It seems to be like Peter is now taking Doxycycline with Rapamycin now. Has anybody else tried the Doxy? Is it to stop infections or for another profit?
Rapamycin Protocol: 6 mg per week (one time per week, identical time of day; 0.1 mg per kg of weight), plus 100 mg of doxycycline (taken at identical time as Rapamycin). (Experimental IND Protocol)
NOTE: Rapamycin ranges had been constructed up from 2mg to 6mg over a four-week interval. Throughout this era, CBC, CMP, ferritin, ESR, CRP, fibrinogen, homocysteine, fasting insulin, HDL/Trig ratio was measured. As well as, InBody physique composition (lean physique mass and visceral fats now and each three to sixth months); blood stress as soon as per week simply earlier than dosing. Monitoring modifications in Coronary heart Price Variability/Sleep Metrics, as effectively blood sugar and insulin management.
Dietary supplements (Extra):
Alpha Lipoic Acid
Selenomethionine
Lion’s Mane
Spermidine
Vitamin D w/ K2
DHEA
Seed/Probiotic (30 billion micro organism)
CoQ10 w/ PQQ
Quercetin
Xymogen (Methyl Defend)
Magnesium Threonate
Percepta
Prescription Med
(Particular to me):
Armour Thyroid
Vascepa (EPA Fish Oil)
Metformin (1mg – 1.5mg ER)
Hormones & Injectables:
Losartan
Testosterone injection: (40mg) 0.2 cc / 2 occasions per week (Wednesday & Sunday mornings)
Leqvio (Inclisiran): Injectable for Hypercholesteremia – Each three months.
That is his protocol: Dropbox – Peters Longevity Practices Fall 2022.pdf – Simplify your life
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Doxycyclin senolytic?
Doxycycline has been proven to have some senolytic properties, that means it might assist clear senescent cells, that are cells which have stopped dividing and may contribute to getting older and age-related ailments. Some research have urged that doxycycline might help to cut back the variety of senescent cells in mice and should have potential as a remedy for age-related ailments. Nevertheless, extra analysis is required to completely perceive the consequences of doxycycline on senescence and its potential as a senolytic remedy. As with all drug, you will need to talk about the potential advantages and dangers with a healthcare supplier earlier than beginning remedy.
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I personally wouldn’t danger my intestine micro organism, which I feed with hand-crafted Sauerkraut, joghurt, kombucha and fiber. These small passengers are vital…
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I take (Dasatinib 100 mg + Fisetin 2000 mg + Quercetin 1000 mg) each 15 days as a senolytic.
Plus ginger and Spermidine daily.
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Minocycline is my antibiotic of alternative.
Strickland BA, Bakhsheshian J, Emmanuel B, Amar A, Giannotta SL, Russin JJ, Mack W. Neuroprotective impact of minocycline towards acute mind harm in medical apply: A scientific evaluation. J Clin Neurosci. 2021 Apr;86:50-57. doi: 10.1016/j.jocn.2021.01.005. Epub 2021 Jan 27. PMID: 33775346.
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For anybody new to Peter Diamandis:
It appears vert untimely to make use of it, (for me), however It has some historical past in longevity analysis:
Supply:
https://genomics.senescence.data/medication/drug_details.php?compound_name=Doxycycline
and
Doxycycline (40 ) is a broad-spectrum antibiotic of tetracycline kind, which might delay the life span of nematodes and Drosophila melanogaster [182,183,184].
https://www.nature.com/articles/s42255-020-00334-y
@Krister_Kauppi Peter Diamandis is somebody you most likely need to add to your longevity specialists taking rapamycin.
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Sure, I examine utilizing Doxycycline weekly from Blogsklonny. I take it with my GP’s prescription and suppervision. I take one 100mg of Doxy per week. Identical weekly dose of Peter. For cleansing physique of rogue micro organism and parasites… most cancers prevention. Heck extends lifetime of flies and worms.
Been on it since April 2022. With rapamycin modulation of the immune system… good to have readily available. Use further when wanted …I’ve used for a number of days with clogged eye duct glands when my dose of rapamycin was larger.
Peter additionally does TRT… twice per week. Attention-grabbing.
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Attention-grabbing…
Doxocycline
Doxocycline, broad-spectrum antibiotics of the tetracycline class, extends life span in C elegans [220] and Drosophila [221, 222]. Doxycycline suppresses tumor development and metastasis in mice [223, 224]. Importantly, doxycycline is a part of an anti-metastatic mixture, which incorporates doxycyclin, aspirin, lisin and mifepristone [225].
Supply:
From rapalogs to anti-aging system, Mikhail V. Blagosklonny
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482593/
nonetheless…
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Gregory M Solis, Rozina Kardakaris, Elizabeth R Valentine, Liron Bar-Peled, Alice L Chen, Megan M Blewett, Mark A McCormick, James R Williamson, Brian Kennedy, Benjamin F Cravatt, Michael Petrascheck (2018) Translation attenuation by minocycline enhances longevity and proteostasis in previous post-stress-responsive organisms eLife 7:e40314
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I’ve been on doxy for the final 1.5 years to assist with pimples. I take 100mg every day with meals. In my expertise, it’s been very efficient. I’m curious to dive into the potential longevity advantages and see which mechanisms it acts on.
Phrase of warning: if you happen to take doxy on an empty abdomen or instantly earlier than mendacity down, you’ll most likely get great nausea. I can’t overstate how unhealthy it feels (!) – you’ll be able to’t give attention to anything for hours. After I take it with a meal or gentle snack, I’ve by no means had an issue.
Thrilling to see that Diamandis is on rapa. Find out how to Construct a Spaceship is an exceptional ebook outlining his quest to construct the X-Prize. He’s a visionary who is aware of the way to execute. He’d be an enormous asset for the longevity neighborhood.
