I simply took 2 14mg capsules and see an impact eventually (however want to attend a day to see how lengthy it lasts/whether it is price it). 1 14 mg capsule didn’t do something to scale back starvation.
Edit a number of hours later: it didn’t forestall me from gobbling down 2 pints of blueberries and one whole field of almonds (160*6 * 0.80 energy). I’ll see if it nonetheless prevents me from additional starvation cravings tho. Or needing to drink a whole field of almond milk and needing extra raspberries. Damnit, after a number of hours it doesn’t assist that a lot.
I’m nonetheless going to attempt extra semaglutide at some later day however I feel the oral simply gained’t work. My pal who has tried terepatride has had higher experiences.
I additionally don’t want semaglutide as a lot as different individuals, however I lose a lot psychological power/time to needing to eat that I simply need this psychological load over with for as soon as.
Alex – have you ever completed any blood exams and organic age calculations previously 12 months? Are you able to share them? Would like to see how issues are going for you on this space…
I’m having the identical experiences of starvation with the oral model. The injectable is more durable to acquire however I could give it a attempt
3mg on a regular basis, then I attempted 6 mg on a regular basis
Once I began Rapamycin in June 2022, I weighed 178lbs and had a Physique Fats of 18.3% (DEXA). I now weigh 187lbs which isn’t the path I hoped my weight would go. I simply ordered some Semaglutide and can begin a 0.25mg every week protocol. I could do one other DEXA scan earlier than beginning. I’m hoping for outcomes just like @AmyK and @Rapasailor. Are there any really helpful blood take a look at to watch for antagonistic results?
The one antagonistic impact is an elevated resting coronary heart fee. You actually need to eat protein and raise weights on Semaglutide. It’s catabolic to muscle. Additionally, don’t drink energy. Did you see: Lean mass loss on GLP-1 receptor agonists
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Studying by way of this attention-grabbing thread, I discover the accounts describing the usage of GLP-1a’s fairly correct. A lot of related factors relating to low/micro dosing, questions on long run use/want, availability. It has been a recreation changer for thus lots of my purchasers, however stays an evolving space. Attending to an optimum lean weight might be probably the most essential methods of bettering well being and stopping continual ailments.
I’m one of many few MD’s board licensed in weight problems/weight reduction drugs and truly skilled in the usage of these medicines. Our concierge observe is specialised on the intersection of Age-performance / Weight reduction / Most cancers prevention, and we work exterior of insurance coverage constraints to assist handle our purchasers to get the prescription, off-label and compounded medicines they want. We observe our purchasers intently to make sure security and efficacy with the assist of an professional medical workforce. At some point the normal medical group could catch on how essential that is, however for now we fill this massive un-met want for personalised age-performance and preventative care.
So, for these on the lookout for certified, skilled help and assist with coordination of medicines (NAD+, Rapamycin, Metformin, LDN, GLP-1a) and optimizing well being, we’re right here for you. Not trying an Advert right here, simply need of us to know that there are physicians like me keenly centered on aiding on this space.
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GLP-1 receptor agonists, on this case Ozempic are apparently efficient in opposition to alcohol additionally. It’s one thing Eades is passing alongside. I don’t truly drink in any respect so can’t assist him, however he’s received a query in there for many who do drink and in addition take GLP-1 agonists:
That explains Yacon syrup. Additionally perceive beans, greens and entire grains since they’ve soluble fiber, which turns into SCFA. I don’t perceive avocado,nuts or lean protein sources like eggs. I eat them, simply don’t perceive how they flip into SCFA.
I might assume jerusalem artichokes, inulin, Yacon in any kind and Acarbose would all do the trick.
The factor which may be anti-longevity is that
”Semaglutide additionally helps the pancreas produce insulin”
Suppose we wish elevated insulin sensitivity (good) and all else equal keep away from elevated insulin manufacturing (unhealthy) (exterior of ailments the place the pancreas doesn’t produce sufficient insulin)
Marvel if growing GLP-1 by way of meals has the identical influence on insulin?
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Btw the second a part of piece of the article is attention-grabbing
” Some research have proven GLP-1 ranges, significantly after meals, are decrease in individuals with weight problems. This may very well be from lowered manufacturing of GLP-1 or elevated breakdown. The receptors that detect it may also be much less delicate or there may be fewer receptors. This may very well be due to variations within the genes that code for GLP-1, the receptors or elements of the pathways that regulate manufacturing.”
Maybe that gives targets for CRISPR or subsequent gen gene modifying, that might assist us make calorie restriction straightforward…
Even when the article appears to assume that we can not modulate these genes for some cause:
”These genetic variations are issues we will’t change.”
