Are there dietary supplements that improve Rapamycin?

In case you are not taking some other drugs that work together with GFJ (or some other drugs in any respect), there shouldn’t be any elevated liver toxicity from taking Rapamycin + GFJ, appropriate?

Proper. The priority is for one thing like a number of the statins or blood strain drugs (for instance) – you could take what you assume it your common dose, however really be getting 3 to five or extra occasions the common dose… in rapamycin its a desired final result, however not essentially with the opposite drugs.

It could be straightforward to overdose on on different drugs, whereas taking grapefruit juice, and thus typically why docs suggest avoiding it whereas taking drugs.

RapAdmin, are you conscious of any information out there associated to the time the dose multiplyer impact of GFJ lasts in our physique?. I ask this as a result of I get a compound injected three days other than my rapa 6 mg.+ 1 EVOO large gulp and I want to know if GFJ impact remains to be energetic after that 3 days interval, which is one thing I’d dislike deeply. Thanks.

I’ve learn that the dose multiplier impact of GJF may be as much as 10 hours. I like to recommend you evaluation these threads to get extra knowledge:

Right here: Rapamycin and Grapefruit Juice

Right here: The significance of “washout” time for Rapamycin dosing?

A cheap antifungal known as Ketoconazole will increase the effectiveness of rapamycin by about 5 occasions. I take 200mg two hours earlier than my rapamycin dose.

Primarily based on my understanding:

Ketoconazole might trigger liver toxicity. In the event you go this route, please monitor your liver. However it does enhance absorption by about 5X.

Grapefruit juice has an optimum enhancement interval of 1-4 hours after consumption and a multiplicative impact of 3X. Decrease enhancement multiples could also be obtained at durations of 5-10 hours after consumption. It ought to have a negligible impact after 10 hours.

Ingesting Rapamycin with a fats supply will enhance the absorption by 30%

Oh my God, I’ve simply bought the purpose throughout that I’ve the opposite compound through injection, not orally. So no interplay doable with my rapa’s GFJ. I’m again blissful once more.

And so as to add to the occasion, the compound I inject doesn’t present up within the listing of medicine with which GFJ interacts. In fact sirolimus is in it as immunosuppressant.

These are nice replies, however to make clear, I’m probably not on the lookout for dietary supplements to extend the bioavailability of Rap, I take advantage of GFJ and that works nice for me… relatively, as soon as Rap inhibits mTOR1 are there substances that improve the autophagy and lysosome exercise the place all the advantages are taking place… its appears that Quercetin and Vitamin K2 may improve the calcium channel exercise these different processes make the most of. I’ve been taking K2 together with the D3 as they’re synergistic, however simply began taking the Quercetin now… see what occurs

Simply noticed this one as nicely: