I’m planning on the steered 1 mg, then growing 1mg/wk till 6-7/weekly. Does time of day, empty/full abdomen or with grapefruit juice affect availability or uncomfortable side effects? I’ve seen various views all through the threads. Thanks everybody for any enter.
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To me it comes right down to a cash profit vs ease of following the extensively accepted dosing vary.
I feel if you happen to’re going to make use of gfj, one ought to both be vigilant about discovering peak and trough ranges while you dose it that approach, or maintain the dosing decrease and assume no less than 3.5x improve in serum focus. Ideally do the previous although.
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I’m very curious what others advocate. I plan to go biweekly and improve slowly by 1.5mg equal per dosing till 3mg+GFJ.
Im going to imagine a 3x multiplier for the GFJ.
So
1.5mg
1mg +gfj
1.5mg + gjf
2mg +gfj
2.5mg +gfj
3mg + gfj
Adopted by a month off + reappraise primarily based on uncomfortable side effects and/or perceived advantages
Finally I’d like to attain 5mg + gfj month-to-month as a result of that appears (primarily based on anecdotal knowledge gleaned from this sensible web site) to attain the 30ng/ml blood serum stage regarded as an vital threshold for blood mind switch
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3X is an efficient assumption for the impact of GFJ.
1.3X is an efficient assumption for taking Rapamycin with excessive fats meals like EVOO.
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I’ve by no means seen any reference for one thing like this. Do you’ve gotten one?
Hello, You’re completely proper to drag me up on this. I used to be basing it on one thing mentioned by Blagosklonny, slightly than any precise knowledge.
I see you’ve seemed on the foundation for Blagosklonny’s dosing assumptions right here
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Are you aware in the event that they’re multiplicative?
Not multiplicative however synergistic. I’m not conscious of the entire multiplier, however no matter it’s, it can’t exceed 10X. My guess is collectively they’re between 3.3X and 4X.
