Identical concept with flunarizine. Extrapyramidal reactions are extra frequent within the aged and tardive dyskinesia will be life altering in a foul manner. It’s the principle purpose that a whole class of antipsychotics has been changed by the atypicals.
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It appears like its uncommon, and reversible…
Truthful sufficient – how is the extent of calcium in your weight loss plan (I’m assuming your vitamin D and Ok are at good ranges)?
By the way, though you’re feeling underwhelmed with Rapa, you’ve gotten talked about prior to now that your keratosis (or some type of age spots) hasn’t returned since being on it, so don’t suppose that you’ve wasted money and time for nothing.
I’m wondering if you happen to fingernails have gone again to child age because you had been taking such an unlimited quantity of Rapa (with GFJ) every time 
Now its time for different issues to be catching up!!
Anyway, no matter you do, I hope it has a optimistic impact – you actually are a trailblazer for the remainder of the group right here.
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Love the hacking spirit, however did I miss one thing on the human translation re meclizine dosing.
“728mg a day for an individual at 70 kilo”
How is 25mg/day going to generate a sign?
Though I (n=1) wouldn’t mess with an anticholinergic. Cognitive is my #1 longevity focus.
Most individuals do NOT get sufficient choline from weight loss plan, and relying in your genes, you might be in a HUGE deficit. I’m homozygous C677T, so I’ve been addressing my methylation from begin of interventions as a wanted bio-hack. You possibly can add your 23andme into Chris Masterjohn portal, will generate your choline necessities.
My abstract reveals I ought to be consuming 9 egg yolks/day (1 egg yolk = 164mg choline)…I eat eggs often, however haven’t been consuming 9/day and impossible possible getting the each day choline equal from the meals macros beneath itemizing, so I complement. I eat plenty of nuts and salmon with my keto weight loss plan, however even nonetheless, possible no getting sufficient. I don’t eat any liver.
I take 1200mg/day of L-alphagyclerolphosphorylcholine.
Masterjohn isn’t involved about TMAO, and neither am I primarily based on my analysis. CM: “On a scale of 0 to 10, my concern for minimizing TMAO is at present a 3. My confidence in that is about 10%, so I take into account it extremely possible I may change my thoughts in both course as new analysis is revealed. On the finish of the day, choline that your intestine microbes flip into TMAO is choline you didn’t take up, so, at greatest, it was a waste”
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Apparently, my meclizine experiment goes to be short-lived. Stopped taking rapamycin ~two weeks in the past and began taking meclizine @25 mg/day. My function was to proceed delicate mTORC1 suppression whereas ready to see if my levels of cholesterol improved. My ranges elevated whereas taking rapamycin at greater dosages of 10 – 20 mg. biweekly with grapefruit juice and olive oil.
I’ve taken meclizine prior to now as a sleep help and for dizziness and don’t bear in mind any sleepiness issues. 25 mg. of meclizine after my night meal at ~ 5:30 PM makes me sleep like a child for ~8 hours. After taking it for per week I discover I’m sleepy all day. That is in all probability because of a build-up of meclizine within the blood as its half-life is ~6 hours and doesn’t fully clear earlier than my subsequent dose.
I wish to get my blood markers again to the values earlier than rapamycin. The following time I’ll have blood work accomplished is in about two weeks. After I get the outcomes I’ll determine what to do about rapamycin. If my markers enhance possibly I’ll simply attempt reducing again on the rapamycin dosage.
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Possibly simply take the Meclizine each different day.
Glad you didn’t go straight for the human translated dose 728mg. You’ll have woken up subsequent month.
You have to get one in all these…that’s how the ITP mice stayed awake at their mega doses. Or in actuality, they’ve a very totally different CNS/mind/peripheral metabolism in comparison with people.
The ITP is nice, however wants context and guardrails…translating to people is fraught with large unknowns together with possible fully untranslatable genetic/metabolic pathways. And it’s just about solely a mouse-cancer mannequin. The brains of mice are nothing like human. We’re a much more advanced/complicated species.
Yeah, I’d ditch the mec and reduce on the rapa.
Possibly meclizine ain’t useless but:
‘”Nevertheless distinction with the favorable: Meclizine ameliorates reminiscence deficits in streptozotocin-induced experimental dementia in mice: function of nuclear pregnane X receptors “
“The upshots of our examine proclaim that meclizine protects cognitive deficits by advantage of its antioxidant, anticholinesterase, and antiinflammatory properties.”
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As a aspect notice, Dr. Miller on the ITP was obsessed with two medicine, Meclizine and Astaxanthin, within the interview referenced above. The issue on the time was that they wanted sufficient mice to die to launch a report. The Meclizine report was simply launched. Right here’s hoping the Astaxanthin mice are nonetheless alive and kicking for a very long time. The longer now we have to attend for the report, the more practical Astaxanthin in all probability is? Has anybody heard an replace on this?
P.S. I’ve been taking Astaxanthin each day with no uncomfortable side effects. Right here’s to hope!
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Sure – I believe the “take house message” from all of the meclizine analysis I’ve seen (and posted above) up to now is to be very cautious about adopting Meclizine as an anti-aging drug. The researchers I spoke to at UC Davis stated there have been many points with Meclizine given its poor “binding affinity” (and due to this fact, chance of undesirable uncomfortable side effects), however these are tutorial researchers, not clinicians which have any persistence expertise so they’re speaking very typically.
They hope to search out different medicine which have each a greater binding affinity, and mTORC1 inhibition. Given how lengthy it takes for any such analysis to progress, its possible years away earlier than any outcomes in the direction of that aim from this analysis group, I think.
Given the analysis I’ve seen right here, I’m in no hurry so as to add Meclizine to my routine.
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RapAdmin, Did you ever attempt Meclizine? In that case, what was your expertise and what are your present ideas about utilizing it? For me, as some others have famous, it seems to be just like the impact on BPH signs eliminates it from consideration. I’m additionally unsure about it’s long run psychological results, if any. Might it, like among the older antihistamines be related to Alzheimer’s?
I didn’t. The anti-cholinergic results appeared regarding to me. I’m at present sticking with rapamycin and rapalogues.
