How low is your ferritin degree? What was it earlier than rapa? Could also be it’s safer to take rapa with out GFJ or EVOO to maintain the regular degree?
All of it is dependent upon your physique dimension. Bigger people can safely take greater than smaller ones, IMHO. I’m twice the dimensions of a few of our smaller members, so it is smart that they shouldn’t take the identical dose as me. I’ve not encountered any critical negative effects but, and have gone as much as 6 mg with GFJ and EVOO. However everyone seems to be completely different. A couple of people have skilled ankle swelling, and that’s after I would again my dosage down. Or within the case of some other critical aspect impact. I don’t depend canker sores, rashes or diarrhea as critical, however that’s my very own private name.
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The plan to 5mg is what most individuals do. In case you haven’t already, I undoubtedly suggest you learn these threads:
Right here: Enhance Bioavailability of Rapamycin (2)
Right here: Rapamycin Interactions with Different Meals, Drinks, Dietary supplements and Medication
Ideally it’s best to work with a health care provider. They sometimes prescribe between 3mg to 6mg in a as soon as per week dose. Going above that and dangers begin to improve. Common blood testing is effective (e.g. each few months or so) to assist see what the influence in your physique is.
You’ll want to research this thread: Aspect Results of Rapamycin (half 2)
and look ahead to negative effects.
A excessive fats meal with rapamycin will increase bioavailability by about 30%.
Grape Fruit Juice can improve by 350% to 600% or increased… so you might be successfully getting the good thing about 3.5X to 6X or increased instances the dose of rapamycin you’re taking. The hazard right here is that for a lot of medicines (some statins, and so forth.) this could trigger an overdose scenario which might be very harmful and trigger critical harm to your liver. Actually learn up on this if you’re contemplating this. Its not really useful by any docs, due to this danger.
In case you go increased in dosing above 6 to 10mg in a given week, due to the lengthy half-life of rapamycin, you danger having a buildup of rapamycin in your blood and over time that may trigger mTORC2 inhibition and immune system supression. This will make your physique extra vulnerable to infections, and whereas most of those infections are treatable and delicate or reasonable in severity, you possibly can learn above of research in hospital / most cancers conditions the place individuals have gotten extreme infections and at the very least one demise has occured (see submit above).
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I don’t know what my ferritin ranges had been earlier than I began rapamycin. My ferritin ranges had been being checked by the Purple Cross earlier than my blood donations and had been within the regular vary however they didn’t give me a quantity. Roughly 3 months after beginning rapamycin my ferritin degree was 39ng/mL then over the following 6 months I gave blood twice. When it was final measured on Feb. 23 of this 12 months it had dropped to 6ng/mL.
That seems like one thing to have checked by a health care provider. It’d or may not have a reference to the rapa. A fast google suggests it is likely to be brought on by lack of RBC (presumably not in the event that they allowed you to provide blood) or lack of iron. In both case, that’s an enormous drop.
My ferritin ranges will not be checked typically. I’ve a file of ferritin in 2006 (pre-Rapa interval) and in 2022 (12 years on Rapa). Each are throughout the required vary: 2006 – it was 25, and final 12 months 53. Appears like Rapa didn’t have an effect on it.
My weekly ferritin ranges from various labs are fairly variable. I’m not positive how a lot one can depend on anyone ferritin worth.
It’s most likely dependable if it additionally goes hand in hand with regular Iron, TIBC, MCH, MCHC, platelets, and so forth.
These are the values I’ve, they begin with a 12 months’s distinction, then transfer to 4 weekly and most are about weekly aside (some are the identical pattern)
420 337 358 329 332 404 371 412 325 204.6 364 202 337 176.2 176.2 319 172.9 205 253 205 145 175 157.9 165.7 171.4 190.9 180.4 173.4 222 176.7 ng/ml 298 291 mgc/L 202.5 187.8 174.9 140.4 155.4 170.5 123.2 150 152.6 147.6 168.7 177 201 165 203 168 165
To me it appears to be like prefer it has come down as my metabolism has shifted., however it’s fairly variable.
When did you give blood final earlier than Feb.23 when your ferritin was 6? You determined it was the impact of rapamycin somewhat than donating blood, or probably mixture of each? How lengthy are you planning to remain off rapamycin? Why simply not taking a smaller dose?
Except you utilize the identical lab.
I take advantage of just a few labs. Typically the sequetial figures are from the identical lab.
