Anybody making an attempt one thing a bit of extra edgy?

Hiya everybody,

I needed to start out a dialogue on whether or not anybody right here is experimenting with “edgy” longevity protocols. By “edgy,” I imply protocols which might be extra experimental or unconventional than what’s at the moment accessible within the mainstream longevity group and what most of us listed below are doing (I.e. Rapa + x,y,z and so on.).

I’m curious to know if anybody on this discussion board is experimenting with something they could take into account comes beneath the umbrella of “edgy” or if you already know of every other unconventional approaches that aren’t but extensively recognized.

What are your ideas on “edgy” longevity protocols? Have you ever tried any your self?

Follistatin in Honduras in all probability falls in that class

Simply questioning the way you got here throughout this one @forceofnature ? Have you ever tried this in any respect?

I’ve not personally. I used to be conversant in the thought from years in the past after which got here throughout this thread within the discussion board just lately

In some ways Rapamycin is kind of “edgy” in that it suppresses the immune system. I believe individuals attempt a variety of issues. I’m fairly prepared to experiment with issues that appear cheap, however I do a weekly blood take a look at significantly to see if I’m doing any hurt.

I’m not certain I’d describe any of the issues I do as being significantly edgy. I do infrequently take a number of melatonin. Nevertheless, though some individuals say an overdose is over 20mg, my expertise is that this isn’t true.

Due to your posts and a few studying I’ve completed, I’ve been taking 60 – 80mg of melatonin daily. I take 60mg earlier than bedtime and take one other 20 if I get up in the course of the night time. As a result of I eat giant quantities of fluids in the course of the day this occurs sometimes.
The principle shock to me is that it didn’t trigger any daytime drowsiness. I solely get blood assessments 2 – 4 occasions a 12 months so I don’t know but if it’s going to have any impact on my biomarkers.
I believe the total potential of melatonin as a life-extension complement has but to be realized.

I simply completed up my sequence of 6 plasmapheresis therapies in 3 months as a part of the Lyfspan scientific examine, as talked about right here: Plasmapheresis Startup On the lookout for Medical Trial Members SF Bay Space

Sadly, I’m fairly conflicted about it proper now… as a result of I haven’t seen any distinction over the previous few months… if something I really feel much less nicely than I did once I was on rapamycin (I finished previous to the trial, and haven’t but began up once more). I’ll put up an extended writeup in one other thread.

So, they haven’t advised you should you had been on the placebo?

Not but – perhaps the following time I’m going in…

If it acts to cut back senescent cell load barely then the consequences will depend on your preliminary senescent cell load. CRP on the lowest degree tends to point the extent of IL-6 significantly from SASP so it offers an thought of your senescent cell load. Are you able to say what your CRP degree is?

I’ve ingested c60 in olive oil earlier than. Not the neatest factor I’ve completed, consuming buckyballs.

@John_Hemming do you may have any earlier than and after information to share in any respect concerning the impacts of this protocol?
Additionally, the place did you begin when it comes to dose and what led you to the purpose you might be at now?

@GoldenCB i’m to know your thought processes right here – what made you take into account doing this?

This has failed to copy a number of occasions since. However man, I swear I felt one thing from it haha.

@RapAdmin have your numbers modified (both good or unhealthy) because the trial?
Whenever you resume Rapa will you go straight to 6-8mgs or ease into it 1mg per week?

I don’t know but – have to get a blood take a look at subsequent week to search out out. After I relaunch rapamycin it might in all probability be one thing like a 2/4/8 mg per week ramp. After utilizing rapamycin for 3 years, I’m actually discovering how that its virtually like taking an aspirin – I don’t discover any results, regardless of the dose is. Anyplace from 2 to 28mg / week has no apparent impact that I can decide and not using a blood take a look at. I’m wondering if it is a frequent state of affairs for individuals – a form of “acclimatization” to rapamycin over time?

I’m as much as 8mg per week and in the same scenario in that I’ve seen no actual results aside from within the bloods (barely raised lipids and ALT, barely decreased WBC)….

I’ve simply booked in for Echocardiogram and CAC subsequent week. Then bloods in one other few weeks time (going to see what the addition of Acarbose has completed….been taking this for per week now).

Actually to see if there are any modifications within the Echo as I had one final 12 months (earlier than Rapa) that confirmed some slight practical declines……let’s see what 6 months of Rapa has completed!