Make your arguments for Rapamycin dosed As soon as Weekly vs. As soon as Each Two Weeks – longevity

@brandy111 Good level! Sirolimus absorption has been a hassle spot and why compounding variations can have subject vs. commercially accessible.

Dr. Mannick’s pod forged introduced up many good factors together with the remark about mTOR modulation and the way it modifications with ageing – youthful folks flip off mTOR once they quick (assuming she is speaking about once they sleep) and older folks don’t do that modulation as a lot. Taking your mTOR blocker of alternative at night time when it has a peak might make sense?

Making an attempt to imitate the mTOR modulation of the younger is one strategy, however it seems that periodic blocking of mTOR of youthful (mice) might have even a greater impact on longevity. This will likely create a query of making an attempt mimic youthful mTOR modulation vs. Supraphysiologic (extra blocking than is generally seen than simply by being younger).

Observationally, it appears many of the specialists that attempt the each 2 week (excessive) dosing, return to the weekly dosing – Attia, Inexperienced, Dr. B.

After having tried totally different doses from 1 – 6 mg +GFJ (4-6 mg was each two weeks), I feel my candy spot is 3 mg + GFJ weekly. I could attempt a better dose once in a while. Thanks for all of the dialogue and data.

Hey Chris… you will have come to the place I’ve… 2mg and GFJ…I must be getting a 12 mg dose based mostly on my GFJ response. Appears to be working effectively… after months of 36 mg… every little thing appears goid throughout the board… will submit bloid panel in a couple of weeks.