Ladies Taking Rapamycin for Enhanced Fertility / Menopause Prevention? – longevity

A publish from one other thread right this moment:

I’m 64 in menopause for 7? Years the Rapamycin appears to be reversing menopause, I’ve been having scorching flashes temper swings and recognizing! (supply: this publish )

I’d be curious if she’s taking HRT. These signs could possibly be because of excessive estrogen (recognizing) or low estrogen (scorching flashes). My understanding is that some follicles exist till about ten years after menopause however after that I’m unsure the way you’d “reverse” it. It might be fascinating to get her hormone ranges checked!

Would you thoughts sharing which hormone checks precisely? I’m 7-8 years publish menopause and after being on rapamycin only one month I’m having some fascinating adjustments already. I’d like to start out monitoring my hormones. Thanks

No I’m not take HRT or any hormones!

Oh thanks for responding! And for sharing your story! If you happen to get your hormones checked (estradiol, testosterone, progesterone, FSH, LH) I’d like to see the place they arrive again, particularly when you have any labs from the previous few years once you had been menopausal however not taking Rapa.

I often prefer to see estradiol, testosterone, progesterone, DHEA if menopausal and taking hormones. FSH and LH are good to have as effectively. And, after all, when you occur to have earlier labs then that’s useful for comparability.

Thanks a lot. I’ll get these checked and publish my outcomes. @AmyK

Hello Amy, a query from a guys perspective. Are there any checks that you simply suppose is likely to be applicable for guys taking 17-alpha estradiol to validate that in impact its moving into the physique?

Individuals are beginning to strive it: 17-Alpha Estradiol – One other High Anti-Getting old Drug

And because you’re clearly up on the entire hormone testing problem – I used to be questioning when you’ve ever carried out hormone testing on males (apart from TrT sort purposes)?

Hey. Sure! I’ve not examined particularly for 17-a estradiol however have positively examined for normal estradiol in addition to testosterone, FSH, LH, DHT, DHEA, and so on. It is likely to be useful to examine inflammatory markers like CRP in somebody taking 17a Estradiol since there’s some animal proof that irritation goes down.

I began rapa over a yr in the past…. I began at 1 mg as soon as per week, however have labored my means as much as 5mg as soon as per week now.

Earlier than rapa, I used to be experiencing periomenopause signs…. Lighter durations that got here as soon as each 2 – 3 months or so… I believe… I wasn’t actually holding monitor….

Now I didn’t begin taking rapa for fertility…. I by no means even learn something about rapa having an impression on extending fertility…. I simply wished it for longevity….

I’ve began noticing once I acquired to my greater dose (5mg) that my durations have returned as soon as a month…. And they’re now not mild as effectively…. Btw- I’m 48 now….

I’m glad to see this publish, as a result of to be trustworthy, I used to be getting frightened…

@AmyK good to see you right here additionally !

Do you comply with a sure stack and timing with dietary supplements and medicines? Dr. Mindi Pelz recommends to quick solely within the 1st half of a cycle. Now this is able to translate into taking rapamycin and sure polyphenols solely within the 1st half.

My private stack seems to be as follows: The day I take rapamycin, I’ll quick and I’ll take fisetin, resveratrol, spermidine and quercetin. Generally I exploit at the present time as a place to begin for an extended quick of 4 days in a row. If I don’t quick, I’ll at the very least hold my protein and sugar consumption low.

After 4 days of taking rapamycin I ramp up my protein consumption, complement with collagen and as soon as a month do a microneedling session throughout refeeding.

Now, do I’ve to concentrate to my cycle and never take rapa within the 2nd half?

Many because of all of you, this discussion board actually helps!

I believe your plan is smart. I don’t quick (I’m already skinny and don’t wish to lose muscle) however I do plan my harder/heavier weight coaching on the second half of the week if doable (furthest from my Sunday Rapa dose).

Why do you begin your quick once you take Rapa? Rapa mimics hunger. If you happen to quick along with taking Rapa, it’s like double quick.

Lara, there does appear to be some overlap in what rapamycin and fasting does, however there additionally appears to be vital variations. For instance in muscle:

Distinct and additive results of calorie restriction and rapamycin in ageing skeletal muscle

https://www.nature.com/articles/s41467-022-29714-6

So, its not unreasonable to do each.

Extra of a dialogue right here: How Rapamycin Extends Lifespan (mechanism and implications) Dialogue