viernes, febrero 14, 2025
InicioAnti AgingYamu Xu co-founder of Lifereversal - Dietary supplements

Yamu Xu co-founder of Lifereversal – Dietary supplements


Is anybody accustomed to his work? He takes dietary supplements I’ve not heard of here’s a excerpt from a publish I discovered on Quora:

Lithium salts have a aspect impact, which is that it damages the kidney . Is there a option to cut back the uncomfortable side effects of lithium salts?In line with associated analysis, N-Acetylcysteine ameliorates lithium-induced renal failure in rats.

(I often take lithium with glutathione, NAC, glycine and betaine to guard liver and kidney )

In line with A triple drug mixture concentrating on parts of the nutrient-sensing community maximizes longevity, rapamycin therapy ends in insulin resistance and dyslipidemia in sufferers and mice, and this disturbance manifests as hypertriglyceridemia in Drosophila. Lithium reversed this and the hunger resistance related to rapamycin therapy. On this examine, double mixtures of lithium and rapamycin, lithium and trametinib, or rapamycin and trametinib produced a reproducibly larger lifespan extension than controls, on common 30%, in comparison with every compound alone, which prolonged lifespan by a mean of 11%. Remarkably, the triple drug mixture elevated lifespan by 48%.




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Will we now take lithium, trametinib, and rapamycin collectively?

As

FWIW within the US a prescription of 2mg of Trametinib {Mekinist] 30 pill is round $13,050.00 with a reduction coupon {17% off the typical retail worth of $15,826.00

The India model is barely ₹72,000 round $870.00 USD

And as a aspect impact it clears up any melanomas you may need.

This appears to be the examine he primarily based his routine on:

https://www.pnas.org/doi/10.1073/pnas.1913212116

A triple drug mixture concentrating on parts of the nutrient-sensing community maximizes longevity

Jorge Iván Castillo-Quan ORCID, Luke S. Tain, Kerri J. Kinghorn, +5, and Linda Partridge

There isn’t any assurance{that trametinib/mekinist]
will “clears up any melanomas”.

Connected is a PDF copy of the paper.

A triple drug mixture concentrating on parts of the nutrient-sensing community maximizes longevity.pdf (702.5 KB)

$870 per dose? Cheapo me will attempt the pure various.

Cranberries are the very best supply, however mg content material is minuscule. So I’ll attempt the complement. Amazon sells 100mg myricetin tabs for $20 per 60 tabs.

Trametinib is a MEK inhibitor, and so is myricetin.

2mg of Trametinib {Mekinist] 30 tablets

From India $870.00

A US stuffed prescription $13,050.00. The typical retail price within the US is $15,826.00*

*Novartis is have a troublesome time, they should recuperate all their price.

Okay. $29 per dose, versus $20 per bottle of myricetin. Proof up to now, is on flies. I’ll persist with the cheapo shot.

If therapy of most cancers is the goal, not longevity, combining with modified rice bran could also be stronger.

That examine had just one affected person.

“In a now 59 years outdated affected person with inoperable (BRAF-mutant) low differentiated adenocarcinoma of bilary ducts after 30GY radiotherapy and two cycles (Gemcitabin+ Cisplatin) chemotherapy a speedy development of lung, liver and mind metastases have been by CT and MR established. Thereafter, a teatment with BRAF+MEK inhibitors (2×150 mg dabrafenib and 1 x 2 mg trametinib) was began. These inhibitors have been mixed with day by day 45 mg/kg rice bran arabinoxylan focus (utilizing Biobran/MGN-3) which was proven to be a pathogenic related molecular sample (PAMP)-like molecule and might stimulate the type-1 innate immune cells in opposition to tumor cells.”

“Outcomes: After the chemotherapy and previous to the beginning of second line therapy, the affected person had a virtually terminal state of her quickly progressive illness. Eight months after the mix of MEK / BRAF inhibitor and immunomodulator remedy practically full remissions of all metastases was established in CT and MR.”

Of us, I believe that no person must be taking a complement routine primarily based on ends in flies…

From the paper talked about above…

“additively to extend longevity in Drosophila

Please don’t begin taking medicine and dietary supplements primarily based on a lot of these outcomes… its attention-grabbing, however we want much more proof in mammals earlier than contemplating it.

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