Does rapamycin make your face look youthful?

Does rapamycin make your face look youthful? Thanks.

I’ve been utilizing it for a lot too little time to note any distinction. There are some research for topical rapamyicn that reveals some promise.

e.g.

Simply this morning i discovered additionally this web page

however each are for topical cream. Wouldn’t learn about systemic use. May need some impact as effectively.

Thanks. However while you say you’ve been taking it for a lot too little time … how lengthy have you ever been taking it? Thanks

I’m wondering the identical. I’ve solely been on rapamycin for two months however within the final couple of weeks I’ve had 4 folks assume I used to be in my 40’s. I’ve not had anybody suppose I used to be youthful than my age for a loooooong time in order that’s promising. It could simply be a coincidence in fact.

As talked about, there’s proof to recommend that topical rapamycin might help pores and skin well being.

There may be a whole lot of proof that rapamycin will sluggish the growing old on most of the physique’s organs… see this thread: Can Rapamycin restore your organs and due to this fact reverse growing old?

The pores and skin is the most important organ of the physique, and moreover there’s vital muscle and different tissue within the face. I strongly suspect, however can’t but show, that rapamycin will considerably sluggish (however maybe not reverse) many age-related adjustments to the face.

If what is occurring within the many different organs of the physique, can also be taking place within the pores and skin and muscular tissues of the face, then we must always see a lot much less sagging of pores and skin and tissue, and muscle atrophy, that’s usually seen in folks as they get age.

I’ve contacted rapamycin researchers about this, as there are presently long-term research ongoing with monkeys utilizing excessive dosing of rapamycin. It wouldn’t be very onerous to do pores and skin samples and picture evalutation of the handled monkeys vs. the management monkeys, to judge this concern. We’ll see if we will get it shifting ahead and I’ll let you recognize.

Second dose. I’ll report again in time…

Sure I agree that there is perhaps a chance that it will make pores and skin youthful, particularly by eradicating solar harm through autophagy I assume. Possibly immune activation would stimulate collagen manufacturing by fibroblasts.

i’ve been on rapamycin roughly two years and utilizing a topical rapamycin face cream for 4 months. it’s onerous to know if I look youthful nevertheless it positively feels youthful (purely anecdotal).

I’m truly cautious of attempting rapamycin in case it does stimulate collagen, as a result of I had a therapy which stimulated an excessive amount of collagen in my jaw and I would like it to go down!

There may be some analysis on the subject, however I’m not a dermatologist… and its clearly advanced.

Moreover, reducing mTOR expression by about 50% by utilizing small interfering RNA resulted in a major lower of collagen mRNA (75% COL1A1 lower and 28% COL1A2 lower) and protein ranges. Thus, mTOR performs an important position in regulating basal expression of collagen kind I gene in dermal fibroblasts.

Supply: Mammalian Goal of Rapamycin Positively Regulates Collagen Kind I Manufacturing through a Phosphatidylinositol 3-Kinase-independent Pathway – ScienceDirect

Rapamycin can inhibit fibroblast proliferation, collagen accumulation, and urethral stricture in rabbits.

Supply: Rapamycin Inhibits the Progress and Collagen Manufacturing of Fibroblasts Derived from Human Urethral Scar Tissue – PMC

Extra information: rapamycin stimulate collagen – Google Search

It’s a coincidence.

You would possibly genuinely seem like you’re in your 40’s, nevertheless it isn’t from taking rapamycin for 2 months.

Nice! Secure to attempt then. Thanks

@Phil_Van_Treuren, I used to be considering it might additionally simply be from feeling a bit higher impacting how I carry myself. Maybe by having a extra optimistic outlook and elevated hopefulness I come throughout as a bit younger to others?

Is there a threat of growing zits with topical software of rapamycin, much like the unwanted effects noticed with oral administration?”

It’s hypothesized that topical administration of rapamycin could lead to greater cutaneous absorption in comparison with oral consumption, doubtlessly resulting in extra extreme zits I wish to know if folks expertise zits as an facet impact of topical rapamycin? If the reply isn’t any, it’s curious why topical rapamycin doesn’t trigger zits like oral rapamycin.