viernes, febrero 14, 2025
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Chilly sores raging early on into rapa


Hello everybody! Apologies if this has been lined someplace (I searched the discussion board and couldn’t discover what I’m on the lookout for).

I’m a brand new rapa person. I’ve been taking 2mg per week for six weeks now. (I began with 1mg per week for 3 weeks). The issue is: each time I take it, the subsequent day I develop a chilly sore. I’ve all the time struggled with chilly sores (HSV-1), however by no means so intense and so typically. Is that this an indication for me to cease rapa quickly? To decrease my dose? Or is that this regular and one thing to energy by?

Any suggestions/expertise shall be drastically appreciated!




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jeu-de-paume, How are you taking it? Are you utilizing grapefruit juice, olive oil, plain water, a meal, and so on. This stuff might have an effect on how effectively it’s or will not be absorbed. For instance, grapefruit juice will a number of the absorption price to round 3.5 occasions regular absorption. In any other case, two milligrams definitely doesn’t sound like a lot. And, no, I’ve not seen this matter referenced wherever earlier than. I take capsules with keto espresso 30 to 60 minutes earlier than meals as a result of the oil within the espresso helps with absorption. Others take it with meals or a meal, particularly a fatty meal like bacon and eggs or the extra wholesome strategy with canned sardines.



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Thanks for replying! I’m taking it after breakfast, with grapefruit juice. I began with a low dose, as a result of I weigh 100 kilos – figured a bigger dose could be an excessive amount of for me.



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That’s nonetheless a fairly excessive dose for somebody who weighs solely 100lbs. It might be equal to 10mg. Folks right here see from 3X to 6x enhance in bioavailability with gfj.

I’d begin low at 1mg, and work as much as a goal of three or 4 mg not less than till issues are going effectively.

Debactorol is usually utilized by peter attia for mouth sores.



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jeu-de-paume, It’s only one particular person’s opinion, however I’d drop the grapefruit juice. I’ve been taking rapamycin for a couple of 12 months and I nonetheless don’t take it with grapefruit juice, both the evening earlier than, the morning earlier than, or with a dose of rapamycin due to grapefruit juice’s skill to a number of the consequences drastically. I’m going for gradual consistency of dosing in order that any issues skilled will seem slowly and permit me to simply readjust the dosage by the subtraction of a single tablet. Even at over one 12 months I’ve not discovered the precise dose I really feel shall be finest, however after I do I’ll experiment with grapefruit juice so I can cut back the variety of capsules and save slightly cash.



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It’s regarded as cytokine pushed. Some natural extracts like extremely absorbable turmeric, ashwagandha, boswellia, restrict pro-inflammatory cytokines. I don’t know if it could be sufficient to assist, although. A mix of those three herbs did assist to decrease cytokine irritation in covid sufferers. Made it to Section III hospital trials.

Within the second research beneath, a dexamethasone oral rinse was prompt as a remedy.



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I acquired my first chilly sore proper after beginning rapamycin too, fortunately I simply acquired it this one time regardless that I went as excessive as 12mg with grapefruit juice (I weigh round 75-6kg). You possibly can strive growing the dose a couple of occasions with extra time between doses and see if that works. I’d hold some acyclovir creme prepared in case you’re feeling a chilly sore arising



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Thanks for sharing your expertise (12mg, wow! I assumed something above 7-10mg crosses into ‘transplant’ doses? However I suppose it have to be particular person too. Replace: oh I see, you imply 12mg in the event you depend the juice in!)

Yeah, I’ve exhausted all my acyclovir provides (capsules and creme) since I began rapamycin! I usually retailer on these after I go to go to my household in Russia, since acyclovir is OTC there. I had a couple of 12 months value left, I assumed! But it surely all melted inside 2 months :smiley:
Fortunately I’ve discovered a few Slavic on-line pharmacies within the US, which is able to promote Ukrainian and Russian acyclovir/penciclovir meds with out prescription.



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Thanks for this perception! I’m gonna go retailer on turmeric/ ashwagandha/ boswellia :slight_smile:



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I did 12 mg with grapefruit juice equal to 36-40mg :wink:



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Do i recall accurately that chilly sores had been at or close to the highest of the listing of self-reported unintended effects for our group? I reported a couple of 3-fold enhance in incidence (labial) in an earlier survey for our group. I’m 190lb and had been taking a as soon as weekly 2mg dose with grapefruit juice. The elevated incidence occured a month or two after initiating Rapa. Not instantly. Now I take 2g of valacyclovir similtaneously the rapamycin however can’t report outcomes but. As mentioned right here by others, an elevated incidence of labial chilly sores would possibly enhance the chance of neurodegenerative illness based mostly on varied uncontrolled and cross-sectional studies. FWIW i’ve modified my dose to 4mg Rapa with out grapefruit juice plus concomitant 2g valocyclivir. As an APO-e4/e3 genotype and with a uncommon seizure situation, having an elevated threat of chilly sores on this routine will trigger me to scale back the dose additional, presumably to cease if it nonetheless will increase my chilly sore incidence.



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Sure – mouth sores are by far the most typical facet impact folks see – with 37% of our customers reporting this difficulty not less than as soon as: Rapamycin Consumer Ballot / Survey – Please Reply – #3 by RapAdmin

Is it value having the surveys acquire individually canker and chilly sore unintended effects?

I can’t consider any vital advantages for that stage of granularity on the unintended effects, however maybe another person can.

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