Yet one more rapalog (37 M) – rapamycin

Background:

37M, usually in good well being. Train frequently (weights and cardio) and eat a average low-carb(ish) food regimen. Not a lot to touch upon right here.

Current dietary supplements:

Vitamin D – 5000iu 3x // week throughout winter
Acetyl-Carnitine — 1-2g, 5x per week
KSM-66 ashwagandha — 600mg 4-5x per week (or as wanted for stress)
NMN – 250mg-500mg every so often once I want an power enhance. I do discover this works for me acutely higher than chronically.

I had began astaxanthin once more however dropped it as I didn’t wish to change any variables from what I had been taking beforehand.

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Week 1 (Monday, Dec 5):

I’m scripting this retrospectively, I took 2mg with 6mg piperine (inhibitor of CYP3A4). I seen some fatigue later within the day and took a nap. Felt nice the following a number of days.

Maybe noticing some elevated soreness from train within the days following. Not fairly as a lot power within the gymnasium for a day or two.

General fairly delicate results, assume I perhaps psyched myself out.

Week 2 (December 12):

Took 5mg this morning with 12mg piperine. Felt extra comfy bumping the dosage after I didn’t actually react to 2mg. Would possibly change to grapefruit juice however I hate the stuff and I’ve piperine available. It’s a bit unclear to me how a lot the piperine will increase the absorption although, I’d somewhat have some concrete numbers. In all probability finest to get a blood degree sirolimus take a look at sooner or later.

Noticing delicate fatigue once more. Actually appears fairly delicate although, if I didn’t know that I took rapa right now I most likely wouldn’t have seen a lot.

Will proceed taking it at this dosage (5mg // week, doubtless with some form of absorption enhancer).

Bloodwork to observe within the subsequent couple weeks. I’ve had no unwanted side effects to date, nevertheless it’s fairly early so I’ll replace if that adjustments.

Cheers,

Thanks for this. I’m beginning quickly as effectively (40M). I simply have to chew the bullet and get my blood work achieved beforehand. I abhor needles lol.

Thanks for sharing these particulars. I’ve additionally seen delicate fatigue within the gymnasium for 2-3 days after dosage. Grapefruit juice has not me due to the variability between manufacturers of juice, sorts of grapefruits, and variable dosage in the event you’re truly consuming a grapefruit. Piperine appears like a doubtlessly more sensible choice. For those who get a blood take a look at on the dosage with piperine I’ll have an interest to listen to the outcomes. How did you arrive on the rapa::piperine ratio of two::6 and 5::12? Do you’re taking your dose with excessive fats too? Better of luck going ahead!

Quercetin is one other potent inhibitor of CYP3A4 if you need an alternative choice. From what I’ve rapidly scanned, it needs to be almost as efficient as grapefruit juice. 55% inhibition in comparison with 67% from bergapten, the flavonoid in grapefruit juice which inhibits CPY3A4.

GFJ could also be stronger although as a result of it has two flavonoids which inhibit that enzyme, nevertheless it’s not as standardized as a effectively sourced quercetin complement.

https://websites.ualberta.ca/~csps/JPPS4(3)/S.Wanwimolruk/grapefruit.htm

Grapefruit juice is meant to be taken 2-4 hours earlier than rapa dosage and pagans together with the dosage, as I perceive it.

Would it not be your thought that Quercetin needs to be taken in the identical window of 2-4 hours earlier than rapa dosage? Not on the lookout for medical recommendation, simply your private opinion.

IMO, sure 1-2 hours earlier than, most likely with some meals so the powder can disperse from the capsules adequately. That’s only a guess.

edt positively with meals or some type of fats as a result of it’s not water soluble.

I combine it with EVOO for absorption.

First, to reply to some earlier questions:

1. I take rapamycin with breakfast, which generally consists of some almond butter or fats supply. Not an extreme quantity, nevertheless it’s with a meal.

2. Concerning piperine, I want I had higher information, however the actuality is we’re flying blind with any form of absorption enhancers except we get a blood take a look at (which I do plan to do sooner or later). If rapamycin provide is limitless, I feel it’s finest to titrate the dosage of rapa itself versus tinkering with piperine // grapefruit.

3. I’m taking piperine concurrently with the meal // sirolimus, nevertheless I could change to taking it 30-60 minutes prior.

Onto the log:

Week 3 (December 19):

Took 5mg about Half-hour in the past with 30mg piperine. My log is a bit clouded the final week as I’ve had two points come up:

1. I had a minor chilly which began across the starting final week’s dosage (principally gone now)

2. Opposite to many individuals’s experiences right here, I exacerbated an current damage and have been unable to weight prepare as I’d like. I’ve been doing a little cardio, regardless of being barely sick I used to be in a position to put up some good numbers for that relative to my latest historical past.

So my well being has been marginally worse over the previous week, though it’s very doubtless coincidental. I’ve seen zero unwanted side effects associated to pores and skin, mouth sores, and so on. What I’ve seen is a way of malaise about 3-6 hours after dosing, which then turns right into a form of power // stimulation. It’s nonetheless very early for me to essentially be certain about something although, the consequences are far milder than I had initially anticipated. I’ll replace as as to if the acute results of the third dose match the earlier 2 doses. Maybe my physique is simply adjusting the drug.

The plan is to proceed on this dosage for some time (30mg piperine // 5mg rapa) and see how issues go. TLDR is I really feel good, no main sides good or dangerous.

Edit // Fast replace:

No actual fatigue right now. Did some cardio HIIT (not that intense, however nonetheless fairly tough and winded) and felt nice. May’ve gone more durable however didn’t wish to do an excessive amount of the identical day as rapa till I’ve extra expertise with the drug.

I do discover one thing from acute rapa dosing, it’s simply arduous to explain. There’s a noticeable anti-inflammatory feeling, and my head feels clear. Possibly a slight blunting of urge for food.

Cheers,

I took 5mg of Sirolimus this morning, together with 30mg piperine and a breakfast containing some fats and protein. This time, the 30mg piperine was taken roughly 20-Half-hour earlier than the meal.

Some notes concerning final week:

Sides:

1. I’ve seen barely elevated flatulence/fuel all through the week. I’d say that is the one noticeable aspect impact up to now, and it’s fairly delicate. I do assume it’s doable that it’s associated to rapamycin.
2. Two tiny mouth sores that resolved in a matter of hours. Actually, if I weren’t on the lookout for mouth sores I most likely wouldn’t have even seen.

Advantages:

1. My sleep effectivity rating (as measured by way of oura) appears to be improved, significantly days 2-4 after dosing. Usually, I’m waking much less throughout the night time and once I do wake, it’s simpler to fall again asleep.
2. Subjective, however usually feeling fairly nice.

Impartial:

1. I haven’t been lifting (rehabing an damage) however my cardio endurance appears unaffected, even on dosing days. I plan to do HIIT right now.
2. I haven’t seen a lot when it comes to physique recomposition, however I haven’t misplaced a lot muscle regardless of not lifting. I truly assume it’s believable there’s virtually a muscle preservation to rapa, however that is extremely subjective.
3. I haven’t seen any stressed sleep the primary night time after dosing as some individuals have. I’ve been taking a small quantity (0.5 mg) of melatonin on dosing nights simply in case nevertheless.

Cheers,