Brainstorming assist for a virus

Such physique response is most certainly from overdosing on Rapa. In the event you had edema in your legs, kidney panel blood work can be one thing that it’s essential to do to ensure there’s no kidneys injury.

Thanks for the fast response and the heads up – I’ll decelerate on the Rapa for positive. No edema in my legs, simply the feeling of swelling final evening which has handed. In actuality my toes look advantageous.

Simply as some extent of comparability – @LaraPo above takes 1mg/day (no EVOO or GJF) for stopping organ transplant rejection… you’re taking about 35 to 50 occasions greater a dose than she is… not a great factor!

Okay simply to verify, for 1 week solely I’ve thus far taken 10mg in whole. The final dose was three days earlier than I felt unwell. So GFJ and EVOO make that a lot of a distinction?

EVOO (or different kind of “excessive fats ” meal can increase bioavailability by 30%), then the grapefruit juice can do a further a number of of 350% to 700%… ontop of the 30%.

So – your 10mg in per week may equal 13mg X 3.5times, or 13mg occasions 7X, so you might be dosing anyplace between 45mg to 91mg… which might be a document excessive for this discussion board I feel (particularly for a lady, and who could also be a lot decrease weight than the typical man).

@agetron will get about 7X increase from grapefruit juice, however its extremely particular person, and sort of grapefruit juice, dependent… see right here: Rapamycin and Grapefruit Juice – #46 by Agetron

Additionally – please learn up right here: Enhance Bioavailability of Rapamycin (2)

Your immune system may very well be compromised proper now – we don’t understand how lengthy it takes excessive dosing to trigger this precisely, however watch out this subsequent week, keep away from crowds, and many others…

Of us – don’t do this at house. We don’t need anybody getting harm!

Additionally – maybe one thing you need to learn and contemplate: What To not Do When You are Immunocompromised

Actually to not freak anybody out, however one thing to think about when determining a goal to your peak serum ranges: most grownup people have a complete record of latent viral infections which are typically no drawback so long as your immune system is in working order. There are specific latent viral infections which are particularly activated by rapamycin at sure peak serum ranges. I think about that is in all probability not an excellent widespread factor to happen in weekly rapa doses resembling what most individuals listed here are doing, however it might be a purpose to keep away from the sensation that “extra is best” and making an attempt megadoses of rapa. We’re searching for a candy spot the place mtorc1 is suppresed however not mtorc2

Thanks for everybody’s concern, I’m feeling a lot better at this time however will likely be cautious. What a priceless useful resource this discussion board is, I respect your recommendation and steerage.

I’ve simply added a brand new warning to the positioning, as I’m involved that you simply and different folks may very well be leaping into extraordinarily excessive doses of rapamycin by accident, with probably very adverse well being penalties.

“BUT, rapamycin is a severe drug that may have severe issues, relying on how its dosed and different elements. This isn’t a risk-free drug. In case you are contemplating utilizing rapamycin be SURE to spend just a few months studying all of the literature on it so you may make an knowledgeable determination, ideally working in live performance together with your physician. Don’t simply rush into taking rapamycin since you heard one podcast point out it.”

has been added to this web page, and the FAQ: New to Rapamycin? Begin Right here

@Rapa4mecfs : Do you’ve a hyperlink to the Dr Inexperienced’s Lyme steerage? I’ve not seen it. Earlier than I obtained sick (late 2018), I used to be a world traveler, spending a lot of time open air mountain climbing, and many others. I took an IGeneX Tick Born Sickness check in early 2000. I used to be constructive for 3 totally different sorts of Lyme (together with West Coast, East Coast, and European sorts) and Borreliosis and adverse for the remainder of the tick diseases they check for. I did ~4-5 months of Lyme therapy (through a Lyme literate Dr.) and didn’t enhance, so we moved on to different issues (nonetheless not improved – however fortunately not getting worse).

[edited to make clear I was responding to @Rapa4mecfs who mentioned Dr. Green and Lyme not @rapadmin]

No – I’m not acquainted with it and might’t see something on his web site – are you able to please publish a hyperlink?

Simply so you already know I’ve executed months of analysis and my physician had prompt 6mg weekly.

The confusion was the point out bi and tri weekly dosing posts and discuss of the half life in people being the equal of two days compared with the mouse research.

Contemplating this info, and the truth that I’m in glorious well being and likewise very match and powerful, including an additional two 2mg doses by the week didn’t appear that excessive to me.

I hope this helps. I do know that dosing will not be settled science and am completely okay that I might need discovered what can occur if I take an excessive amount of

I prefer it that individuals are not frightened of trial and error right here, the extent of complexity on this subject signifies that solely a sure group of individuals are going to self-select to be right here.

Contemplating this I hope I haven’t prompted any lasting concern past maybe clarifying the that means of bi and tri weekly within the dosing posts.

I hope you don’t really feel it’s essential to dummy proof this discussion board on my account

I’m not criticizing you. My concern is that should you did all the things “proper” (and I feel you probably did… you researched, labored with physician and many others) and nonetheless stumbled into taking a dose that may very well be 10 occasions greater than organ transplant sufferers take – I’m involved that many people who find themselves not practically as engaged and considerate as you might simply make the identical mistake… with worse outcomes…

Are you able to consider something we’d do to assist forestall a lot of these errors sooner or later… do we have to summarize some key info in additional locations, and many others., extra warnings, and many others. so folks don’t miss it? Different concepts? Please, anybody, I’m open to options and concepts. We don’t need anybody to by accident harm themselves on rapamycin.