35 Yr Outdated Lively Dude needs to provide rapamycin a shot, what metrics to trace?

I’m a 35-year-old energetic male (Exercise 4/5 per week), have a comparatively nutritious diet (I eat carbs however typically eat a clear, well-balanced food plan), and Sauna 5/6 occasions per week. I’ll attempt rapamycin, however I had some considerations and questions earlier than beginning.

1. I do quite a lot of BJJ and have caught staph a couple of occasions; whereas the an infection is prevalent amongst grapplers, I don’t need to cope with a weak immune system, and therefore am occupied with rapa 2 occasions a month as a substitute of each month. Would this make sense? Pondering of beginning 6 mg each two weeks and upping to 12mg.
2. What metrics ought to I monitor earlier than and after? I’m considering of getting blood work executed each 3 months however I don’t know what ought to be adopted.
3. Ought to I restrict my carb consumption? Actually, being very energetic, I can’t depend on a keto food plan at this level and am terrified of creating insulin intolerance.
4. I’ve a previous historical past of a small (5mm) rectal carcinoid, whereas in keeping with my GI’s it’s not a giant threat, I WILL BE at extra threat for creating most cancers than somebody who has’t had this.

Hello Ali, and welcome to the discussion board. As you already know your entire space of rapamycin use remains to be very a lot in its infancy in relation to longevity purposes, so we’re all in a studying mode right here. My basic suggestion is to do as a lot pre-and submit testing as is sensible for you and your finances.

Listed here are some good discussions to get you in your approach:

Dosing: What’s the Rapamycin Dose / Dosage for Anti-Getting older or Longevity?

Metrics to trace: New Rapamycin Consumer, looking for recommendation and finest practices
Extra metrics: Assist with organising an N=1 research
Extra metrics dialogue: One other Introduction – 56 Yr Outdated Well being Fanatic
Extra: Monitoring your Rapamycin Outcomes – From the PEARL Research

Look ahead to widespread unintended effects: Facet Results of Rapamycin (half 2)

Look ahead to widespread advantages: Anti-aging Advantages of Rapamycin, Private Experiences (half 2)

Please report in your journey.

Most of us don’t do a Keto food plan, however many people average easy carbs like sugar, junk meals, and many others.

Overview the FAQ as a lot as you’ll be able to: Rapamycin Regularly Requested Questions (FAQ)

Took 2mg as my first dose on Saturday. Not many “noticeable” advantages, I do have a much bigger urge for food tho I’d say, was scared that my sleep will likely be impaired, and that has NOT been the case thus far. I did my bloodwork per week in the past and can add the outcomes as quickly as I get them. Hopefully, I’ll do my subsequent spherical of blood work 4 months from now to measure the modifications.

Ali, you should definitely take the rapamycin early within the morning… that appears to attenuate threat of sleep disruption for many individuals.

Actually, from my expertise rapamycin taken late within the afternoon or night may be a great way to get extra work executed if it’s good to work late one night time… I didn’t get to sleep till one thing like 4am the time I took rapamycin at 9pm.

Additionally – because you first posted we had a brand new person submit his earlier than and after testing protocol. I encourage you to overview it as a result of I feel its a extremely good strategy to implement a pre and submit testing protocol – although I’d counsel a 6 month interval between pre-test and post-test simply to see extra of a distinction over time. 3 months is a fairly brief interval. See right here: My Lab and Health Outcomes After 3 months of Rapamycin Use

Thanks. I did take it the primary week within the morning and can proceed to take action given what I’ve examine its results on sleep.

Took my 4 mg on the weekend. It has been 14 days since my final dose, and I plan to remain at 5 mg each different week. My Insidetracker outcomes got here again displaying my precise age, three years youthful. I’m planning to take a second take a look at round 4 months from now. My observations thus far:

1. Sleep has had no modifications. I sleep properly.
2. I’m approach weaker in grappling. I don’t know if that is associated, however virtually everybody I used to beat up per week in the past was wiping the ground with my face.
3. My gums usually are not as bleeding as a lot when brushing my enamel, however for this to be associated to rapa I must have a couple of extra knowledge factors.I’ve heard about improved gum well being on rapa however do must confirm by myself.

I’m 37m right here additionally fairly energetic. Been on rapa for 3 months. Advantages of rapa accumulate over time IME. Greatest one is simply sounder sleep. My sleep effectivity as measured by Oura has gone up 3-4%, from 84 to 88-89.

Ha.Attention-grabbing.
What’s your dosing schedule like?