Acarbose Dose That Of us are Taking?

I neglect… however sure my two earlier physicians angle was … you’re doing good on your age. Getting previous is inevitable… simply go together with it. The gradual dying spiral. lol.

Why I modified to a brand new youthful physician 3 and half years in the past.

Are any of you utilizing the Hibose model from Kachhela? I took 4 x 50mg immediately (first day taking it) didn’t discover a lot

What my physician prescribed.

Libertas Pharma Inc.
Accommodates: Magnesium stearate, silicon dioxide, microcrystalline cellulose, corn starch.

I’ll ask my physician for a prescription subsequent time I’m in however I don’t have an appointment for a number of months so within the meantime working with the India Hibose

Has anybody right here tried out utilizing a mix of miglitol and acarbose with rapamycin? It apparently works higher than acarbose since it’s a monosacharide as an alternative of a tetrasacharide like acarbose. So it might probably truly be absorbed into the bloodstream. Supposedly works higher than acarbose for metabolic syndrome. I assume it has the identical longevity profit as acarbose mixed with rapamycin. I used to be going to take 50mg of each miglitol and acarbose at each meal along with the 5mg of rapamycin I take weekly. The literature appears to be fairly conclusive that miglitol is superior with respect to physique weight discount, decreasing a1c, and blood glucose. Additionally seems to extend glp1 which is a pleasant bonus. I’m at a 28 bmi (6’4″ 220lbs) and can drop miglitol and orlistat as soon as I attain a bmi of 25. I might like to see if Wealthy miller would take a look at miglitol in combo with rapamycin. Marvel if the impact could be extra than simply additive?

That’s fascinating, amongst 3 alpha glucosidase inhibitors (miglitol, acarbose and voglibose), miglitol reveals essentially the most weight‐decreasing impact. And sufferers with sort 2 diabetes mellitus switching from the very best accredited doses of acarbose or voglibose to a medium dose of miglitol have a extra steady glucose fluctuations.

Evaluating the GI uncomfortable side effects of Acarbose and Miglitol, it appears like Acarbose produces fuel extra, Miglitol causes diarrhea extra, Acarbose will increase unabsorbed polysaccharides which result in flatulence and belly bloating, nevertheless Miglitol will increase unabsorbed disaccharides which result in osmotic diarrhea.

I don’t know if folks has mixed Acarbose and Miglitol, if GI signs of mixing 2 medicine are tolerable, I could give it a attempt, and I might like to see if Wealthy miller would take a look at miglitol in combo with rapamycin too.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023585/

https://sci-hub.se/https://pubmed.ncbi.nlm.nih.gov/20558922/

Sure please submit for miglitol Utility Directions | Nationwide Institute on Growing old

We don’t know whether or not different medicine in the identical class aside from acarbose may lengthen the lifespan in mice or whether or not it could translate to people. It may “work higher” or “worsen” or “null impact”.

There are recognized variations in miglitol in people. If acarbose works in people, there could also be completely different alterations within the microbiome/absorption of bacterial merchandise, as urged with the doable aspect impact of delicate elevation in hepatic enzymes regardless of acarbose being primarily non-systemically absorbed – this isn’t seen in miglitol and miglitol truly is systemically absorbed. However it might be useful to make use of a number of completely different chemical courses (I’m not betting on miglitol) to keep away from “acarbose resistance”.

If acarbose resistance occurs, it might be the case the place the mice ITP research could not apply in any respect in the event that they even do.

I simply fast previewed the acarbose resistance on this paper, however I’m not deep into the mechanism behind it. Is acarbose resistance reversible and do you’ve got methods to forestall acarbose resistance?

Within the ITP mice sutdies, they used a lot excessive dose acarbose, 400, 1000, 2500 mg per kg food plan (ppm) from 8 months of age.Underneath such excessive dose, I’m wondering if the mice already had acarbose resistance?

Some intestine micro organism develop methods to disable acarbose so different competing micro organism get much less meals. The fundamental premise is to make use of a number of kinds of inhibitors, much like utilizing a number of antibiotics to keep away from resistance, besides the inhibitors from food plan I take advantage of have a excessive security profile.

May you elaborate on “inhibitors from food plan”?

My acarbose arrived from India immediately. Simply began small with a 25mg dose with my first chunk of a gomacro outmeal protein bar. I’m going to make use of my CGM to see how this appears versus final time I ate one with out. Will submit when I’ve the info.

Glorious.
Been on Acarbose for about 3 months.
Simple on my intestine in comparison with Metformin for me.

Preserve us posted.

Hey @Agetron how usually and at what dose are you doing it?

Btw: No fuel or GI, unsure when of us acquired that however I’m 3 hours faraway from taking and consuming.
Attention-grabbing how my glucose spiked and insulin kicked in second graphic versus first. The large spikes had been sans Acarbose. I ate the identical protein bar in each from a fasted state.

I take a 50 mg pill with the primary chunk of a meal. Sometimes 3 meals a day morning – midday – evening.

I do get a little bit gassy once I additionally take a combo of a Probiotic with Kefir (liquid yogurt).

In any other case, no difficulty. Bowel actions are wonderful, stable – and infrequently.
Abdomen feels nice with Acarbose – no heartburn – even with pasta & tomatoe sauces or spicey Mexican. Eat after which exercise – no drawback.

Assume I’m going to attempt bumping my dose as much as 200mg of Acarbose at a time based mostly on Bryan Johnson’s protocol