Make your arguments for Rapamycin dosed As soon as Weekly vs. As soon as Each Two Weeks – longevity

@brandy111 Good level! Sirolimus absorption has been a bother spot and why compounding variations can have situation vs. commercially obtainable.

Dr. Mannick’s pod forged introduced up many good factors together with the remark about mTOR modulation and the way it adjustments with growing old – youthful individuals flip off mTOR after they quick (assuming she is speaking about after they sleep) and older individuals don’t do that modulation as a lot. Taking your mTOR blocker of alternative at evening when it has a peak could make sense?

Making an attempt to imitate the mTOR modulation of the younger is one method, however it seems that periodic blocking of mTOR of youthful (mice) could have even a greater impact on longevity. This may occasionally create a query of making an attempt mimic youthful mTOR modulation vs. Supraphysiologic (extra blocking than is often seen than simply by being younger).

Observationally, it appears a lot of the consultants that strive the each 2 week (excessive) dosing, return to the weekly dosing – Attia, Inexperienced, Dr. B.

After having tried completely different doses from 1 – 6 mg +GFJ (4-6 mg was each two weeks), I feel my candy spot is 3 mg + GFJ weekly. I could strive a better dose now and again. Thanks for all of the dialogue and data.

Hey Chris… you’ve come to the place I’ve… 2mg and GFJ…I needs to be getting a 12 mg dose based mostly on my GFJ response. Appears to be working nicely… after months of 36 mg… the place I felt wonky…the whole lot appears fairly good throughout the board now… muscular tissues, exercises, weight upkeep psychological alertness. I’ll do a brand new blood panel in a number of weeks… and put up it. Assume 2mg and GFJ is my candy spot… additionally I do steady rapamycin…no breaks.

This video is now non-public. Do you or does anybody know of it being obtainable elsewhere? Is it presumably the identical as this part of a bigger interview?

That’s not fairly correct. First, the weekly mouse research postdated Mannick’s human trials.

Second, Mannick’s first trial, they tried 0.5 mg everolimus every day, 5 mg weekly, 20 mg weekly. 5 mg weekly was as efficient because the others with fewer side-effects.

Within the Section 2A, they used 0.5 mg of everolimus every day, 0.1 mg of everolimus every day, 10 mg of the catalytic inhibitor RTB101 (beforehand often known as BEZ235) every day, or a mixture of 0.1 mg of everolimus and 10 mg of RTB101 every day. Based mostly on the first final result (vaccine response), solely the mix succeeded; in case you spelunk round within the paper, I feel you may make the case that each one the everolimus-containing protocols had some impact.

Within the Section 2B, they used RTB101 5 mg every day or RTB101 10 mg every day partially 1 and RTB101 10 mg every day, RTB101 10 mg twice every day, or RTB101 10 mg plus everolimus every day.

In Section 3, they used RTB101.

Once more pointing to the truth that extra will not be higher. The max dosage with out undesirable unwanted side effects as as soon as postulated by Dr.Blagosklonny is lifeless so far as I’m involved.

[desertshores]

[ desertshores]
Once more pointing to the truth that extra will not be higher. The max dosage with out undesirable unwanted side effects as as soon as postulated by Dr.Blagosklonny is lifeless so far as I’m involved.

Effectively, besides that within the rodent longevity research, it’s very clear that the upper the dose the higher — and in almost all of these, the animals get their rapa a number of instances a day, on daily basis, of their meals. I feel it’s a severe query whether or not anybody taking 5-10 mg rapa or everolimus weekly is getting an efficient anti-aging dose.

Sure, I’m nicely conscious of the extra is best idea. This can be true for rats, mice, fruit flies, and many others, however in fact everyone is aware of that these research don’t all the time translate to people.

People have extra genes in frequent with cats and canine, than rats and mice.

My very own blood work over the course of ~15 months signifies that the excessive doses I’ve been taking are in all probability detrimental or no less than not optimum. Many different discussion board members have reported worsening blood take a look at numbers resembling ferritin, MCW, and many others. whereas taking rapamycin.

So no, I completely imagine that there’s an optimum dose and/or frequency for taking rapamycin.

This research of cats being handled for hypertrophic cardiomyopathy signifies one of the best dose will not be the best dose.

I feel the anecdotal reporting from discussion board members is starting to provide us a clue that greater doses are usually not essentially extra useful.

This video has be beforehand posted, however I gained’t make you search for it.

“Understanding Feline HCM: Prognosis, Genetic Mutations and Rising Therapy Choices Dr. Joshua Stern – UC Davis”

The factor that pushes me to do a bigger dose every so often are the outcomes from fasting research. Fasting has completely different autophagic results which can be magnified the longer the quick goes on. Since Rapamycin is a fasting mimetic, I imagine that the identical may very well be true for Rapamycin use and perhaps a couple of times a yr, a big dose with an extended washout interval may very well be adopted. Generally selection is required.

As an apart, I feel fasting is additive to Rapamycin’s autophagic results. My father, who does OMAD however not Rapamycin additionally experiences canker sores when he fasts all Ng with related Rapa unwanted side effects.