology and folks both approach, not whether or not anti-inflammatory medicine work or don’t work for this goal.

I have to learn extra about anti-inflammatory medicine and ASCVD, however it looks like a good suggestion in case you’re stopping ASCVD by decreasing LDL as if anti-inflammation didn’t matter on the similar time.

Has anybody else observed that their blood coagulates faster through small cuts/wounds? If that’s the case, are you anxious about hypercoagulation in any respect?

I believe one of the vital noticeable side-effects or perhaps advantages has been how briskly I cease bleeding once I get small cuts or wounds since starting rapamycin.

I get my blood examined once more subsequent month, however is that this a worrisome signal? Is my blood too thick growing my danger for blood clots?

Attention-grabbing. I’ve not seen that anyplace as a aspect impact of rapamycin. My private expertise is kind of the alternative. Since I began rapamycin the blood circulation from a finger prick when I’m testing my glucose ranges is way bigger.

Are you positive you might be correctly hydrated?
Additionally, I’d recheck the dietary supplements or drugs you’re taking. I believe it’s in all probability one thing aside from rapamycin.

I’m not a giant dietary supplements man and am probably not taking the rest apart from a every day multivitamin. I keep effectively hydrated, I don’t drink soda. I common over 30 miles every week operating, which scientifically talking, train is a blood thinner.
Clearly that is n=1, however I solely had one life-style change when this began to happen, which was legit solely about 2-3 weeks after I began rapamycin and has been like this ever since. At first I believed it was superior, as a result of I appeared to even be therapeutic sooner (which continues to be the case).
However, a pal instructed me that it may very well be a unfavorable signal, how briskly my blood was coagulating after a small lower. After studying a bit into it, I’m a little bit anxious.
All my blood checks have been the identical put up rapa, barely elevated ranges of ldl cholesterol (which I had earlier than rapa as effectively).
It’s been 3 months since I final had them checked, and simply scheduled one other spherical of blood panels.

I assume, one factor I’m questioning, at what level ought to this be a factor to truly fear about? Might it’s fully regular and even wholesome? How a lot does quick blood coagulation correlate with the next danger of blood clots?

I’m not discovering solutions to those simply anyplace. Does anybody have any expertise or ideas?

I usually see in these boards folks saying, “I believe it’s one thing aside from the rapamycin.” When individuals are sharing their very clear and apparent expertise. I’m telling you, that is by far the obvious earlier than and after impact I’ve had. Nothing else is even shut. I do quite a lot of DIY and residential rework. I get quite a lot of nicks/cuts. That is clear and apparent.

Possibly its time to see in case your PCP desires to refer you to a hemotologist for doable clotting dysfunction. I’ve by no means heard of this as a aspect impact both. There are meals that may additionally contribute to lowered clotting time.

Did somebody prescribe this to you? You need to converse with them about what you might be experiencing

Simply curious, which meals might contribute to lowered clotting time? I haven’t modified my eating regimen a lot that I can consider. However, I haven’t dominated out the truth that rapamycin could be having an impact with one thing that was pre present in my every day/weekly eating regimen.

As an example. One factor I observed instantly is that an excessive amount of alcohol inside the first couple days of dosage doesn’t hit me actual effectively, so I largely avoid it inside a pair days of dosing. I nonetheless drink someplace between 4-10 items of alcohol every week.

Simple to google. Wholesome stuff like collards and Kale, e.g.

I’ve not used rapamycin for very lengthy however I’ve additionally observed that small wounds appear to heal sooner.
However I’m bleeding quite a bit from small wounds, no change there. However then once more I take curcumin and which may hold my blood skinny.

Does Zetia have an effect on clotting?

Nattokinase helps in opposition to clotti g and cleans blood and so on removes outdated clot factors in addition to dmged tissue, i take advantage of it from time to time in greater chunks

The significance of irritation as a predictor of coronary occasions throughout all ranges of LDL ldl cholesterol was acknowledged way back to 2005 within the NEJM. Emphasis on protecting the CRP < 2.

C-Reactive Protein Ranges and Outcomes after Statin Remedy | NEJM

CRP is a vital marker of irritation as a predictor of coronary artery illness. Sadly it’s affected by virtually any irritation or trauma and never all the time a dependable marker.