I’m wondering if rapamycin might need its results on muscle growing old by way of ceramide inhibition? Anybody extra acquainted on this matter, and whether or not there are any pure ceramide inhibitors?
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I take 6mg Rapa with Evoo, 500mg Metformin and 50mg Acarbose Monday morning and wait till Wednesday morning earlier than I do my first of three WL weekly classes. Monday and Tuesdays I attempt to maintain my protein consumption low and keep away from insulin spikes in an effort to maximize mTOR inhibition. Pre Rapa, each morning, I used to do a 20min 180 levels Fahrenheit sauna session adopted by chilly plunge.
Evidently Sauna will increase autophagy however on the identical time will increase mTOR and protein synthesis, however on the optimistic facet chilly water reduces mTOR exercise.
As my morning sauna + chilly plunge session has such a optimistic influence on the remainder of my day, I’d very a lot recognize any insights or recommendation 
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I’ve placed on muscle whereas on 4mg of rapamycin for 3 months. It’s very posible that I might have put extra had I not been on it, however the level stays : its doable to placed on muscle mass whereas on rapamycin. See
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My lean physique mass has elevated by 3% simply from studying Agetron posts. I admit that my rapamycin use is a confounding consider my N equals one.
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I’m curious and look out for rapamycin and ceramide interactions too. However in the mean time, that is out, on utilizing myriocin for ceramide inhibition on aged mice: https://scitechdaily.com/researchers-identify-a-new-hallmark-of-aging/
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Zazim : My lean physique mass has elevated by 3% simply from studying Agetron posts.
Hahaha… what helped??? Curious.
Was within the fitness center as we speak with a Marine buddy… beast of a man… 240 kilos 6ft. 4 in.
I advised him his mass is enviable.
His reply was … commerce it in your shredded look.
So there it’s.
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