Is there any good proof for a way a lot mTOR is supressed by every dose of Rapamycin from 1mg to 10mg?
1 Like
That’s an fascinating query, however its additionally a fancy one; the mTOR inhibition seemingly varies by cell kind, tissue, and organ, and by individual (private biology). I don’t assume now we have the reply proper now – maybe another person has seen a paper that addresses this however I can’t recall any.
A part of the problem is that whereas rapamycin has been round a very long time, and in medical use in organ transplant sufferers for over 20 years, that software and their objectives are very completely different from those in longevity functions. Their objective could be very easy, a restricted quantity of immune suppression (simply sufficient in order that the organ isn’t rejected by the physique, however nonetheless excessive sufficient to offer safety from different overseas invaders. They aim a particular steady blood stage of sirolimus on an ongoing, day by day foundation to attain that – I appear to recall 5ng/ML to fifteen ng/ML, however I could also be fallacious.
In abstract, I believe that is nonetheless an space that wants loads of analysis.
1 Like
Hello RapAdmin
Thanks very a lot certainly to your informative reply.
