Hello,
Two issues right here. First, that’s narrowly true of cats however not canines: people share 90% of genes in widespread with cats, however 85% with rodents and 84% with canines. Moreover, home catas have an exceptionally excessive frequency of disease-causing SNPs,
considerably increased than earlier research in different mammals, similar to, cow [38], canine [39], rat [40–42], sheep [43, 44], pig [45], and horse [46]. Even rhesus macaques, with twice as many variants as human, don’t method the identical ranges of cat SNV variation [47, 48].”
A brand new home cat genome meeting based mostly on lengthy sequence reads empowers feline genomic drugs and identifies a novel gene for dwarfism
This pertains to one other misunderstanding you seem to have beneath.
Moreover, no matter different deserves cats and canines might have as experimental fashions, we don’t have any rapa lifespan research in both species (but). Absent that data, the cat and canine information are solely of curiosity for hints of conservation, no matter how closely-related they’re.
The truth that you had extra side-effects on increased doses doesn’t imply that decrease doses are extra or equally efficient. Miserable as it might be to ponder, it might be that the doses required to meaningfully have an effect on human ageing should not achievable with out unacceptable side-effects. Definitely translating the rodent dose-response research raises that concern.
By definition there may be an optimum dose and/or frequency for taking rapamycin. The query is how excessive that dose is and if we’re even within the ballpark.
One thing you could not understand is that hypertrophic cardiomyopathy is just not the type of cardiomyopathy that occurs to some extent in all people because of ageing processes together with blood stress and cardiac amyloid, however is a genetic illness that’s widespread in cats however uncommon in people. It is smart {that a} genetic illness of coronary heart muscle overgrowth might be handled with a drug that suppresses a progress pathway, however that doesn’t essentially inform us a lot about ageing in people until they’re unfortunate sufficient to be genetically inclined to the illness.
Except for side-effects, which can or might not inform us something about efficacy, what would you level to? Additionally do not forget that Joan Mannick says that almost each individual on placebo in her trials was subjectively sure she or he was on an anti-aging drug …
