Rapamycin and Train: any Muscle inhibition?

I ponder if rapamycin may need its results on muscle getting old by ceramide inhibition? Anybody extra acquainted on this subject, and whether or not there are any pure ceramide inhibitors?

I take 6mg Rapa with Evoo, 500mg Metformin and 50mg Acarbose Monday morning and wait till Wednesday morning earlier than I do my first of three WL weekly periods. Monday and Tuesdays I attempt to hold my protein consumption low and keep away from insulin spikes with a view to maximize mTOR inhibition. Pre Rapa, each morning, I used to do a 20min 180 levels Fahrenheit sauna session adopted by chilly plunge.
It appears that evidently Sauna will increase autophagy however on the similar time will increase mTOR and protein synthesis, however on the constructive facet chilly water reduces mTOR exercise.
As my morning sauna + chilly plunge session has such a constructive influence on the remainder of my day, I might very a lot respect any insights or recommendation

I’ve placed on muscle whereas on 4mg of rapamycin for 3 months. It’s very posible that I may have put extra had I not been on it, however the level stays : its attainable to placed on muscle mass whereas on rapamycin. See

My lean physique mass has elevated by 3% simply from studying Agetron posts. I admit that my rapamycin use is a confounding think about my N equals one.

I’m curious and look out for rapamycin and ceramide interactions too. However in the intervening time, that is out, on utilizing myriocin for ceramide inhibition on aged mice: https://scitechdaily.com/researchers-identify-a-new-hallmark-of-aging/

Zazim : My lean physique mass has elevated by 3% simply from studying Agetron posts.

Hahaha… what helped??? Curious.

Was within the fitness center at this time with a Marine buddy… beast of a man… 240 kilos 6ft. 4 in.

I advised him his mass is enviable.

His reply was … commerce it to your shredded look.

So there it’s.

Channeling well being and health your manner fellow guinea pig.

So I’m fairly positive 5mg/wk doesn’t inhibit VO2 max

(My knowledge on Coaching Peaks goes again to 2017)

Thanks for sharing, nice knowledge. Do you’re employed out on days taking Rapa ?

No, not sometimes (although I haven’t detected any variations once I do).

I monitor all of these items carefully. No change in resting coronary heart charge since beginning rapamycin and no change in resting coronary heart charge on the day I take rapamycin and the day following. Related outcomes for HRV. No change.

Some report anecdotally that they really feel sturdy and might have vigorous exercises after they hit the fitness center after having taken rapamycin. Others report anecdotally they really feel weak within the fitness center the times/the week after taking rapamycin.

There’s mTOR unbiased protein synthesis that isn’t inhibited by rapamycin. Citrulline is one substance that,may be useful for muscle constructing when in mTOR inhibited state. Why? One can speculate that it is because of elevated muscular perfusion and subsequent oxygen utilization? This may additionally be the mechanism by Viagra that retains the mind youthful and fewer vulnerable to alzheimers. In keeping with this “logic” it may be a good suggestion to make use of citrulline earlier than going to the fitness center after taken rapamycin.

In vitro:

“In conclusion, L-citrulline preserves charges of protein synthesis and protects myotubes from losing in a distinct method than L-arginine. We exhibit a novel direct protecting impact of L-citrulline on protein metabolism and skeletal muscle cell measurement that isn’t mediated by signaling by the mechanistic Goal of Rapamycin. As a substitute, we present these results are mediated by the inducible NOS (iNOS) isoform. That is the primary research to explain a dietary modulator of iNOS mRNA expression by skeletal muscle cells and will have vital implications for the therapy of muscle losing circumstances.

“L-CIT might enhance train capability by upregulating muscular perfusion and subsequent oxygen utilization.” “As well as, the motion of L-CIT on muscle perform additionally is said to its capacity to advertise muscle protein synthesis. “ “Future analysis remains to be wanted to decipher the contribution of endothelial versus neuronal NO manufacturing to the vascular and muscular advantages noticed after L-CIT supplementation”

My finest ever CP20 was 353w again in 2015