Lastly have my publish Rapa regime information (delayed like everybody by Tru-Diagnostic).
The protocol publish the preliminary testing was to regularly ramp up Sirolimus (used Zydus model) from 2mg per fortnight to the purpose the place I had an antagonistic response.
Dietary supplements being taken repeatedly at this level had been Vit D&Okay (identified as poor), Magnesium, Garlic Capsules and Ginger tablets (as instructed by my MD).
My philosophy has all the time been to attempt to get all the pieces from food regimen by the use of consuming as many alternative meals varieties as attainable every day (inside a 8-9 hour feeding window). After I know I’ve been poor in sure areas I’d complement as applicable (e.g. we had a interval when sardines had been briefly provide so I used to be supplementing fish oils and astaxanthin on the time). Different occasional dietary supplements could be a multi B vitamin, zinc if the children come house from faculty with colds (often and by no means caught a single one!) and copper if felt overdoing the zinc.
Half manner by means of this era, I began common consumption of Creatine and Tongkat Ali.
2 doses at 2mg, 2 doses at 4mg, 5 doses at 6mg, the latter two of which had been taken with EVOO (and EVOO was continued from this level (no GFJ used on this in any respect)).
Nothing was observed in any respect good or unhealthy at this dose.
Then went to 8mg at which level I did discover elevated focus/focus and stamina. That mentioned, it will take greater than 12 hours to take impact, so at this level I switched from morning dosing to simply earlier than going to sleep dosing in order to not have an effect on my sleep. 8mg was carried out for 4 doses earlier than going as much as 10mg.
Security blood exams had been being taken periodically, and after the 4th dosing on 10mg these got here again displaying neutrophils had been under vary.
At this level we determined to cease and repeat all of the prior exams.
Must also level out that I used to be placed on Statins throughout this era, had detrimental reactions (muscle cramps) to a few differing types, so shortly switched to Ezetimibe and have been on this ever since. Additionally, in the direction of the tip of the interval, began taking 50mg Acarbose with carb laden meals.
Additionally, for no matter purpose and really annoyingly, one of many labs couldn’t do a number of the exams in order that they ended up having to be repeated after every week of having fun with myself snowboarding, overeating most likely garbage, not taking any dietary supplements other than the Vit D/Okay and taking an enormous hit on the hip which might be why the hsCRP went over the edge to register a quantity for the primary time since I’ve checked out it, and the APOB might be larger than it might need been 10 days earlier. (The APOB take a look at doesn’t correspond to all the opposite lipid numbers as now 10 days aside by way of blood draw).
Hooked up is the spreadsheet with some historic information going again to 2005 for reference, the pre-rapa information is in column H and the latest in column M.
Though Neutrophils shortly recovered, the explanation I stay off Rapa is that IL-6 and TNF-alpha grew to become very elevated and we’re but to resolve why this has occurred.
In any other case, no disregulation with glucose, Ezetimibe was clearly sufficient to cope with the prior elevated lipids and stopped elevation attributable to Rapa as reported by some others.
Over the interval my health regime didn’t change, and I’ve undoubtedly grow to be stronger on the gymnasium. All metrics improved. The ache in my finger joint grew to become unnoticeable and morning stiffness in each arms disappeared. DEXA and Vo2Max improved on all metrics.
Since being off Rapa, power stays, however joint ache within the finger is again together with the morning stiffness.
Via the entire interval I’ve been carrying an arm harm which hasn’t responded to remedy both on or off Rapa and likewise nonetheless beneath investigation just like the IL-6 and so forth.
Tru-Age seems to have improved in a single respect however not in one other (while DunedinPace just about unchanged under 0.7)
All in all I believe I conclude with the unique title of this thread.
Age calculations.xlsx (16.9 KB)
