@Bicep please don’t heed any recommendation from this wacko.
His data on isopropanol is exrtremely uninformed an inaccurate, as he appears to simply willy-nilly Google shit with out even bothering to READ THE SCIENCE!
For example, that is factually incorrect:
He simply googled “isopropanol LD40” and the primary results of that’s dermal LD50 on rabbits, which is 12.8 g/kg. That isn’t oral LD50, and it definitely isn’t injected LD50 which gives much more bioavailability than oral (that means a smaller dose is the same as a bigger oral dose).
In the event you evaluate that to the oral LD50 of ethanol, which is 7-12 g/kg in mice, then you possibly can see how Dan got here to the conclusion that isopropanol’s LD50 is twice that of ethanol. That’s incorrect.
The reverse is definitely the case – isopropanols oral LD50 in mice is ~5 g/kg. In different phrases, the LD50 of isopropanol is half that of ethanol.
Anybody with primary data of biochemistry is aware of why – longer chained alcohols produce metabolites which can be more and more poisonous to the physique. The identical goes for the other way with methanol, having one carbon atom fewer than ethanol, which metabolizes to formaldehyde in your physique.
Isopropanol fortunately doesn’t metabolize into something as horrible as formaldehyde, however it’s prevented in pharmaceutical preparations for a lot of causes. For one, as a result of ethanol exists! Isopropanol comes with way more unwanted side effects than ethanol, which is why it’s prevented every time potential. The one cause Dan makes use of it’s as a result of he actually buys 70% rubbing alcohol from Walmart. Not joking. Right here’s his put up:
Moreover, the paper he’s citing that makes use of isopropanol is a purely explorative developmental examine. In different phrases, simply proofs-of-concept. They weren’t even examined on mice, simply cell traces.
These formulation research are completed as an illustration to say “hey it’s potential,” not as a direct-to-pharma preparation. For fuck’s sake, Dan, it says FORMULATION DEVELOPMENT within the title! Together with the phrases “Toxicity and Evaluation!”
However you deliberately disregarded that final a part of the title. The complete title is:
Rapamycin-Loaded, CapryolTM 90 and Oleic Acid Mediated Nanoemulsions: Formulation Improvement, >>>Characterization and Toxicity Evaluation<<<
I don’t know if you’re being deliberately deceitful by omitting such an essential element, being that it is a toxicity examine. I don’t know in case you’re simply ignorant or maliciously making an attempt to trigger hurt to others on this discussion board by spreading misinformation. However to be sincere, each circumstances are equally as unhealthy.
It’s typically the individuals who refuse to hunt fashionable, science-based medication that find yourself reintroducing measles to the world.
I don’t know why you could have a grudge in opposition to medication. I’ve my very own grievances in opposition to the system, however it’s virtually totally as a result of regulatory restrictions that hinder medication, not the drugs itself.
That’s precisely what you are doing. You’re throwing out all of those wildly incorrect, demonstrably false information which have no citations, no proof, and no reasoning aside from “for the kicks.”
You could have rejected each single quotation, reality, and proof that I’ve offered you. You appear to simply imagine what you need to imagine, not primarily based on proof, however on what you’re feeling.
And also you aren’t profitable. You injected your self with non-sterile tapwater from the Philippines and use Walmart rubbing alcohol in your injections, too. And shock shock, you bought an an infection from that!
Shallow and trite? So this assertion of factual medical actuality, is shallow and trite? And never backed by proof? Are you joking?
No, it’s NOT extra possible! The place are your sources? Your math?
That is demonstrably false!
An estimated 1.3 million lives within the US are misplaced resulting from unsafe injection practices, principally associated to opiates and drug abusers (which can suit your description, given your previous psychedelic/ketamine injections).
Examine that to annual automobile-related mortalities within the US in 2020:
A complete of 35,766 deadly automotive accidents for 2020. Because you received’t do the mathematics, I’ll do it for you:
Your unsafe injection practices make you 36 occasions extra more likely to die than automotive accidents. Now, let’s issue within the estimated variety of injection drug customers inside the US, which was projected to be about 3,694,50 in 2018:
Now, not all of those individuals who inject medicine (PWID) accomplish that in a harmful and abusive method, however allow us to assume the worst case state of affairs that all of them are drug abusers.
Which means you could have an annual danger of injection-related demise of roughly 1 in 3 PWID. I hope you possibly can see now why unsafe injections are such a disaster within the US and worldwide. It kills so many individuals that we actually have to brush useless individuals off the streets in lots of cities of the US. This is likely one of the the reason why cities like LA are such hellholes these days.
Which is why we have now to take a look at the info and do the mathematics. What you’re doing, as I’ve calculated, isn’t one thing that may occur. It’s extraordinarily possible to occur, particularly in case you proceed this conduct. This is the reason I’m telling you to hunt medical counsel. You want each psychological care and drug rehabilitation.
No, it’s the reality you don’t realize it that demonstrates to me your lack of expertise on what you’re doing. You bragged about having the ability to do a easy highschool derivation of calculus as if that makes you an skilled, but you possibly can’t even acknowledge some of the primary of pharmaceutical equations.
That equation was for plasma focus, by the way in which. The actual fact you didn’t even hassle to Google it speaks volumes of your willingness to really analysis and validate data.
Quantum stage organic chemistry? What the hell is that? Do you even know what you’re speaking about? I hope you aren’t being critical.
They aren’t “realize it alls,” the one one performing like a know-it-all is YOU. And like I stated earlier than, these medical doctors clearly know derive a easy calculus equation. Whereas you can not even acknowledge the plasma focus method, a damned introductory pharma equation that you would’ve Googled. I didn’t even ask you to resolve it, or derive it, simply to call it. And also you didn’t.
Danny boy, after they inform you to not inject your self with faucet water from the Philippines, maybe it is best to pay attention.
Now let me flip one in every of your one-liners unto you.
I requested you to call a primary pharma equation, and also you couldn’t provide you with a solution on the spot. What does that say about what you know?
