Are SGLT2 inhibitors or acarbose higher at blocking the spike from consuming bread?

One of many TCM screening research
https://pubmed.ncbi.nlm.nih.gov/26981165/

Those that wish to go the natural path to SGLT inhibitors, see under:

• One other research confirmed that methanol extract of root of Sophora flavescens Aiton and its lively flavonoid antioxidants like Kuwarinone, Sophorafalvanone G, Kushenol Okay, and Kushenol N, inhibited SGLT2 by 99.7% in hSGLT2- COS1 cells (Sato et al., 2007)
• Moreover, Qu and his teams demonstrated that 1 mg/ml focus of ethanolic extract of Schisandra chinensis (Turcz) Baill. resulted in 89% of SGLT1 and 73% of SGLT2 inhibition in hSGLT1/2-COS-7 cells (Qu et al., 2015).

Some members appear to mix a SGLT-2 inhibitor with Acarbose – and even Metformin. What concerning the security profile of mixing totally different anti-diabetic medicine. I’d be involved about about potential infections, DKA, and so forth. So how do members mix totally different anti-diabetic medicine and is that this not a priority for these members that do?

Lol this thread got here up #2 once I looked for acarbose + bread.

I’m going to do this to make this thread helpful for as soon as. I actually did get in main bother for judging somebody for consuming bread. I have to redeem myself for that sin in order that I can cease judging individuals for consuming bread. Apart from it’s vital to persuade folks that longevity practices don’t have to contain forgoing the pleasure of meals – bread is a typical pleasure of many! (however then individuals don’t even take acarbose and that’s irrational)

FOR THE FIRST TIME IN MANY YEARS, I AM GOING TO DO THE UNTHINKABLE…

TO… ORDER… A SANDWICH…

Freezing, then thawing bread earlier than toasting, works as properly.

A physician on a special thread really posted some fascinating research exhibiting that SGLT2 inhibitors do not decrease the postprandial (i.e. post-meal) glucose spike in non-diabetics; it most likely lowers postprandial insulin however there’s no information that I do know of. Acarbose, however, completely does decrease the postprandial glucose spike (however in fact, can also trigger GI disturbance when these carbs are fermented by colon microbes).

Sure – right here it’s: (IMPORTANT) SGLT inhibitors usually are not an alternative to Acarbose

Some day, some day, I’ll FINALLY uncover that consuming bread is NOT sinning in the identical approach that carnal want or consuming increased vertebrates is.

I’d extremely encourage seeing a therapist to see in case you qualify for the prognosis of binge consuming dysfunction, ideally a cognitive-behavioral therapist or the same modality. It sounds such as you’re in search of a crutch to assist you to binge on numerous meals with out the bodily penalties moderately than deal with the underlying dysfunction. The post-binge guilt might be not less than as damaging as any hurt to your physique.

Did any of you who’re involved about blood sugar spikes after meals take a look at after having soluble fiber earlier than meals?
Consuming soluble fiber earlier than meals is meant to hinder blood sugar spikes fully I learn someplace.

I don’t have binge-eating dysfunction. Some individuals assume I’ve an consuming dysfunction, however they’re simply improper.

Sure I generally really feel guilt from consuming too many nuts or different meals, however the guilt is short-lived. It doesn’t dominate my psychological calculations as a lot as guilt from MANY MANY different sources like social messes or taking too many programs.

FWIW I don’t want bread, I’m solely testing bread only for the sake of having the ability to give higher recommendation to different individuals (and to decrease my disgust response to them). I really like utilizing the disgust response as a approach of getting everybody to sluggish their very own ageing charge as a result of I believe there’s solely good from reminding individuals to make SMALL changes in life-style in order that they’ll sluggish their ageing charge too (although I do know this makes me annoying to some events).

I’m an edgy and contrarian particular person by nature, I admit that I really like the pro-ana neighborhood (however don’t partake) merely attributable to its intrinsic edginess, I exaggerate feelings. Some individuals assume I actually have bipolar dysfunction once I don’t have it (I’m simply extra public about my sub-bipolar mood-swings than most bipolar individuals are about theirs). I like being “fascinating” and that generally means I exaggerate feelings and attempt to “pull individuals” away from being emotionally stunted, even when it generally causes awkwardness.

As a lot as I really like the CR/longevity communities, most individuals in them are super-emotionally-stunted (that’s why they’ll barely get anybody else on the earth to care about them).

Good query/level. Though I do have a level in psychology, I’m not a psychiatrist or psychologist, so I’ve reworded my above submit accordingly.

Did it. Ate 8 slices of Geneva Hostel complete wheat bread + 300mg acarbose at 6:45. It’s now 8:09. Glucose elevated from 70 and regularly peaking at 94. That is approach decrease than the glucose spike from consuming a SINGLE apple or a single lb of strawberries. AUC nonetheless stays to be decided.