Such physique response is most probably from overdosing on Rapa. In case you had edema in your legs, kidney panel blood work can be one thing that that you must do to verify there’s no kidneys harm.
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Thanks for the fast response and the heads up – I’ll decelerate on the Rapa for certain. No edema in my legs, simply the feeling of swelling final evening which has handed. In actuality my ft look effective.
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Simply as some extent of comparability – @LaraPo above takes 1mg/day (no EVOO or GJF) for stopping organ transplant rejection… you’re taking about 35 to 50 instances increased a dose than she is… not a great factor!
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Okay simply to substantiate, for 1 week solely I’ve up to now taken 10mg in whole. The final dose was three days earlier than I felt unwell. So GFJ and EVOO make that a lot of a distinction?
EVOO (or different kind of “excessive fats ” meal can enhance bioavailability by 30%), then the grapefruit juice can do an extra a number of of 350% to 700%… overtop the 30%.
So – your 10mg in every week might equal 13mg X 3.5times, or 13mg instances 7X, so you might be dosing wherever between 45mg to 91mg… which might be a document excessive for this discussion board I believe (particularly for a lady, and who could also be a lot decrease weight than the typical man).
@agetron will get about 7X enhance from grapefruit juice, however its extremely particular person, and kind of grapefruit juice, dependent… see right here: Rapamycin and Grapefruit Juice – #46 by Agetron
Additionally – please learn up right here: Enhance Bioavailability of Rapamycin (2)
Your immune system may very well be compromised proper now – we don’t understand how lengthy it takes excessive dosing to trigger this precisely, however watch out this subsequent week, keep away from crowds, and many others…
People – don’t do this at house. We don’t need anybody getting damage!
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Additionally – maybe one thing it is best to learn and take into account: What To not Do When You are Immunocompromised
Actually to not freak anybody out, however one thing to contemplate when determining a goal to your peak serum ranges: most grownup people have an entire listing of latent viral infections which might be usually no downside so long as your immune system is in working order. There are particular latent viral infections which might be particularly activated by rapamycin at sure peak serum ranges. I think about that is most likely not an excellent widespread factor to happen in weekly rapa doses akin to what most individuals listed below are doing, however it could be a purpose to keep away from the sensation that “extra is healthier” and trying megadoses of rapa. We’re on the lookout for a candy spot the place mtorc1 is suppresed however not mtorc2
