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Facet Results of Rapamycin (half 2)

Hi there! First submit.

Uncomfortable side effects–do they have a tendency to ease over time, at weekly (1mg) doses? Mine weren’t delicate.

60yo feminine. I usually have atypical reactions to Rx and dietary supplements, together with reacting to low doses, having quick responses, and being slow-metabolizing.

Yesterday took first dose rapamycin (1mg sirolimus) with meals (however maybe not sufficient?). Noticeable reactions, first ~half-hour: head strain, abdomen discomfort (bordering on nausea), brainfog, sense of being off, delicate light-headedness. (In contrast to reactions I’ve needed to any med or supp. I don’t have filler allergic reactions, so I’m assured that that is the rapamycin I’m reacting to.)

Signs eased at half-hour, however continued the remainder of the day, ~13 hours. (sigh.) Woke at this time feeling largely higher. (yay!)

I’ve learn many posts right here, and it appears my responses are, unsurprisingly, atypical. :smile:

Query: do individuals alter to side-effects like mine at weekly doses? How lengthy does it are likely to take?

I don’t plan to go up any time quickly. I would even go down, if this isn’t one thing that I alter to.

Thanks on your ideas!

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Based mostly on the timeline I think it’s simply noceabo signs

The signs you point out are very uncommon. The truth that they appeared to largely subside fairly rapidly is an efficient signal. So long as the unwanted side effects aren’t debilitating I’d proceed on the present dose every week and see how issues progress. I had one mouth sore at month 3 or so, and have by no means had one other canker sore. So, sure, some unwanted side effects occur as soon as and by no means once more. Some are periodic, and generally extra incessantly recurring. its onerous to foretell upfront what your course shall be.


After I began I had not learn a lot and didn’t learn about this group and I feel Dr Inexperienced mentioned to take between 2 and 6 mg each 1 to three weeks, so I began taking 4 each 2 weeks. So I simply began taking 4.

By no means observed a lot, however did get cramps (when working) that I hadn’t had since highschool. Actually I’ve by no means had any of the signs you described. I did it with meals, on empty abdomen, nonetheless nothing. Grapefruit Juice undoubtedly multiplies the dose by about 4, so that may get monetary savings later.

If I had been you I’d simply blunder on and do it once more. See if the signs are there once more. That may be good science. It may have been one thing else.


Thanks. It’s useful to know that some signs come and go.

I particularly welcome listening to from anybody who has had related signs.

Sure, @RapAdmin I do know my signs are uncommon. I’ve spent a few years being the minority report. :smiley: It’s an enormous PITA to have atypical reactions, and it’s made me way more cautious and deliberate in what I report and the way.

I used to be educated within the sciences. I get how inconvenient outlier outcomes will be. Whereas it’s tempting to low cost odd outcomes, it’s not good science; if we solely search for what we anticipate, that’s all we’ll see.

Thanks for the sound recommendation.


Happily, the signs relating to Rapamycin sometimes abate when dosing stops (and after a few week of washout). Good luck in your Rapamycin journey!


These unwanted side effects don’t sound so bizarre, much like mine my first couple of doses (I began with 2mg on an empty abdomen) however now I hardly discover something from 12mg with grapefruit juice (efficient dose of 36-40mg)


Thanks. Good to listen to from somebody with related outcomes. Was the 2nd dose higher than the primary? Did you discover that meals/juice/something diminished the side-effects?

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DeStrider, Please present a model title on your isoconazole. I can’ appear to seek out it.

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sol, You say you took 1 mg sirolimus with meals. What model sirolimus and what meals did you utilize? Was this a daily meal that you simply usually have each day or was the meals one thing like grapefruit juice, olive oil, and many others. that you simply don’t usually eat frequently?

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The bottle reads: MFR: Glenmark Pharm. Packaging is generic Rx distributed by Amazon. Capsules seem to have enteric coating. Consumed with a little bit of my regular meals, together with espresso with cream, 1g OM3F, and later chased with some yogurt–all typical for me. Nothing like grapefruit or OO.


I exploit Travogen. There may be additionally Travocort with a corticosteroid.

Right here’s an inventory of all of the drug names for isoconazole

Arhu, how usually do you dose?

sol, Because it’s your regular meals, espresso, and yogurt I’ve no strategies about your a lot higher than regular unwanted side effects. However, I do counsel that you simply don’t go above 1 mg weekly till you not expertise any unusually unhealthy unwanted side effects.

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Thanks. That matches my plans. :smiley:

I’m completely satisfied to say I’m additionally noticing some marvelous up-side results, as properly. To date, I’m undoubtedly happy with the outcomes.



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