Facet Results of Rapamycin (half 2)

You guys all notice this dude might be going to die from injecting random black market Chinese language prescribed drugs and can cease posting quickly, proper?

Edit: it’s been two days since he posted, he in all probability died.

Sort of a scorching mess.
Nothing so as to add to this dialogue in IMHO

On a optimistic word, the one who’s to die from poisoning won’t ever drown.

I don’t know what i put up has been posted or not so will attempt to reply a number of questions most multi function put up in all probability repeated as a result of additionally i discover my comment replies don’t get posted proper beneath the problem posted by others however manner down. As to “i’m curious as to call of my provider” it’s Mesochem which primarily sells massive portions of API’s to different corporations however they might make some exceptions and promote to people corresponding to massive portions of NMN. It could be that a few of these authorized corporations u supposedly record that the products originated from Mesochem although additionally in the event that they don’t occur to have one thing they might get it from certainly one of their associates so possibly in that case they could possibly be referred to as middlemen however solely in some circumstances. As to ” I haven’t seen a single put up from you but the place you really state any “numbers ” i’ve performed precisely that in 2 or extra prior posts. Sadly this interface doesn’t appear to print all that i put up and/or erases replies if depart them within the reply field with out put up for greater than possibly 20 hours or offers message in electronic mail ‘Supply incomplete…’ and don’t know precisely which messages they had been referring so anyway once more: How did i arrive at 20 to 30mg injection. For one from the printed mouse/rat research articles periontally(possibly spelling error) injections which confirmed probably the most spectacular outcomes at 10 to 15mg per kilogram. Utilizing the printed 12.3 issue for mice and rats in comparison with human then that interprets to round 1 mg per kg for human and i’m like round 70kg so i must be utilizing 70mg and what’s greater than that the mice/rats had been getting that day-after-day not simply each fifth day. As to the ketamine reference that has nothing to do with these feedback on rapa and is a completely completely different matter which has to do with having fun with ones self .
As to the assertion “. Now you say you haven’t purchased something random from China. So which is it??? ” The phrase random referred solely to the truth that i didn’t cope with a random firm – not ’ haven’t purchased something random from China ’ If that’s precisely the way it got here out then it was a misprint although extra doubtless your interpretation was off. And that i don’t inject ‘random medication’ . To the subsequent put up from somebody yea utilizing faucet water in PI was a mistake although all these years, like 9 or 10 whole in pi, till proper after that injection at a distinct place i by no means recall having any excessive and even very noticable diahrrea so i simply thought it was as protected as injecting faucet water in usa of which articles proclaim is okay and customary sense that it’s innocent in usa. Although i forgot to contemplate in pi it could nonetheless have had e-coli or no matter however simply not sufficient for me to note any considerable diarrhea however sufficient to trigger infections which i did get. Fascinated about blood outcomes okay solely 4 or 5 gadgets within the 2 blood exams (greater than a yr aside) had been out of regular vary – nothing excessive and solely because the articles recommend are regular deviations when on rapa . In a really abbreviated type the place ‘n’ means regular vary,
‘l’ means decrease than regular, ‘h’ means excessive, okay means inside regular vary as does omission of that class which is most of them.

Full blood rely san jose 14dec2021 blood check abnormalities: 6 outcomes out of regular vary
lymphocytes 11.8 h norm 4.8-9.4 (may be excessive resulting from an infection) ,
erythrocytes 4.1 l n 4.4-5.9,
hemoglobin 12.8 l n 13.5-17.9 ,
hematocrit 37.3 l n41-53.7,
RDW 15.8 h 11.5-15 ,
platelets 436 h n150-400

7Feb23 Cebu, philippines 7 outcomes out of regular vary
lymphocytes 21.2 okay{word completely different scale in Cebu than in san jose?} , erythrocytes no discover in cebu cbc
hemoglobin 115 g/L low norm 135-180(worse than in sj)
hematocrit .34 low n .42-.52(worse than in sj)
purple Blood CellsRe 4.19 low (in 10e12/L models) n 4.7-6
platelet rely 621 excessive (in 10e9/L models) n 150-450
monocytes 12 excessive in % n 2-11
Absolute Lymphocyte Rely 1.00 low (in 10^9/L models) n 1.50~3.50
full Ldl cholesterol 158.20 mg/dl <200 4.07 mmol/L <5.14 good. Nothing fallacious right here however even higher than common esp for 75 years previous
although this favorable outcome is because of particularly my consumption of 20mg each day of mk677 which has been confirmed greater than as soon as previously
If had not had any mk677 for a lot of months i’m pretty certain whole ldl cholesterol could be positively over 211 say

” Edit: it’s been two days since he posted, he in all probability died.” yea humorous which exhibits lots of these posters primarily are monkey see monkey do and
put up in keeping with emotion and never information.

now additionally from messages i get in electronic mail i don’t know if my solutions are getting posted i’ll put up once more to a previous query:
Anyway to reply the query i take only a few what could also be referred to as medicines or eating regimen dietary supplements i take apart from rapamycin with ketoconazole and issues corresponding to nutritional vitamins and topical tacrolimus it’s often each day : selegiline 5mg , mk677 20mg , nmn 1gram, Pterostilbene like 200mg, resveratrol on and off of various quantities , diphenhydramine for sinuses as i really feel wanted however often involves round 50 to 150mg each day and periodically pregnenolone and/or much less steadily dhea and dmae and generally creatine and sadly most of the time zopiclone 7mg for sleep which i would love to get off , cease.

Thanks for sharing your expertise. It’s informative to see the unwanted side effects of a really excessive dose rapamycin routine. A few of these results you had been in a position to observe, some solely present up on the lab studies.

Right here is how I’d estimate your efficient rapa dose. Oral ketoconazole inhibits CYP3A4 in each the liver and the gut. The impact of ketoconazole on oral rapamycin is about 5.5 fold enhance. Because the intestinal share of the enzyme is contributing solely an estimated 20% of that impact, the remaining coming primarily from enzymes within the liver, I’m guessing that you’re getting a 4 fold enhance in efficient dosage. Though the precise quantity cant be decided since there are large particular person variations, I’m estimating your efficient dose is about 4x20mg or 80 mg. Moreover, since you might be dosing each 5 days and it takes 2 ½ weeks to clear the earlier rapa dose out of your system I’d examine your dosage to a 90mg dose.

It will be helpful to match neutrophils (% and absolute) and lymphocytes (% and absolute) earlier than and after with a purpose to relate despair of the immune system to the unwanted side effects. Additionally, when you’ve got different earlier than and after information, e.g. your WBC, excessive sensitivity CRP please put up.

A excessive RDW outcome may also be an indication of different situations, corresponding to:

I do assume excessive dosing of rapamycin has a unfavourable impact on RDW and iron ranges.

I’ve given blood twice yearly previously, however apparently my donations in 2022 had been too shut collectively coupled with my comparatively excessive rapamycin dosing and after 6 months since my final donation they haven’t returned to regular.

Sadly my ferritin ranges had been solely examined by the Crimson Cross till lately. They all the time claimed that my ferritin ranges had been okay on the time of the donations.

My most up-to-date two ferritin exams taken about 4 weeks aside indicated a beneath regular studying of 6 ng/mL. Both one thing else has modified or my dosing of rapamycin is just too excessive.

My inclination proper now could be to assume that my rapamycin dosing is just too excessive. I’m presently not taking rapamycin till my ferritin stage returns to regular. I’m additionally now taking an iron complement.

Rdw must be thought-about with the latest mcv historical past

While your mcv is bettering rdw will deteriorate. At a gradual state rdw will enhance.

Undecided if I ought to put up right here or in its personal thread however I assumed I’d report on my first week of utilizing rapamycin, I used 4mg (no grapefruit juice or something) and solely weigh 115lbs. On reflection this was both too excessive a dose to begin or rapamycin simply will not be a good suggestion with my situation.

Background-> mid 20s male, affected by persistent well being points since covid vaccination 2 years in the past in april/2021. Please don’t press me on this, sure I’m sure. Inside 48hrs I developed coronary heart points (PACs, very heavy coronary heart beat (resolved) tachycardia (semi-resolved) in addition to irritation primarily in my sternum/chest that will unfold to extra areas over the course of the subsequent two years. I even have speedy muscle twitching that’s fairly random throughout however I’m not tremendous bothered by it. I nonetheless have PACs very commonly so going into this rapamycin dosing it was principally that situation, joint and muscle ache/irritation, (a lot of crepitus in my joints presently, impacts my higher backbone, shoulders, ribs/sternum. Limbs are typically not affected) and lymph node ache that I hoped to see optimistic adjustments in. Lymph node ache and burning muscle/joint ache exist however are stored principally manageable with medicine. These points are day-after-day and don’t come and go. I don’t perceive the true nature of my situation to today sadly.

For the start of my rapamycin trial I used to be not taking my regular medicine (it helps however isn’t miraculous, simply really feel quantity worse off of it however have had occasions the place I couldn’t get it for a couple of days together with lately so I do know what it’s like)

First day of taking rapamycin I don’t recall having points, nevertheless on the second day after I began having somewhat critical muscle ache, joint ache, lymph node ache in my left neck primarily and burning ache within the often areas. Joints that aren’t even usually affected corresponding to my elbows additionally had been very achey and I didn’t need to transfer round a lot. I caved and went again on my regular drugs which helped quite a bit, however didn’t absolutely reverse the problems. Over the subsequent few days again on my drugs my joints had been nonetheless extra achey than regular, and if I had been to explain the ache it will be one thing like chilly burning aching ache which doesn’t make lots of sense I suppose… Moreover I skilled some taking pictures pains that I’m uncertain are nerve or joint pains in my toe knuckles or arms and a pair different locations. No digestive points, or sleeping adjustments. Mouth sores, possibly very slight the place it hit as I took the capsules and slight reflux only for a day, and possibly slight irritation alongside my esophagus in consequence, nothing too bothersome there.

It’s been 6 days now and I’d say my joints are a bit worse off than once I began and have been extra achey simply. I plan to attend a couple of extra days earlier than contemplating retrying from 1mg, at this level there’s in all probability about 1mg nonetheless in my system and it’s tolerable however I’m not certain it will likely be useful for me. Very unlucky as a result of I’m operating out of fine concepts for the right way to handle these signs, I’m trying towards HBOT sooner or later when I’ve a greater monetary scenario.

I’m not certain if this might assist, however I took my first dose (1mg) a month in the past and since have taken two extra dosed (2mg and 3mg) every week aside and I need to say that my first dose produced most disagreeable signs that ranged from feeling fidgety, elevated RHB, actually drained and had joint and muscle ache, like getting a viral an infection, even after 5 days I had actually sore throat and a canker sore began to develop on the tip of my tongue. Since that dose I had virtually none perceptible variations besides I really feel this combination of drained and energized for 2 – three days put up taking rapamycin. I additionally observed that my joint ache and muscle pains that had been borderline “fibromyalgic” are much less perceptible (could possibly be placebo, I need to take rapamycin for longer to make any claims on this course). I do have this random pains since I used to be a baby and gotten a thick an infection.
About put up covid vaccination troubles, I can’t say something on the matter. I used to be vaccinated 4 occasions (mRna vaccine / twice Pfizer, twice Moderna) and had no points. Contracted covid that was picked up by check, however had no signs what so ever. I imagine LPCVS generally is a nuisance or extra and I hope you will see that one thing that can assist. I personally dwell with this “fibromyalgic” ache since childhood, I bear in mind the precise day it began, however managed to dwell regular life, didn’t make it a difficulty. Had all of the exams performed in my teenagers, every part got here again regular or inside regular values and possibly acceptance that one thing is completely different and that you simply earlier than that doesn’t exist any extra could be part of your journey.

Thanks for the response, I’ll take that into consideration. I believe total I do have robust emotions of desirous to proceed however sure I actually should take it gradual from right here which might be what I ought to have performed from the start.

Listed below are my experiences from 4 mg Rapamycin + grapefruit Juice and a doubtlessly contributing impact of apigenin.

The night earlier than 4 mg Rapamune, I had one half of a purple grapefruit.
Two hours and quarter-hour earlier than Rapamune I had the opposite half of the purple grapefruit and 225 ml purple grapefruit juice.
quarter-hour earlier than Rapamune I had a fatty breakfast. A two egg omelet, french fermented cheese and a few oil.

After 4 mg I had three days of diarrhea and a foul higher abdomen discomfort in abdomen, jejunum, gallbladder and occasional refluxes (which is one thing I by no means have). I skilled an aching sensation when meals was on its manner by (what I understand as) the decrease esophageal sphincter and the meals was about to enter the abdomen. The diarrhea vanished after three days. However the discomfort continued for an additional 3 days.

First, I assumed the large response was solely due to the grape juice. However then I stumbled upon the references to parsley and apigenin. It struck me that I additionally had taken 400 – 500 mg powdered apigenin within the evenings the week earlier than Rapmune, the goal was to enhance my sleep.

Be aware worthy is the truth that the week earlier than, I had additionally taken amla powder to get nutraceutical help towards rapamycin’s doubtlessly undesirable affect on blood sugar metabolism. And I additionally had additionally had 1-2 teaspons of lions mane powder each day. So in addition to apigenin, there could be two different contributing components.

This was the primary time I attempted to enhance bioavailability.

My predominant principle is that apigenin would possibly amplify the impact of grapefruit. And it will be actually attention-grabbing to see a case examine of apigenin and Rapmycin. If it enhance absorption? Then it will be an alternate that’s simply standardized and which have fairly a little bit of different well being selling results.

For many who have an interest, that is my exp with Rapamycin 2mg/week which led to (comparatively) rapid unwanted side effects after approx 3 weeks of use, which included slight swelling/oedema on my left cheek. I had a discussion board put up on this and primarily based on pathology and Dr Inexperienced enter, pretty sure Rapa is in charge.

How lengthy did it take for the swelling to go away? I’ve the identical drawback and have stopped the Rapa for a month now, however swelling remains to be there.

Sure… it was a gradual return to regular… about 2 months…however I used to be on a dose of 38 ng/mL for 7 months.

As I acknowledged, I assumed it was the minoxidil inflicting the edema… from one thing I examine dosing with minoxidil… that at 3 months…the edema resolved within the medical trial sufferers… I didn’t assume it was the rapamycin.

However I decreased the rapamycin to 12 ng/mL… and stored the minoxidil on the similar dose 5mg per day.

In the present day my legs and ankles are skinny and muscle mass outlined once more.

Thanks for response.
I’m going to remain off the Rapa for an additional month or until swelling goes away.

My ankles swelling lasted 48 hours after taking 5 mg of sirolimus with EVOO and grapefruit juice. It occurred two occasions in a row. After I decreased the dose to 4 mg the edema didn’t seem any extra.

Sure! As Blagosklonny says… up the rapamycin dose till you get aspect efforts… edema… swollen ankles is a aspect impact.

Time to scale back the dose. I lower my dose to 1/3.
12 ng/mL… no extra issues.