Your mindset seems to be that decrease LDL is at all times higher in all contexts. However the epi research reveals that won’t at all times be true. Definitely, as you say, correlational work of that kind has its limits.
(Though the “sick affected person” bias shouldn’t be a serious confounder – that occurs extra in case you are measuring LDL when folks arrive on the hospital; these measurements are years earlier than loss of life normally. However however, we will’t say for positive – agreed.)
However can’t say for positive is true in each instructions – we will’t say that decrease LDL is useful in all contexts. We lack information.
You say that you just aren’t saying that “everybody must be on a statin.” However after I learn every part you write – apart from that sentence – it looks as if your logic dictates that they need to be. Most likely that is simply because of my misunderstanding. However I suppose it could make clear your place if you happen to talked about just a few examples the place you don’t consider an individual must be on a statin.
These ranges look nice. Sadly ApoB doesn’t get lumped in with a regular ldl cholesterol check you need to order it individually
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Thanks. That’s what I wished to know. I hoped I might coax the info on ApoB out of the usual ldl cholesterol information, however I suppose not. 
Easy – I’m not saying everybody must be on a statin as a result of there are a number of methods of reducing LDL/apoB aside from statins. Statins have potential negative effects, so as with all intervention there must be a price/threat/profit evaluation.
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It’s simple to order ApoB if you happen to simply ask subsequent time you get a lipid panel order out of your healthcare supplier. Most likely even higher could be direct measure of LDL particles through NMR Lipoprofile, though it’s costlier too.
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FWIW
NMR LipoProfile® With Lipids and Insulin Resistance Markers
(With Graph)
For LabCorp Take a look at:123638
Within the US $125.00 is quantity billed to insurance coverage within the NYC space.(as of 03/04/2023, spoke to LabCorp CS to get estimate check price)
Evaluate the price, confirm the check code as LabCorp has identical check identify with totally different choices/parameters/measurements.
Evaluation PDF beneath for testing parameters
NMR LipoProfile Assay Choices Desk.pdf (40.5 KB)
One check price $63.00{was on 03/05/2023 on web page] selfpay via Marek, I didn’t confirm which one.
Store round for the price, as there are various locations providing direct self testing companies.
Evaluation
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I need to argue about issues have been there isn’t nice experience. Nevertheless it’s true this can be a “do your personal analysis” web site. I hope nobody does main adjustments with out consulting with their physician.
We’ve already debated that LDL “paradox”, which btw is identical for being chubby, the place it’s related to decrease all trigger mortality.
Larger lipids and being chubby (quite than regular weight) is related to decrease all trigger mortality.
Within the quick time period, just a few years, we do have the info. There’s a meta evaluation of randomized managed trials of statins on this thread that do present a lower in all trigger mortality relying on lower of LDL. Even in folks with out preexisting coronary heart illness.
Who is aware of the long run results on ACM? Or long run results of something on ACM? Until your affiliation research is controlling for parasitic infections, liver illness, absorption points, you might be removed from figuring out positive. And even then there is likely to be one thing you’re not controlling for.
In your research, those that took statins (lipid reducing medicines) the affiliation with all trigger mortality was weaker. Which makes the authors conclude that it isn’t a causal relationship and I quote
“Therefore it could be incorrect to make use of our information as an argument towards the usage of lipid reducing therapy within the prevention of atherosclerotic heart problems and mortality.”
