obtained 4th report from 48 hours after 4.3 and all the way down to 1.7, implied half-life of 36 hours from that beginning degree. Is smart and according to chart posted above (or different thread?) that half-life longer from decrease beginning worth.
I’m a bit of unclear what the perfect values for Tmax and trough degree earlier than subsequent dose I ought to be aiming for. I’ll need to dig round on this thread and right here to analyze. I prob noticed some hints that didn’t sink in earlier than I began my testing.
Or I suppose I can ask Dr. Inexperienced.
Oh, I forgot to say, I additionally take CBD and Theracumin(Curcumin), and iirc the previous ought to inhibit Rapa metabolization and the latter appears to extend it and vastly decrease AUC: Turmeric Linked to Liver Harm, Lower in Rapamycin Bioavailability. (Although confusingly I’ve seen it each methods, that Curcumin each inhibits and prompts the related CYP pathway. I’ll put up within the thread about that…)
[side note on CBD. I took it to help sleep, but it cured my Morton’s Neuroma (nerve pain in foot) immediately! I’d had annoying pain in the morning literally every single day for over a year, and a Dr rec’d CDB for sleep, so I gave it a try, and the next morning after being awake for a while I realized that my foot hadn’t hurt at all. So I’ve been taking it every since and the pain hasn’t returned. And it can’t be placebo, because I took it for sleep and it never occurred to me it would help with foot pain…]
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Sure – you ought to be a bit of unclear… no one actually is aware of for certain. On the Tmax degree, within the NIA ITP mouse research, typically the upper the dose, the higher the lifespan improve. In a single research ( of the 45+ research of rapamycin in mice) they did lastly discover an higher dose of rapamycin that not elevated lifespan in these feminine mice. It was an especially excessive dose although.
On trough ranges, individuals appear to focus on underneath 1ng/ML per right here: Easy methods to get a Rapamycin (sirolimus) Blood Stage Check however once more, we don’t have absolute numbers right here.
I ought to observe that in mice there’s a important dose / response distinction between male mice and feminine mice. This distinction is just not seen in people.
Most of individuals at present utilizing rapamycin appear to be (in mouse equal dosing) within the low ranges examined (observe: mice had been dosed rapamycin of their meals, each day, so that’s one other distinction – vs. us utilizing rapamycin dosed as soon as weekly or so).
Listed here are the Nationwide Institutes on Getting old Outcomes from their rapamycin research (these are the most effective rapamycin research):
| Sirolimus Dose |
mg/kg/day Dose |
Blood/Sirolimus Stage |
Male Median LS Enhance | Feminine Median LS Enhance |
|---|---|---|---|---|
| 4.7ppm | ∼2.24 | 3 to 4 ng/mL | 3% | 16% |
| 14ppm | ~6.67 | 9-16 ng/mL | 13% | 21% |
| 42ppm | ~20 | 23-80 ng/mL | 23% | 26% |
Listed here are outcomes from all the upper dose research I might discover:
| Sirolimus Dose |
Mouse mg/kg/day Dose |
Mouse: Blood/Sirolimus Stage |
Human mg/kg/day Dose |
Dose for 60kg Human | Day by day Dose adjusted for longer half-life (/4) |
|---|---|---|---|---|---|
| 4.7ppm | ∼2.24 | 3 to 4 ng/mL | 0.182 mg/kg | 10.92 mg | 2.73 mg |
| 14ppm | ~6.67 | 9-16 ng/mL | 0.542 mg/kg | 32.54 mg | 8.135 mg |
| 42ppm | ~20 | 23-80 ng/mL | 1.626 mg/kg | 97.56 mg | 24.39 mg |
| 126ppm | ~60 | 4.878 mg/kg | 292.68 mg | 73.17 mg | |
| 378ppm | ~180 | 45 to 1800 ng/mL | 14.634 mg/kg | 878.04 mg | 218 mg |
Based mostly on the FDA animal to human dosing conversion information right here.
Notice: ½ life for sirolimus in mice is approx. 15 hours, vs. approx. 62 hours in people. So, mice metabolize sirolimus roughly 4 instances sooner than people.
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Unbelievable, thanks!
You simply saved me numerous hours I had meant to spend to gather and convert (after determining how one can convert) that knowledge!
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Thats what the location is for… everybody shares the work they do do, and the information they collect, so that everybody doesn’t need to do all of it themselves!
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Properly, simply obtained my outcomes again after 10mg + contemporary grapefruit juice (and I ate pulp for good measure) + swig of olive oil: solely 15.6
That’s in comparison with earlier 10 mg dose on empty abdomen which led to 11.2
Each after 90 minutes. Perhaps I would like to attend longer to check?
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I’m undecided ready longer will make a distinction I wait simply an hour and a 1/2 and get 6 to 7 instances the rise.
Everyone seems to be totally different.
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However good for you for taking the measurements.
That is the one manner that you simply’re going to understand how your physique is responding to GFJ and your dose of rapamycin.
Right here’s my end result. That is about 90 minutes after taking 2 1mg Biocon capsules along with 2 1mg Zydus capsules with half a small crimson grapefruit, 2Tbs of EVOO, washed down with a small quantity of pasteurized crimson grapefruit juice. The check end result additionally places to relaxation the notion that the Indian product is faux or ineffective.
Sirolimus (Rapamune), Blood
Check Present Outcome
Sirolimus, Blood 31.8 ng/mL Reference interval 3.0-20.0
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Is Marek Well being nonetheless providing the sirolimus check? Hyperlink didn’t work for me
If not, who has the most cost effective check?
You’re proper – doesn’t work on cellular for me, however works on PC
