Sufferers develop a variety of signs early on within the illness course together with massive quantity diarrhea and belly ache, lack of style and odor, lack of urge for food, weight reduction and weak spot. Diarrhea and misplaced of style are sometimes the primary signs.
That is adopted by the “dermatologic triad” of nail adjustments (even lack of nails), hair loss and pigmentation adjustments on palms, soles, chest, and face. Hair loss may be speedy and mimic alopecia totalis. In some sufferers, these adjustments occur earlier than the diarrhea however often occurs weeks to months after the diarrhea and belly ache began.
Many really feel unwell with nausea and vomiting and don’t want to eat. Fluid retention is frequent.
Some sufferers have neurological points like numbness and tingling.
Polyps are discovered within the colon, abdomen and small bowel. The pathology of the polyps is that of non cancerous hamartomas. Colon most cancers develops in about 10 % of sufferers.
Many sufferers develop autoimmune issues.
Remedy is with steroids, immunosuppressants (like azathioprine) and immune modulators (TNF inhibitors) and good consideration to diet and balancing electrolytes. Mortality can nonetheless be fairly excessive and plenty of sufferers die of malignancy, portal vein thrombosis, an infection or kidney illness.
Abstract
Cronkhite- Canada Syndrome (CCS) is usually misdiagnosed or severely delayed in its analysis. We must be conscious fo the affected person who goes from wholesome to instantly feeling unwell, not eager to eat and having continual massive quantity diarrhea adopted by the “dermatologic” triad of hair loss, nail adjustments and pigmentation adjustments. This can be an indication of CCS.
