Any rapamycin inquiries to ask Matt Kaeberlein?

This week I’ll interview the Rapamycin researcher Matt Kaeberlein for the podcast. Are there any questions you need me to ask him?

His opinion on that paper

I ponder if the query may very well be reframed so it’s extra simpler to for a listener to soak up the query. Any solutions the right way to ask the questions with out complicating issues? Like “Is there any dangers for individuals with sort 2 diebetes to take rapamycin?”

“Rapamycin Will increase Mortality in db/db Mice, a Mouse Mannequin of Kind 2 Diabetes. Is that this related for people taking rapamycin for longevity? “

If he needed to steelman the anti rapa camp, what’s the most compelling explanation why NOT to take rapa?

Do now we have any data of rapa impact constructive/destructive on ckd and kidney perform (kidney stones, since they appear to typically begin in somebody’s 30’s, so its most likely considerably age associated)

Any concepts by way of taking rapa for a time frame after which stopping, if that creates any lengthy final modifications

Any updates on optimum dose/frequency
generic vs rapamune

I actually just like the query about switching completely view and take a look at the weak factors of Rapa

Does Matt have a listing (or a hyperlink to a listing) of veterinary medicines for canine that may have a destructive interplay with Rapamycin?

He has stated beforehand that he considers everolimus to be equal to rapamycin. Nevertheless they seem like dosed in a different way. What dose of everolimus can be equal to rapamycin?

Can he discuss somewhat about weekly vs. biweekly dosing, what are the advantages and disadvantages with every dosing technique?

I wish to know whether or not he’s utilizing a rapalog in his canine research, and if sure, is that this one thing he’s creating as a possible product?

I don’t suppose its a rapalog he’s utilizing. However somebody right here most likely can confirm that.

The query as framed appears high-quality. If the listener can’t sit by way of Kaeberlein responding to a query about animal information, she or he shouldn’t be remotely excited about any potential anti-aging results of rapamycin, since that’s the place all the info come from. Definitely they shouldn’t be contemplating utilizing the stuff.

This.

(Apparently the discussion board software program gained’t let me put up lower than 20 characters).