Chilly sores raging early on into rapa

Hello everybody! Apologies if this has been coated someplace (I searched the discussion board and couldn’t discover what I’m searching for).

I’m a brand new rapa person. I’ve been taking 2mg per week for six weeks now. (I began with 1mg per week for 3 weeks). The issue is: each time I take it, the following day I develop a chilly sore. I’ve at all times struggled with chilly sores (HSV-1), however by no means so intense and so usually. Is that this an indication for me to cease rapa quickly? To decrease my dose? Or is that this regular and one thing to energy by?

Any suggestions/expertise can be significantly appreciated!

jeu-de-paume, How are you taking it? Are you utilizing grapefruit juice, olive oil, plain water, a meal, and so forth. These items could have an effect on how nicely it’s or just isn’t absorbed. For instance, grapefruit juice will a number of the absorption charge to round 3.5 instances regular absorption. In any other case, two milligrams actually doesn’t sound like a lot. And, no, I’ve not seen this subject referenced wherever earlier than. I take tablets with keto espresso 30 to 60 minutes earlier than meals as a result of the oil within the espresso helps with absorption. Others take it with meals or a meal, particularly a fatty meal like bacon and eggs or the extra wholesome strategy with canned sardines.

Thanks for replying! I’m taking it after breakfast, with grapefruit juice. I began with a low dose, as a result of I weigh 100 kilos – figured a bigger dose could be an excessive amount of for me.

That’s nonetheless a fairly excessive dose for somebody who weighs solely 100lbs. It may very well be equal to 10mg. Folks right here see from 3X to 6x enhance.

I’d begin low at 1mg, and work as much as a goal of three or 4 mg a minimum of till issues are going nicely.

Debactorol is often utilized by peter attia for mouth sores.

jeu-de-paume, It’s only one individual’s opinion, however I’d drop the grapefruit juice. I’ve been taking rapamycin for a couple of yr and I nonetheless don’t take it with grapefruit juice, both the night time earlier than, the morning earlier than, or with a dose of rapamycin due to grapefruit juice’s means to a number of the consequences significantly. I’m going for sluggish consistency of dosing in order that any issues skilled will seem slowly and permit me to simply readjust the dosage by the subtraction of a single capsule. Even at over one yr I’ve not discovered the precise dose I really feel can be greatest, however after I do I could experiment with grapefruit juice so I can cut back the variety of tablets and save somewhat cash.

It’s regarded as cytokine pushed. Some natural extracts like extremely absorbable turmeric, ashwagandha, boswellia, restrict pro-inflammatory cytokines. I don’t know if it could be sufficient to assist, although. A mix of those three herbs did assist to decrease cytokine irritation in covid sufferers. Made it to Part III hospital trials.

Within the second examine under, a dexamethasone oral rinse was steered as a therapy.