A Pleasant, Organic Age Discount Competitors?

Essential declare, IF true

Most of my blood markers haven’t improved on rapamycin and I’ve been searching for markers that rapamycin improved. My MCV appears to be bettering. If I’m deciphering the outcomes appropriately, I’ve the MCV of a really younger individual. That is the primary optimistic change attributed to rapamycin that I’m moderately positive of.

Yeah, I like that 84 on the finish. Mine has not come near that.

In line with John, and logic, there’s a 120 day lag within the knowledge as a result of blood cells have to show over. So didn’t you give up for awhile? It appears to be like like there’s a small bump in Might or June, then a extremely steep slope down (for this measure) from there to the current.

It could possibly be simply noise, however an important graph anyway.

Sure, I did take a few 4 week’s pause round June of twenty-two.

The 84 implies actually good bone marrow and a great steadiness of micronutrients. I’m attempting to get a dependable measure of reticulocytes as effectively. I’ve some concepts about how one can enhance HIF 1 alpha and want to measure that with a reticulocyte rely, however I had an issue with the lab I used to be utilizing so I needed to change lab. I’ve now had two readings from the brand new lab, however I have to get a spread of reticulcyte numbers so I can work out whether or not I’m shifting the quantity or simply seeing regular randomness. Therefore I’m holding again once more though it could give me a spot inside which to take one other dose of Rapamycin.

That is attention-grabbing to see. Once you say a cup of contemporary grapefruit juice, is it an 8 fluid ounce cup or only one giant grapefruit you squeeze and wash down the rapa with? Additionally, do you eat proper earlier than or after you’re taking the rapa?

Hey Matt –

Appropriate, I purchase one good measurement Purple Grapefruit – prices about $1. I minimize it in half after which in quarters. I hand squeeze the items by way of slightly hand-held strainer to catch seeds and pulp.

It makes actually a juice-glass measurement quantity of fluid. So, approx. 6 ounces. I put it to the aspect and take my 3 rapamycin tablets that are 2mg every so 6mg whole. pop all of them in my mouth and swallow with the 6 ounces of contemporary Grapefruit Juice – GFJ. That’s it and I get a 5-6 instances magnification of my 6 mg dose which is 31-38 ng/mL. I’ve Labcorp examined this course of 3 instances and at all times the identical. So I don’t do the GFJ the morning of and an hour earlier than and with the dose and an hour after and the subsequent morning. Rattling that’s lots of GFJ – LOL. My contemporary squeezed 6 ounces of GFJ with the tablets is all I have to get my 5-6 improve – which is loads!

Additionally, the day of my rapamycin dose… within the night I often exercise resistance muscle coaching for an hour & quarter-hour – then have dinner a 1lb grilled steak (saturated fat) with a small salad and loaded baked potatoe and 12 ounce glass of complete milk about an hour or two earlier than I dose with the rapamycin and GFJ. Afterwhich, I’m going to mattress. I don’t exercise once more for 44 hours after dosing. At 44 hours I do my exercise and activate my MTOR2. That’s my N=1 routine each 10 days I dose as a result of excessive quantity of the rapamycin improve (5-6) … and works with my physique sort.

Respect the main points. Most likely gonna attempt some grapefruit with mine to economize.

Sounds good! It does save on tablets. Undoubtedly price setting it as much as get a LABCORP sirolimus check (blood draw) inside 1.5 to 2 hours after dosing to get an correct t-max of the dose in your physique!

Examine first, however anybody doing a draw ought to be capable of do that for you.

Simply bear in mind that individuals are getting wherever from 3X improve in bioavailability to 7X from grapefruit juice, so you could get some vital unwanted side effects.

That mentioned, in my expertise attempting GFJ it was high quality. I used to be taking rapamycin at 10 to 12mg/week, then went all the way down to 6mg with GFJ, and tried as excessive as 8mg with GFJ, and so successfully someplace round maybe 24mg of rapamycin (at that time I shifted to each two weeks), and completely no apparent unwanted side effects. So a minimum of for a few of us the results are fairly benign (although no blood assessments, so unsure of impact on lipids, however blood glucose was high quality by way of CGM).

The largest problem with regard to grapefruit juice is, I feel, the potential impression on every other drugs or dietary supplements you could be taking. If you’re taking something along with rapamycin you must be very cautious and work together with your physician, as a result of you’ll be able to shortly get to poisonous ranges of treatment (e.g. in lots of statins), for those who add GFJ to your pre-dosing routine.

Make sure to evaluate this: Enhance Bioavailability of Rapamycin (2)