Earlier this month, Epibiotech CEO Jong-Hyuk Sung revealed an in depth new paper titled “Efficient and economical cell remedy for hair regeneration.” It was broadly coated in South Korean media (h/t “Theo”, who additionally despatched me this replace on Mr. Sung’s presentation overlaying the paper). They name him Seong Jong-Hyeok in that article.
My curiosity piqued after I learn such a radical scientific paper from a CEO (nearly exceptional on this business). I confirmed it to a well-known hair transplant physician, and he discovered it to be an important abstract. I additionally e-mailed one in every of Epibiotech’s media representatives with some questions, however no response thus far.
Adipose, Dermal Papilla and Dermal Sheath Cells
Notice that Dr. Sung has publiched quite a few papers on adipose-derived stem cells (ADSC) and hair regeneration (and wound therapeutic) for 15 years. This CEO appears to be a scientist at the start, somewhat than a enterprise individual.
This newest paper covers the three primary varieties of cell based mostly hair regeneration therapy methods which can be presently being developed:
- Adipose-derived stem cells (ADSC or ASC).
- Dermal papilla cells (DPC).
- Dermal papilla epithelial cup cells, higher kown as dermal sheath cup cells (DPSC or DSC).
The paper additionally mentions the manufacturing of hair organoids utilizing induced pluripotent stem cells. Together with a shout out to Dr. Takashi Tsuji.
- Notice that Shiseido (together with its use of Replicel’s know-how) is engaged on a hair regeneration therapy involving culturing of dermal sheath cup cells. Extra particulars right here.
- Additionally be aware that previously, Aderans and Intercytex each noticed some succes in hair development through dermal papilla cell culturing and injection into balding scalps. HairClone is presently making an attempt one thing comparable.
Dr. Sung’s firm Epibiotech is finally pushed by “Off-the-shelf” allogeneic DPC remedy. It goals to start Section 1 medical trials for its EPI-001 dermal papilla cell hair multiplication therapy in 2023. We’re all hopeful that issues will transfer quicker in Asia compared to the US or Western Europe. The corporate can already mass-produce dermal papilla cells with hair development capacity utilizing spheroid tradition, hypoxic circumstances, and development elements.
Adipose Derived Stem Cells
Given the creator’s background, the paper is particularly detailed relating to ADSC (ASC). Dr. Sung highlights the professionals and cons.
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- Adipose-derived stem cells are simple to entry and isolate in giant portions. This isn’t true relating to dermal papilla cells and dermal sheath cup cells.
- Whereas ASCs promote hair development via the paracrine impact, they’ve a poor potential in hair neogenesis. Dr. Sung suggests additional growth in strategies to boost the trichogenecity of ASCs.
Different New Research on Hair Regeneration
As if this was not sufficient, two new papers on hair regenearation got here out up to now month.
- A lierature overview from Japan coveres quite a few cell therapies for hair regrowth. This contains mesenchymal stem cell (MSC) implantation. Grownup sources of MSC embrace: adipose tissue (together with SVF); bone marrow; DPC; DSC; placenta and umbilical twine. The paper additionally analyzes non-cell therapies, together with exosomes, extracellular matrix, platelet-rich plasma, and the MSC secretome. The final talked about “includes bioactive supplies, comparable to development elements, cytokines and nucleic acids that play an necessary position in regulating the hair follicle cycle and regeneration”.
- A brand new examine from China on microenvironmental reprogramming of human dermal papilla cells for hair follicle tissue engineering.
- And at last, a latest video on regenerative medication for hair loss starring Dr. Jerry Cooley (interviewed by Dr. Robert Haber).
